Differences in the susceptibility to cadmium-induced renal tubular damage and osteoporosis according to sex

Kim, Yong‐Dae; Yim, Dong‐Hyuk; Eom, Sang‐Yong; Moon, Sun-In; Park, Choong-Hee; Kim, Guen-Bae; Yu, Seung-Do; Choi, Byung-Sun; Park, Jung-Duck; Kim, Heon

doi:10.1016/j.etap.2014.06.002

Cited by 22 publications

(28 citation statements)

References 25 publications

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“…Chronic Cd exposure can give rise to renal tubular dysfunction and bone damage (18,19). We measured urinary NAG conhttp://dx.doi.org/10.3346/jkms.2016.31.4.489 centration as a marker of renal tubular dysfunction and BMD for bone damage.…”

Section: Discussionmentioning

confidence: 99%

Environmental exposure to arsenic, lead, and cadmium in people living near Janghang copper smelter in Korea

Kim¹,

Kim²,

Eom³

et al. 2016

ISEE Conference Abstracts

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Concentrations of heavy metals exceed safety thresholds in the soil near Janghang Copper Refinery, a smelter in Korea that operated from 1936 to 1989. This study was conducted to evaluate the level of exposure to toxic metals and the potential effect on health in people living near the smelter. The study included 572 adults living within 4 km of the smelter and compared them with 413 controls group of people living similar lifestyles in a rural area approximately 15 km from the smelter. Urinary arsenic (As) level did not decrease according to the distance from the smelter, regardless of gender and working history in smelters and mines. However, in subjects who had no occupational exposure to toxic metals, blood lead (Pb) and cadmium (Cd) and urinary Cd decreased according to the distance from the smelter, both in men and women. Additionally, the distance from the smelter was a determinant factor for a decrease of As, Pb, and Cd in multiple regression models, respectively. On the other hands, urinary Cd was a risk factor for renal tubular dysfunction in populations living near the smelter. These results suggest that Janghang copper smelter was a main contamination source of As, Pb, and Cd, and populations living near the smelter suffered some adverse health effects as a consequence. The local population should be advised to make efforts to reduce exposure to environmental contaminants, in order to minimize potential health effects, and to pay close attention to any health problems possibly related to toxic metal exposure.

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Section: Discussionmentioning

confidence: 99%

Environmental exposure to arsenic, lead, and cadmium in people living near Janghang copper smelter in Korea

Kim¹,

Kim²,

Eom³

et al. 2016

ISEE Conference Abstracts

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“…After storing it at 37°C for 15 min, stopping solution (2 mL) was added to and mixed with it. By using a spectrophotometer, its fluorescence intensities were measured with a wavelength of 580 nm ( 13 , 14 ). Urinary β 2 -MG was measured by using Enzygnost β 2 -MG Micro Kit (Behring Institute, Mannheim, Germany).…”

Section: Methodsmentioning

confidence: 99%

“…Monoclonal anti-β 2 -MG antibody and anti-2-MG-horseradish peroxidase conjugate solution were used. After that, color intensities were measured with a wavelength of 450 nm by using a spectrophotometer ( 13 , 14 ).…”

Section: Methodsmentioning

confidence: 99%

Associations of Low Environmental Exposure to Multiple Metals with Renal Tubular Impairment in Korean Adults

Lim

Choi

et al. 2016

ToxicolRes

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Recently several studies reported that the renal toxicity of lead (Pb) and cadmium (Cd) may exist in even a low level exposure. In terms of the deterioration of tubular function, it affects the loss of divalent metals and leads to other complications, so renal tubular effect of heavy metals should be well managed. Considering the exposure to heavy metals in reality, it is hard to find the case that human is exposed to only one heavy metal. We designed a cross-sectional study using Korean Research Project on the Integrated Exposure Assessment (KRIEFS) data to investigate the renal effects of multiple metal exposure in general population. We used blood Pb and urinary Cd as exposure measures, and urinary N-acetyl-β-D-glucosaminidase (NAG) and β2-microglobulin (β2-MG) as renal tubular impairment outcome. We conducted linear regression to identify the association between each heavy metal and urinary NAG and β2-MG. And then, we conducted linear regression including the interaction term. Of 1953 adults in KRIEFS (2010~2011), the geometric mean of blood Pb and urinary Cd concentration was 2.21 μg/dL (geometric SD = 1.49 μg/dL) and 1.08 μg/g cr (geometric SD = 1.98 μg/g cr), respectively. In urinary Cd, the strength of the association was also high after adjusting (urinary NAG: β = 0.44, p < 0.001; urinary β2-MG: β = 0.13, p = 0.002). Finally, we identified the positive interactions for the two renal biomarkers. The interaction effect of the two heavy metals of β2-MG was greater than that of NAG. It is very important in public health perspective if the low level exposure to multiple heavy metals has an interaction effect on kidney. More epidemiological studies for the interaction and toxicological studies on the mechanism are needed.

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“…The selection of study participants was described in detail in previous studies (Kim et al 2014(Kim et al , 2016. In brief, the study included 985 adults aged ≥ 30 years who had been living within 15 km of the closed refinery.…”

Section: Study Participantsmentioning

confidence: 99%

Copper–zinc imbalance induces kidney tubule damage and oxidative stress in a population exposed to chronic environmental cadmium

Eom

Yim

Huang

et al. 2019

Int Arch Occup Environ Health

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Purpose This cross-sectional study aimed to assess the effect of environmental cadmium (Cd) exposure and essential metal imbalance on renal tubular damage and oxidative stress in 979 adults living in a Cd-polluted area near an abandoned copper (Cu) refinery. Methods We analyzed urinary Cd concentrations, renal tubular damage and oxidative stress markers, such as beta-2 microglobulin (β2-MG) and N-acetyl-β-d-glucosaminidase (NAG) activity and urine malondialdehyde (MDA) levels. The serum copper-to-zinc ratio (CZR) was used as an essential metal imbalance indicator. We divided the subjects into two Cd exposure groups based on the reference level of urinary Cd for renal dysfunction (2 μg/g creatinine). Results The geometric mean concentration of urinary Cd in all subjects was 2.25 μg/g creatinine. In both low and high Cd exposure groups, urinary Cd levels were positively correlated with urinary NAG activity, but not with serum CZR. After multivariate adjustment, serum CZR was strongly associated with urinary β2-MG levels in the low Cd exposure group (β = 1.360, P = 0.019) and was significantly associated with urinary MDA levels, regardless of Cd exposure level. In addition, the risk of renal tubular damage was significantly associated with urinary Cd level, particularly in the lowest or highest CZR tertile groups. Conclusions Essential metal imbalance may be a determinant of oxidative stress and renal tubular damage in a chronically Cd-exposed population, and proper zinc supplementation will be effective in preventing adverse health effects due to Cd exposure.

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Differences in the susceptibility to cadmium-induced renal tubular damage and osteoporosis according to sex

Cited by 22 publications

References 25 publications

Environmental exposure to arsenic, lead, and cadmium in people living near Janghang copper smelter in Korea

Environmental exposure to arsenic, lead, and cadmium in people living near Janghang copper smelter in Korea

Associations of Low Environmental Exposure to Multiple Metals with Renal Tubular Impairment in Korean Adults

Copper–zinc imbalance induces kidney tubule damage and oxidative stress in a population exposed to chronic environmental cadmium

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