Different Patterns of Cerebral Injury in Dementia With or Without Diabetes

Vascular risk factors and longitudinal changes on brain MRI

“…Even if the risk factors could have other mechanisms, an ischemic one is not trivial. Our findings are consistent with neuropathologic studies of diabetic [23][24][25] and hypertensive 3,26 subjects that have shown that these 2 risk factors are both associated with infarcts.…”

Vascular risk factors and longitudinal changes on brain MRI

“…Even if the risk factors could have other mechanisms, an ischemic one is not trivial. Our findings are consistent with neuropathologic studies of diabetic [23][24][25] and hypertensive 3,26 subjects that have shown that these 2 risk factors are both associated with infarcts.…”

Diabetes is Not Associated with Alzheimer’s Disease Neuropathology

“…In this first large autopsy study from a LMIC, no association between diabetes and AD neuropathology was found. Our results are in agreement with several neuropathological studies reported in HIC [18 –29]. One of the first retrospective autopsy studies on the association between diabetes and AD neuropathology was the investigation performed by Heitner and Dickson [18], which found no differences for senile plaque score or Braak stages in the entorhinal cortex and hippocampus in persons with diabetes compared to those without the disease.…”

Transactive DNA Binding Protein 43 Rather Than Other Misfolded Proteins in the Brain is Associated with Islet Amyloid Polypeptide in Pancreas in Aged Subjects with Diabetes Mellitus

“…Here, based on our results, assessing the hallmark lesions of AD and other dementias and the alteration related to DM, i.e., IAPP/IR, no association could be seen between DM and AD. The lack of a link between AD and DM is also supported by the observations that less AD related pathology has been reported to be seen in subjects with DM when compared to non-diabetic subjects [21, 50]. Our results are in line with the above, as our demented subjects with DM displayed less misfolded proteins (not significant) in their brain when compared with non-diabetics.…”

Vascular risk factors and longitudinal changes on brain MRI

“…Even if the risk factors could have other mechanisms, an ischemic one is not trivial. Our findings are consistent with neuropathologic studies of diabetic [23][24][25] and hypertensive 3,26 subjects that have shown that these 2 risk factors are both associated with infarcts.…”

Diabetes is Not Associated with Alzheimer’s Disease Neuropathology

“…In this first large autopsy study from a LMIC, no association between diabetes and AD neuropathology was found. Our results are in agreement with several neuropathological studies reported in HIC [18 –29]. One of the first retrospective autopsy studies on the association between diabetes and AD neuropathology was the investigation performed by Heitner and Dickson [18], which found no differences for senile plaque score or Braak stages in the entorhinal cortex and hippocampus in persons with diabetes compared to those without the disease.…”

Transactive DNA Binding Protein 43 Rather Than Other Misfolded Proteins in the Brain is Associated with Islet Amyloid Polypeptide in Pancreas in Aged Subjects with Diabetes Mellitus

“…Here, based on our results, assessing the hallmark lesions of AD and other dementias and the alteration related to DM, i.e., IAPP/IR, no association could be seen between DM and AD. The lack of a link between AD and DM is also supported by the observations that less AD related pathology has been reported to be seen in subjects with DM when compared to non-diabetic subjects [21, 50]. Our results are in line with the above, as our demented subjects with DM displayed less misfolded proteins (not significant) in their brain when compared with non-diabetics.…”

Vascular risk factors and longitudinal changes on brain MRI

“…Even if the risk factors could have other mechanisms, an ischemic one is not trivial. Our findings are consistent with neuropathologic studies of diabetic [23][24][25] and hypertensive 3,26 subjects that have shown that these 2 risk factors are both associated with infarcts.…”

Diabetes is Not Associated with Alzheimer’s Disease Neuropathology

“…In this first large autopsy study from a LMIC, no association between diabetes and AD neuropathology was found. Our results are in agreement with several neuropathological studies reported in HIC [18 –29]. One of the first retrospective autopsy studies on the association between diabetes and AD neuropathology was the investigation performed by Heitner and Dickson [18], which found no differences for senile plaque score or Braak stages in the entorhinal cortex and hippocampus in persons with diabetes compared to those without the disease.…”

Transactive DNA Binding Protein 43 Rather Than Other Misfolded Proteins in the Brain is Associated with Islet Amyloid Polypeptide in Pancreas in Aged Subjects with Diabetes Mellitus

“…Here, based on our results, assessing the hallmark lesions of AD and other dementias and the alteration related to DM, i.e., IAPP/IR, no association could be seen between DM and AD. The lack of a link between AD and DM is also supported by the observations that less AD related pathology has been reported to be seen in subjects with DM when compared to non-diabetic subjects [21, 50]. Our results are in line with the above, as our demented subjects with DM displayed less misfolded proteins (not significant) in their brain when compared with non-diabetics.…”