Differences in oligoclonal bands and visual evoked potentials in patients with radiologically and clinically isolated syndrome

Gabelić, Tereza; Radmilović, Marin; Posavec, Vanja; Škvorc, Ana; Bošković, Mateja; Adamec, Ivan; Milivojević, Iva; Barun, Barbara; Habek, Mario

doi:10.1007/s13760-012-0106-1

Cited by 24 publications

(20 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, if we are trying to increase the sensitivity of a diagnostic test, we may want to use paraclinical tests that may allow us to detect a higher proportion of patients with asymptomatic optic nerve involvement compared to clinical tools alone. Full-field VEPs have classically been used to provide paraclinical evidence of demyelination to support the diagnosis of MS. 17 Very few studies have assessed VEPs in purely CIS cohorts, [25][26][27][28][29] reporting rates of abnormal VEP results that range from 15% to 49% and that are in line with the abnormal VEP rate of our study (32.5%). As expected, we have found VEPs to be more frequently affected in patients with optic neuritis CIS (66.7%), which is a result similar to that reported in the literature (67.8%-87%).…”

Section: Discussionsupporting

confidence: 83%

Optic Nerve Topography in Multiple Sclerosis Diagnosis

et al. 2021

View full text Add to dashboard Cite

ObjectiveTo assess the added value of the optic nerve region (by using visual evoked potentials [VEPs]) to the current diagnostic criteria.MethodsFrom the Barcelona clinically isolated syndrome (CIS) cohort, patients with complete information to assess dissemination in space (DIS), the optic nerve region, and dissemination in time at baseline (n = 388) were selected. Modified DIS (modDIS) criteria were constructed by adding the optic nerve to the current DIS regions. The DIS and modDIS criteria were evaluated with univariable Cox proportional hazard regression analyses with the time to the second attack as the outcome. A subset of these patients who had at least 10 years of follow-up or a second attack occurring within 10 years (n = 151) were selected to assess the diagnostic performance. The analyses were also performed according to CIS topography (optic neuritis vs non–optic neuritis).ResultsThe addition of the optic nerve as a fifth region improved the diagnostic performance by slightly increasing the accuracy (2017 DIS 75.5%, modDIS 78.1%) and the sensitivity (2017 DIS 79.2%, modDIS 82.3%) without lowering the specificity (2017 DIS 52.4%, modDIS 52.4%). When the analysis was conducted according to CIS topography, the modDIS criteria performed similarly in both optic neuritis and non–optic neuritis CIS.ConclusionThe addition of the optic nerve, assessed by VEP, as a fifth region in the current DIS criteria slightly improves the diagnostic performance because it increases sensitivity without losing specificity.

show abstract

Section: Discussionsupporting

confidence: 83%

Optic Nerve Topography in Multiple Sclerosis Diagnosis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…This observation led to the establishment of the definition of the radiologically isolated syndrome (RIS) (4) as a probable preclinical variant of MS (5, 6). Additionally, a fraction of these patients exhibit oligoclonal bands (OCBs) in the cerebrospinal fluid (CSF), similar to those found in patients with a clinically isolated syndrome (CIS) (7).…”

Section: Introductionmentioning

confidence: 62%

CSF-Progranulin and Neurofilament Light Chain Levels in Patients With Radiologically Isolated Syndrome—Sign of Inflammation

et al. 2018

View full text Add to dashboard Cite

Background: Cerebrospinal fluid (CSF) markers of disease in patients with radiologically isolated syndrome (RIS) are the subject of intense investigation, because they have the potential to enhance our understanding of the natural disease course and provide insights into similarities and differences between RIS and other multiple sclerosis (MS) disease identities.Methods: Here we compared neurofilament light chain (NFL) and progranulin (PGRN) levels in the CSF in RIS patients with levels in patients with different subtypes of MS and healthy controls (HC) using Kruskal–Wallis one-way analysis of variance.Results: Median CSF NFL concentrations in RIS patients did not differ to those in HC and clinically isolated syndrome (CIS) patients, but were significantly lower than in relapsing remitting (RRMS) and primary progressive (PPMS) MS patients. In contrast, RIS patients exhibited higher median CSF PGRN levels than HC and showed no significant differences compared with CIS, RRMS, and PPMS cases.Conclusion: We postulate that elevated PGRN values in the CSF of RIS patients might indicate inflammatory and repair activity prior to axonal disintegration.

show abstract

“…The logistic model was significant, χ 2 (1) = 6.804, P = 0.009. It explained 10.7% (Nagelkerke R2) of the variance in presence of midbrain MR lesions and correctly classified 87% of cases.…”

Section: Resultsmentioning

confidence: 93%

“…Most of CIS patients present with optic neuritis, transverse myelitis, or brainstem/cerebellar symptoms, although a substantial number have multifocal symptoms (1). The affection of the brainstem in MS bears significant clinical importance.…”

mentioning

confidence: 99%

Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome

Skorić¹,

Adamec²,

Crnošija³

et al. 2016

Croat Med J

Self Cite

View full text Add to dashboard Cite

AimTo test the hypothesis that tSSEP findings reflect clinical and MRI MS lesions, the aim of this study was to investigate tSSEP changes in patients with clinically isolated syndrome (CIS) in relation to clinical and brainstem MRI findings. The second aim was to investigate whether the interpretation of the tSSEP results in the form of the tSSEP score enables better evaluation of the afferent trigeminal pathway involvement than analyzing each tSSEP parameter separately.Methods115 consecutive CIS patients were enrolled from August 1, 2014 until March 1, 2016. Facial sensory symptoms and brainstem MRI (1.5 T) lesions were analyzed. tSSEP testing was performed for each patient from the raw tSSEP data. The tSSEP score was calculated separately for the left and right side (according to the cut-off values for absent response and prolonged latency of the main component, P1 (0 = normal response, 1 = prolonged latency, 3 = absent response) and the two values were summed.ResultsThere was no difference in the absolute values of the tSSEP variables regarding the presence of clinical symptoms. No association was found between tSSEP abnormalities and clinical symptoms (P = 0.544). Brainstem lesions (midbrain and pons) were associated with the absent tSSEP responses (P = 0.002 and P = 0.005, respectively). tSSEP score was significantly higher in patients with brainstem lesions (P = 0.01), especially midbrain (P = 0.004) and pontine (P = 0.008) lesions. Binary logistic regression showed that tSSEP score had a significant effect on the likelihood that patients have midbrain MR lesions, χ2(1) = 6.804, P = 0.009; and the model correctly classified 87% of cases.ConclusionsThe consistent finding of this study was the association between tSSEP and midbrain lesions on MRI, indicating that tSSEP evaluates proprioception of the face. This study establishes the value of tSSEP in assessing brainstem function in early multiple sclerosis.

show abstract

Differences in oligoclonal bands and visual evoked potentials in patients with radiologically and clinically isolated syndrome

Cited by 24 publications

References 19 publications

Optic Nerve Topography in Multiple Sclerosis Diagnosis

Optic Nerve Topography in Multiple Sclerosis Diagnosis

CSF-Progranulin and Neurofilament Light Chain Levels in Patients With Radiologically Isolated Syndrome—Sign of Inflammation

Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome

Contact Info

Product

Resources

About