Differences in the clinical phenotype of adenomyosis and leiomyomas: a retrospective, questionnaire-based study

Böer, B; Wallwiener, Markus; Rom, Joachim; Schoenfisch, Birgitt; Brucker, Sara; Taran, Florin Andrei

doi:10.1007/s00404-013-3141-0

Cited by 14 publications

(12 citation statements)

References 24 publications

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“…Although several studies have suggested that a history of laparotomy and prior uterine surgery (such as cesarean delivery, myomectomy, dilation and curettage) were related to an increased risk of adenomyosis, we did not find statistically significant differences in terms of the history of previous cesarean delivery and laparotomy between the two groups . Hence, our results did not support the hypothesis that surgically‐induced endometrial implantation may contribute to the development of adenomyosis …”

Section: Discussioncontrasting

confidence: 94%

“…were related to an increased risk of adenomyosis, we did not find statistically significant differences in terms of the history of previous cesarean delivery and laparotomy between the two groups. 7,18,19 Hence, our results did not support the hypothesis that surgically-induced endometrial implantation may contribute to the development of adenomyosis. 6 The majority of women with myomas are asymptomatic, but abnormal uterine bleeding, pelvic pain and pelvic pressure are the most common symptoms associated with fibroids.…”

Section: Discussioncontrasting

confidence: 94%

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Differences in clinical characteristics for the determination of adenomyosis coexisting with leiomyomas

Ates

Özcan

Aydın

et al. 2015

J of Obstet and Gynaecol

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Section: Discussioncontrasting

confidence: 94%

Section: Discussioncontrasting

confidence: 94%

Differences in clinical characteristics for the determination of adenomyosis coexisting with leiomyomas

Ates

Özcan

Aydın

et al. 2015

J of Obstet and Gynaecol

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“…[83][84][85] The results for menorrhagia and dysmenorrhea have been less consistent when adenomyosis, or adenomyosis with leiomyomas, has been compared with those with pathology-confirmed leiomyomas. 12,43,[86][87][88][89][90][91][92][93] Although in several of these studies, patients with adenomyosis with or without leiomyomas appear to experience a greater frequency of dysmenorrhea than patients with leiomyomas. 12,86,87,90,92 One frequently cited study has suggested that adenomyosis is an incidental finding and not a source of symptoms.…”

Section: Symptomatologymentioning

confidence: 99%

Epidemiology of Adenomyosis

Upson

Missmer

2020

Semin Reprod Med

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Adenomyosis, characterized by the presence of endometrial glands and stroma within the myometrium, can have a substantial impact on the quality of women's lives. Despite this, the epidemiologic research on this condition lags considerably behind that of other noncancerous reproductive health conditions. The lack of progress and knowledge is due in part to the challenges in designing valid epidemiologic studies, since the diagnosis of adenomyosis historically has been limited to the examination of uterine specimens from hysterectomy. This review describes the available data on the frequency of this condition and the epidemiologic investigation thus far into the risk factors for disease—highlighting the methodologic and inference challenges primarily around study sample selection. We conclude with providing recommendations for approaches to future epidemiologic study that capitalize on the advancements in imaging technology to detect adenomyosis and provide a fuller picture of the occurrence and risk factors for disease.

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“…In 15% to 57% of cases, uterine leiomyomas and adenomyosis coexist in the same uterus and women with both conditions are more likely to experience pelvic pain 57 . Results from a case-control study on women undergoing hysterectomy showed that women with leiomyoma and adenomyosis were more likely to report dysmenorrhea, dyspareunia, and non-cyclic pelvic pain compared with women with leiomyomas only 3, 57, 58 .…”

Section: Coexistence With Other Gynecological Conditionsmentioning

confidence: 99%

Recent advances in understanding and managing adenomyosis

2019

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Adenomyosis is a benign uterine disorder in which endometrial glands and stroma are pathologically demonstrated in the uterine myometrium and it is considered a specific entity in the PALM-COEIN FIGO (polyp; adenomyosis; leiomyoma; malignancy and hyperplasia; coagulopathy; ovulatory dysfunction; endometrial; iatrogenic; and not yet classified – International Federation of Gynecology and Obstetrics) classification of causes of abnormal uterine bleeding (AUB). Although it has always been considered the classic condition of multiparous women over 40 years old who have pain and heavy menstrual bleeding, diagnosed at hysterectomy, the epidemiological scenario has completely changed. Adenomyosis is increasingly identified in young women with pain, AUB, infertility, or no symptoms by using imaging techniques such as transvaginal ultrasound and magnetic resonance. However, there is no agreement on the definition and classification of adenomyotic lesions from both the histopathology and the imaging point of view, and the diagnosis remains difficult and unclear. A uniform and shared reporting system needs to be implemented in order to improve our understanding on imaging features, their relationship with pathogenic theories, and their importance in terms of clinical symptoms and response to treatment. In fact, adenomyosis pathogenesis remains elusive and not a single theory can explain all of the different phenotypes of the disease. Furthermore, adenomyosis often coexists with other gynecological conditions, such as endometriosis and uterine fibroids, increasing the heterogeneity of available data. Treatment requires a lifelong management plan as the disease has a negative impact on quality of life in terms of menstrual symptoms, fertility, and pregnancy outcome and has a high risk of miscarriage and obstetric complications.

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Differences in the clinical phenotype of adenomyosis and leiomyomas: a retrospective, questionnaire-based study

Abstract: Women with a histologic diagnosis of adenomyosis differ from women who have only leiomyomas at the time of hysterectomy.

Cited by 14 publications

References 24 publications

Differences in clinical characteristics for the determination of adenomyosis coexisting with leiomyomas

Differences in clinical characteristics for the determination of adenomyosis coexisting with leiomyomas

Epidemiology of Adenomyosis

Recent advances in understanding and managing adenomyosis

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