Different antibiotic treatments for group A streptococcal pharyngitis

Abstract

Evidence is insufficient for clinically meaningful differences between antibiotics for GABHS tonsillopharyngitis. Limited evidence in adults suggests cephalosporins are more effective than penicillin for relapse, but the NNTB is high. Limited evidence in children suggests carbacephem is more effective for symptom resolution. Data on complications are too scarce to draw conclusions. Based on these results and considering the low cost and absence of resistance, penicillin can still be recommended as first choice.

A review of the reporting of web searching to identify studies for Cochrane systematic reviews

“…Google and Google Scholar were the only search engines reported. Both search engines were reported in 7 reviews; Google was reported as the sole search engine in 4 reviews (11 reviews in total); Google Scholar was reported as the sole search engine in 12 reviews (19 reviews in total); and an unnamed search engine was reported in 1 review …”

“…Of the reviews which reported search terms, these were typically reported in appendices. Van Driel et al and Posadzki et al reported that Google was searched in the results section but in neither review was Google mentioned in the methods section or appendices.…”

A review of the reporting of web searching to identify studies for Cochrane systematic reviews

“…Google and Google Scholar were the only search engines reported. Both search engines were reported in 7 reviews; Google was reported as the sole search engine in 4 reviews (11 reviews in total); Google Scholar was reported as the sole search engine in 12 reviews (19 reviews in total); and an unnamed search engine was reported in 1 review …”

“…Of the reviews which reported search terms, these were typically reported in appendices. Van Driel et al and Posadzki et al reported that Google was searched in the results section but in neither review was Google mentioned in the methods section or appendices.…”

Controversies in the management of acute tonsillitis: an evidence‐based review

“…The highest levels of evidence within this category comes from a Cochrane review (level 1 evidence) conducted in 2013 examining the role of antibiotics in the presence of GABHS . The review included seventeen trials in its analysis (5352 total participants); 16 compared penicillin with other antibiotic agents (six with cephalosporins, six with macrolides, three with carbacephem and one with sulphonamides), with the final one comparing clindamycin with ampicillin.…”

Less haste, more speed: Does delayed blood culture transport time lead to adverse incubation times or yield?

“…Most empirical guideline would seek to treat invasive S. pyogenes in a septic patient with gram positive antibiotics, and it remains reliably susceptible to penicillin. 11 In patients who are difficult to obtain cultures from, such as paediatric or the immunocompromised, these results may be of increased importance, to prevent the pursuit of alternative causes for their clinical presentation; and, for the sake of stewardship, knowing the organism would allow for narrow-spectrum antimicrobials. The loss of invasive S. pyogenes isolates is of grave concern for the wider community, as missing the rates of circulating pathogenic strains could contribute to hidden pandemics.…”

A review of the reporting of web searching to identify studies for Cochrane systematic reviews

“…Google and Google Scholar were the only search engines reported. Both search engines were reported in 7 reviews; Google was reported as the sole search engine in 4 reviews (11 reviews in total); Google Scholar was reported as the sole search engine in 12 reviews (19 reviews in total); and an unnamed search engine was reported in 1 review …”

“…Of the reviews which reported search terms, these were typically reported in appendices. Van Driel et al and Posadzki et al reported that Google was searched in the results section but in neither review was Google mentioned in the methods section or appendices.…”

Controversies in the management of acute tonsillitis: an evidence‐based review

“…The highest levels of evidence within this category comes from a Cochrane review (level 1 evidence) conducted in 2013 examining the role of antibiotics in the presence of GABHS . The review included seventeen trials in its analysis (5352 total participants); 16 compared penicillin with other antibiotic agents (six with cephalosporins, six with macrolides, three with carbacephem and one with sulphonamides), with the final one comparing clindamycin with ampicillin.…”

Less haste, more speed: Does delayed blood culture transport time lead to adverse incubation times or yield?

“…Most empirical guideline would seek to treat invasive S. pyogenes in a septic patient with gram positive antibiotics, and it remains reliably susceptible to penicillin. 11 In patients who are difficult to obtain cultures from, such as paediatric or the immunocompromised, these results may be of increased importance, to prevent the pursuit of alternative causes for their clinical presentation; and, for the sake of stewardship, knowing the organism would allow for narrow-spectrum antimicrobials. The loss of invasive S. pyogenes isolates is of grave concern for the wider community, as missing the rates of circulating pathogenic strains could contribute to hidden pandemics.…”

A review of the reporting of web searching to identify studies for Cochrane systematic reviews

“…Google and Google Scholar were the only search engines reported. Both search engines were reported in 7 reviews; Google was reported as the sole search engine in 4 reviews (11 reviews in total); Google Scholar was reported as the sole search engine in 12 reviews (19 reviews in total); and an unnamed search engine was reported in 1 review …”

“…Of the reviews which reported search terms, these were typically reported in appendices. Van Driel et al and Posadzki et al reported that Google was searched in the results section but in neither review was Google mentioned in the methods section or appendices.…”

Controversies in the management of acute tonsillitis: an evidence‐based review

“…The highest levels of evidence within this category comes from a Cochrane review (level 1 evidence) conducted in 2013 examining the role of antibiotics in the presence of GABHS . The review included seventeen trials in its analysis (5352 total participants); 16 compared penicillin with other antibiotic agents (six with cephalosporins, six with macrolides, three with carbacephem and one with sulphonamides), with the final one comparing clindamycin with ampicillin.…”

Less haste, more speed: Does delayed blood culture transport time lead to adverse incubation times or yield?

“…Most empirical guideline would seek to treat invasive S. pyogenes in a septic patient with gram positive antibiotics, and it remains reliably susceptible to penicillin. 11 In patients who are difficult to obtain cultures from, such as paediatric or the immunocompromised, these results may be of increased importance, to prevent the pursuit of alternative causes for their clinical presentation; and, for the sake of stewardship, knowing the organism would allow for narrow-spectrum antimicrobials. The loss of invasive S. pyogenes isolates is of grave concern for the wider community, as missing the rates of circulating pathogenic strains could contribute to hidden pandemics.…”