Different activation dynamics in multiple neural systems during simulated driving

Calhoun, Vincent; Pekar, James J.; McGinty, Vince; Watson, Todd D.; Pearlson, Godfrey D.

doi:10.1002/hbm.10066

Cited by 66 publications

(130 citation statements)

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“…Signal in the anterior cingulate cortex, an area often associated with error monitoring and inhibition, decreased exponentially with a rate proportional to driving speed, while decreases in frontoparietal (FP) regions, implicated in vigilance, correlated with speed. Increases in cerebellar and occipital areas, presumably related to complex visuomotor integration, were activated during driving but not associated with driving speed (Calhoun et al, 2002).…”

Section: Introductionmentioning

confidence: 80%

“…Methods are those described previously in Calhoun et al (2002). We obtained fMRI scans of subjects as they twice performed a 10-min task consisting of 1-min epochs of: (a) an asterisk fixation task, (b) active simulated driving, and (c) watching a simulated driving scene (while randomly moving fingers over the controller).…”

Section: Experimental Designmentioning

confidence: 99%

“…We were interested in an examination of the intoxicationinduced changes in the temporal dynamics of drivingrelated networks (see Calhoun et al, 2002). To do this, we first perform an ICA analysis on the 9 Â 2 sober-condition data sets to generate a set of maximally independent images.…”

Section: Fmri Analysis Overviewmentioning

confidence: 99%

“…In a previous study, we applied blood oxygen leveldependent functional magnetic resonance imaging (BOLD fMRI) (Ogawa et al, 1990) to simulated driving, using a driving skill game that presents the participant with an 'incar' view of a road and a readout of speed (Calhoun et al, 2002). We analyzed the resulting BOLD data using independent component analysis (ICA), to explore the dynamics of brain networks subserving 'driving.'…”

Section: Introductionmentioning

confidence: 99%

“…In our previous study, ICA extracted six driving-related networks from time-dependent BOLD fMRI data acquired during simulated driving (Calhoun et al, 2002). This analysis revealed sets of brain regions that were differentially activated by simulated driving.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Alcohol Intoxication Effects on Simulated Driving: Exploring Alcohol-Dose Effects on Brain Activation Using Functional MRI

Calhoun

Pekar

Pearlson

2004

Neuropsychopharmacol

172

143

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Driving while intoxicated is a major public health problem. We investigated impaired driving using a simulated driving skill game that presents an 'in-car' view of a road and a readout of speed. We explored brain activation and behavioral alterations from baseline at two blood alcohol concentrations (BACs). Participants received single-blind individualized doses of beverage alcohol designed to produce blood alcohol content (BAC) of 0.04 and 0.08 or placebo. Scanning occurred on a 1.5 Tesla Philips MRI scanner after training to asymptote performance. Analysis was performed using independent component analysis (ICA) to isolate systematically nonoverlapping 'networks' and their time courses. Imaging results revealed seven separate driving-related brain networks with different time courses. Several significant findings were observed for the imaging data. First, dose-dependent functional magnetic resonance imaging (fMRI) changes were revealed in orbitofrontal (OF) and motor (but not cerebellar) regions; visual and medial frontal regions were unaffected. Second, cerebellar regions were significantly associated with driving behavior in a dose-dependent manner. Finally, a global disruptive effect of alcohol on the ICA time courses was observed with highly significant differences in OF and motor regions. Alcohol thus demonstrated some behavioral effects and unique, disruptive, dose-dependent effects on fMRI signal within several brain circuits. The fMRI data also suggest that the deficits observed in alcohol intoxication may be modulated primarily through OF/anterior cingulate, motor and cerebellar regions as opposed to attentional areas in frontoparietal cortex.

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Section: Introductionmentioning

confidence: 80%

Section: Experimental Designmentioning

confidence: 99%

Section: Fmri Analysis Overviewmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Alcohol Intoxication Effects on Simulated Driving: Exploring Alcohol-Dose Effects on Brain Activation Using Functional MRI

Calhoun

Pekar

Pearlson

2004

Neuropsychopharmacol

172

143

View full text Add to dashboard Cite

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Chronic pulmonary thromboembolism in a patient with a fontan circulation: Percutaneous management

Dehghani

Collins

Horlick

et al. 2007

Cathet Cardio Intervent

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Chronic pulmonary embolism is a common complication in patients with Fontan circulations. When anticoagulation is ineffective and surgery is contraindicated, percutaneous techniques may be considered. The authors report the first case of successful catheter intervention in a 30-year-old woman with a Fontan circulation who presented with NYHA class IV symptoms and chronic and complete obstruction of her left pulmonary artery.

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Gemcitabine and docetaxel as front‐line chemotherapy in patients with carcinoma of an unknown primary site

Pouessel

Culine

Becht

et al. 2004

Cancer

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BACKGROUNDThe current study was performed to evaluate the efficacy and toxicity of a noncisplatin‐based chemotherapy regimen combining gemcitabine and docetaxel as front‐line chemotherapy for patients with carcinoma of an unknown primary site.METHODSPatients were to receive intravenous gemcitabine at a dose of 1000 mg/m2 over 30 minutes on Days 1 and 8 and docetaxel at a dose of 75 mg/m2 over 1 hour on Day 8 in an outpatient setting. The schedule was repeated every 3 weeks for a maximum of 6 cycles.RESULTSThirty‐five patients were assessable for response and survival. One complete and 13 partial responses were observed. The overall response rate was 40% (95% confidence interval, 28–52%). The median time to disease progression was 2 months (range, 1–4 months). The median overall survival time was 10 months (range, 0–32 months). Toxicity was reported to be manageable.CONCLUSIONSThe combination of gemcitabine and docetaxel was found to be active in patients with carcinomas of an unknown primary site. However, the overall outcome of these patients remains poor and novel treatment approaches are required. Cancer 2004. © 2004 American Cancer Society.

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Different activation dynamics in multiple neural systems during simulated driving

Cited by 66 publications

References 0 publications

Alcohol Intoxication Effects on Simulated Driving: Exploring Alcohol-Dose Effects on Brain Activation Using Functional MRI

Alcohol Intoxication Effects on Simulated Driving: Exploring Alcohol-Dose Effects on Brain Activation Using Functional MRI

Chronic pulmonary thromboembolism in a patient with a fontan circulation: Percutaneous management

Gemcitabine and docetaxel as front‐line chemotherapy in patients with carcinoma of an unknown primary site

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