Differences in the prognosis of preeclampsia according to the initial symptoms: A single-center retrospective report

Nakamura, Eishin; Mikami, Yuzuru; Era, Sumiko; Ono, Yoshihisa; Matsunaga, Shigetaka; Nagai, Tatsuo; Saitoh, Masahiro; Baba, Kazunori

doi:10.1016/j.preghy.2019.03.010

Cited by 3 publications

(5 citation statements)

References 14 publications

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“…Preeclampsia was diagnosed, and delivery occurred significantly later among women with P-PE than among those with S-PE in Morikawa et al’s study 2 (Supplemental Fig. 2 B) and among those with H-PE and S-PE in a report by Nakamura et al 25 (Supplemental Fig. 2 C).…”

Section: Discussionmentioning

confidence: 82%

“…However, in that report, P-PE was considered a condition in which the duration of isolated GP was ≥ 3 days, and other preeclampsia (including H-PE and S-PE) was considered the condition in which the duration of isolated GP was ≤ 2 days. In a report of 111 women with preeclampsia who gave birth between 2008 and 2016 at another Japanese institution 25 , Nakamura et al stated that 21 (18.9%) had P-PE, 48 (43.2%) had H-PE, and 42 (37.8%) had S-PE. S-PE was defined as onset of hypertension and proteinuria on the same day or within 2 days of one another after 20 weeks of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, according to Akaishi et al, the pregnancy outcomes in women with P-PE were worse than those in women with H-PE or S-PE 24 . Nakamura et al demonstrated that women with H-PE and S-PE have poorer perinatal prognoses than those with P-PE 25 .…”

Section: Discussionmentioning

confidence: 99%

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Earlier onset of proteinuria or hypertension is a predictor of progression from gestational hypertension or gestational proteinuria to preeclampsia

Morikawa

Mayama

Noshiro

et al. 2021

Sci Rep

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Although gestational hypertension (GH) is a well-known disorder, gestational proteinuria (GP) has been far less emphasized. According to international criteria, hypertensive disorders of pregnancy include GH but not GP. Previous studies have not revealed the predictors of progression from GP to preeclampsia or those of progression from GH to preeclampsia. We aimed to determine both sets of predictors. A retrospective cohort study was conducted with singleton pregnant women who delivered at 22 gestational weeks or later. Preeclampsia was divided into three types: new onset of hypertension/proteinuria at 20 gestational weeks or later and additional new onset of other symptoms at < 7 days or at ≥ 7 days later. Of 94 women with preeclampsia, 20 exhibited proteinuria before preeclampsia, 14 experienced hypertension before preeclampsia, and 60 exhibited simultaneous new onset of both hypertension and proteinuria before preeclampsia; the outcomes of all types were similar. Of 34 women with presumptive GP, 58.8% developed preeclampsia; this proportion was significantly higher than that of 89 women with presumptive GH who developed preeclampsia (15.7%). According to multivariate logistic regression models, earlier onset of hypertension/proteinuria (before or at 34.7/33.9 gestational weeks) was a predicator for progression from presumptive GH/GP to preeclampsia (odds ratios: 1.21/1.21, P value: 0.0044/0.0477, respectively).

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

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Earlier onset of proteinuria or hypertension is a predictor of progression from gestational hypertension or gestational proteinuria to preeclampsia

Morikawa

Mayama

Noshiro

et al. 2021

Sci Rep

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“…On the other hand, PE appears to predispose to the development of spastic CP with unilateral distribution in full-term infants, possibly due to a perinatal ischemic stroke influenced by the characteristic vascular endothelial disorder of PE [34]. Likewise, the systemic inflammation characteristic of PE, similar to sepsis, could also contribute to the onset of CP [34,149].…”

Section: Pe and Cpmentioning

confidence: 99%

Neurodevelopmental Disruptions in Children of Preeclamptic Mothers: Pathophysiological Mechanisms and Consequences

