volume 93, issue 0, P2-P-204 2020
DOI: 10.1254/jpssuppl.93.0_2-p-204
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Abstract: Unilateral ureteral obstruction (UUO) is a well-established model for the study of interstitial fibrosis in the kidney. In this study, we investigated effects of two antioxidants, N-acetyl cysteine (NAC) and tempol, on UUO-induced renal interstitial fibrosis in mice. Fibrotic area of Masson trichrome-stained section significantly increased by UUO. This change was inhibited by the treatment of NAC, but not by tempol. Tempol administration increased the amount of hydrogen peroxide in the kidney. Catalase activit…

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