Different Inhibition Mechanisms of Dipeptidyl Peptidase IV by Tryptophan Containing Peptides and Amides

Stöckel-Maschek, Angela; Stiebitz, B.; Faust, Jürgen; Born, Ilona; Kähne, Thilo; Gorrell, Mark D.; Neubert, Klaus

doi:10.1007/0-306-47920-6_8

Cited by 9 publications

(5 citation statements)

References 2 publications

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“…DPP‐IV binding sites outside the active site have been reported following molecular docking studies (Lorey et al, ; Nongonierma, Mooney, Shields, & FitzGerald, ). Molecules which bind outside the active site of DPP‐IV act through noncompetitive, mixed type, or uncompetitive modes of inhibition (Domenger et al, ; Lacroix & Li‐Chan, ; Lan, Ito, Ito, & Kawarasaki, ; Lorey et al, ; Nongonierma & FitzGerald, ; Stöckel‐Maschek et al, ).…”

Section: Structure Substrate Specificity and Mode Of Inhibition Of mentioning

confidence: 99%

Features of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from dietary proteins

2017

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Dipeptidyl peptidase IV (DPP-IV) is involved in incretin hormone processing and therefore plays a key role in glycemic regulation. This review summarizes the latest developments in food proteinderived DPP-IV inhibitory peptides. The in silico approaches currently used to develop targeted strategies for the enzymatic release of DPP-IV inhibitory peptides from food proteins are outlined.The features within the primary sequences of potent DPP-IV inhibitory di-, tri-, and larger peptides, having half maximal inhibitory activity (IC 50 ) < 100 mM, were evaluated and the outcomes are presented herein. It is proposed that detailed analysis of those food derived peptides identified in humans following ingestion may constitute a practical strategy for the targeted identification of novel bioavailable DPP-IV inhibitory peptides. Human intervention studies are required as the specific role of food protein-derived DPP-IV inhibitory peptides in the regulation of glycaemia in humans remains to be fully elucidated.

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Section: Structure Substrate Specificity and Mode Of Inhibition Of mentioning

confidence: 99%

Features of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from dietary proteins

2017

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“…Although it is not well evidenced for the inhibition mechanism of DPPIV by seaweed derived peptides, many are reported that the analogue has been designed based on the knowledge of the enzyme's substrate specificity. Many are dipeptide derivatives, and are small, low molecular weight compounds with good oral availability, and they function as competitive inhibitors of the enzyme (Stöckel‐Maschek and others ; Deacon and Holst ).…”

Section: Bioactivities Of Seaweed Protein‐derived Peptidesmentioning

confidence: 99%

Bioactive Peptides Derived from Seaweed Protein and Their Health Benefits: Antihypertensive, Antioxidant, and Antidiabetic Properties

Admassu

Gasmalla

Yang

et al. 2017

Journal of Food Science

195

113

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Cardiovascular diseases and diabetes are the biggest causes of death globally. Therefore, prevention of these diseases is a focus of pharmaceuticals and functional food manufacturers. This review summarizes recent research trends and scientific knowledge in seaweed protein-derived peptides with particular emphasis on production, isolation and potential health impacts in prevention of hypertension, diabetes and oxidative stress. The current status and future prospects of bioactive peptides are also discussed. Bioactive peptides have strong potential for use in therapeutic drug and functional food formulation in health management strategy, especially cardiovascular disease and diabetes. Seaweeds can be used as sustainable protein sources in the production of these peptide-based drugs and functional foods for preventing such diseases. Many studies have reported that peptides showing angiotensin converting enzyme inhibition, antihypertensive, antioxidative and antidiabetics activities, have been successfully isolated from seaweed. However, further research is needed in large-scale production of these peptides, efficient isolation methods, interactions with functional foods and other pharmaceuticals, and their ease to digestion in in vivo studies and safety to validate the health benefits of these peptides.

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“…Porcine and recombinant human DPP-IV are the most common species that have been used to assess the inhibitory activity of molecules. Although the enzyme sequence is highly conserved among mammalian species, the porcine and human DPP-IV enzymes are not identical and different inhibition patterns between the two species have been reported (Lacroix & Li-Chan, 2015;Stöckel-Maschek et al, 2003).…”

Section: Structural Characteristics and Mode Of Action Of Dpp-iv Inhibitory Peptidesmentioning

confidence: 99%

Food-derived dipeptidyl-peptidase IV inhibitors as a potential approach for glycemic regulation – Current knowledge and future research considerations

Lacroix

Li‐Chan

2016

Trends in Food Science & Technology

138

104

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Background: Diabetes, which currently affects 1 in 11 adults, is considered one of the biggest worldwide health crises of the 21 st century. Over the last decade, synthetic inhibitors of the enzyme dipeptidyl-peptidase IV (DPP-IV) have emerged as an effective pharmaceutical approach for the management of type 2 diabetes. These molecules exert their beneficial effect by preventing the inactivation of gut-derived hormones that play a pivotal role in glycemic regulation. More recently, food components have been suggested as sources of DPP-IV inhibitors with the potential to help manage blood glucose levels.Scope and approach: This review examines the sources, production, molecular characteristics and modes of action of food-derived DPP-IV inhibitors. Insights into the needs for future research to validate their efficacy and to establish their application in the management of type 2 diabetes are also discussed. Key findings and conclusions:To date, hydrolysates of protein from a variety of food commodities, including both plant and animal sources, have been shown to be able to inhibit the activity of the DPP-IV enzyme. Moreover, a number of peptides, either isolated from these hydrolysates or synthetically produced, as well as non-protein-derived compounds such as polyphenols, have also been identified as DPP-IV inhibitors. These food-derived constituents present different degrees of potency and modes of action on the DPP-IV enzyme. While their effectiveness in humans is currently unknown, findings from in vitro and animal studies conducted to date warrant further research to evaluate their potential as functional food ingredients for glycemic regulation.

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Different Inhibition Mechanisms of Dipeptidyl Peptidase IV by Tryptophan Containing Peptides and Amides

Cited by 9 publications

References 2 publications

Features of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from dietary proteins

Features of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from dietary proteins

Bioactive Peptides Derived from Seaweed Protein and Their Health Benefits: Antihypertensive, Antioxidant, and Antidiabetic Properties

Food-derived dipeptidyl-peptidase IV inhibitors as a potential approach for glycemic regulation – Current knowledge and future research considerations

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