González-Rojas,

Valencia-Narbona

2024

IJMS

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Preeclampsia (PE) is a multisystem disorder characterized by elevated blood pressure in the mother, typically occurring after 20 weeks of gestation and posing risks to both maternal and fetal health. PE causes placental changes that can affect the fetus, particularly neurodevelopment. Its key pathophysiological mechanisms encompass hypoxia, vascular and angiogenic dysregulation, inflammation, neuronal and glial alterations, and disruptions in neuronal signaling. Animal models indicate that PE is correlated with neurodevelopmental alterations and cognitive dysfunctions in offspring and in humans, an association between PE and conditions such as cerebral palsy, autism spectrum disorder, attention deficit hyperactivity disorder, and sexual dimorphism has been observed. Considering the relevance for mothers and children, we conducted a narrative literature review to describe the relationships between the pathophysiological mechanisms behind neurodevelopmental alterations in the offspring of PE mothers, along with their potential consequences. Furthermore, we emphasize aspects pertinent to the prevention/treatment of PE in pregnant mothers and alterations observed in their offspring. The present narrative review offers a current, complete, and exhaustive analysis of (i) the pathophysiological mechanisms that can affect neurodevelopment in the children of PE mothers, (ii) the relationship between PE and neurological alterations in offspring, and (iii) the prevention/treatment of PE.

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“…The pathogenesis of PE is unclear, the important factors are immune imbalance, placental superficial implantation, oxidative stress, thrombosis, and genetic factors ( 2 ). Clinical symptoms include hypertension and obvious proteinuria, vascular endothelial dysfunction, and systemic inflammatory response ( 3 ). In addition, endocrine, genetic, environmental elements, and immune response are intimately associated with the formation and progression of PE ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Methylation-based epigenetic studies and gene integration analysis of preeclampsia

Jiang¹,

Chang²,

Liu³

et al. 2022

Ann Transl Med

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Background: Preeclampsia (PE) is a multi-factor and multi-mechanism disease, which may jeopardize the life safety of affected pregnant women and fetuses. Our study aimed to detect the potential molecular indicators of PE that might be helpful for its diagnosis and treatment.Methods: Methylation assay of PE and normal pregnancies placental biopsies was analyzed using the Illumina Human Methylation-27 Assay. Differentially expressed genes (DEGs) were analyzed using R-DESeq2 software. Subsequently, the relationship between DNA methylation genes and DEGs were evaluated. Furthermore, immunohistochemical (IHC) and quantitative reverse transcription polymerase chain reaction (qRT-PCR) validation analyses were conducted for the hub genes.Results: These hub genes (including PLXNB1, PMCH, PPARG, GOPC, CD79A, and MME) were found to be differentially methylated genes and DEGs. Further analysis revealed that PPARG, CD79A, and PLXNB1 may be diagnostic gene markers for PE; down-regulation of PPARG expression was closely correlated with the development of PE. The IHC analysis demonstrated that the expression levels of PLXNB1, PMCH, GOPC, CD79A, and MME genes were increased, whereas that of PPARG was decreased in PE tissues. The PCR results showed that PLXNB1, PMCH, GOPC, CD79a, and MME were upregulated, whereas PPARG was downregulated. The results of the 2 experiments were consistent with those of bioinformatics analysis. Conclusions:The molecular indicators identified in this study could facilitate the development of potential biomarkers and therapeutic targets for PE.

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Differences in the prognosis of preeclampsia according to the initial symptoms: A single-center retrospective report

Cited by 3 publications

References 14 publications

Earlier onset of proteinuria or hypertension is a predictor of progression from gestational hypertension or gestational proteinuria to preeclampsia

Earlier onset of proteinuria or hypertension is a predictor of progression from gestational hypertension or gestational proteinuria to preeclampsia

Neurodevelopmental Disruptions in Children of Preeclamptic Mothers: Pathophysiological Mechanisms and Consequences

Methylation-based epigenetic studies and gene integration analysis of preeclampsia

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