Differences in malignant melanoma between children and adolescents. A 35-year epidemiological study

Berg, Peter A.

doi:10.1001/archderm.133.3.295

Cited by 26 publications

(24 citation statements)

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“…11,23,24 It is noteworthy that associated nevus was related to a significantly lower risk of metastases in our patients. Similarly, it has been observed that melanomas that contain benign melanocytic nevus are relatively thin and have a low metastasis rate 41 ; however, no statistical difference was observed when those tumors were stratified by tumor thickness.…”

Section: Histologic Featuresmentioning

confidence: 52%

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Prognostic factors for melanoma in children and adolescents

Paradela

Fonseca

Pita-Fernández

et al. 2010

Cancer

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BACKGROUND: Cutaneous melanoma in childhood is rare; therefore, its prognostic factors and biologic behavior and the effectiveness of adjuvant diagnostic techniques in this group remain mostly unknown. METHODS: The authors conducted a retrospective, observational study on the prognostic significance of clinical and pathologic findings from 137 cutaneous and mucosal melanomas in patients aged <18 years that were reviewed by the pathology department of a large cancer center during the period from 1992 to 2006. RESULTS: Univariate analysis indicated that there was a significantly greater risk of metastases for patients who had previous nonmelanocytic malignancies, nodular histologic type, fusiform or spitzoid cytology, high Breslow thickness, vertical growth phase, high dermal mitotic activity, ulceration, and vascular invasion. Adjacent nevus and radial growth phase were associated with a better prognosis. Twelve patients (10.3%) died during follow-up. Decreased overall survival was related significantly to age >10 years, previous nonmelanocytic malignancy, high Breslow thickness, high Clark level, and the presence of metastases at diagnosis. All patients who died were aged !11 years, and 8 of those patients had metastases at diagnosis. In multivariate analysis, higher Breslow thickness predicted an increased risk of metastases, whereas age >10 years and the presence of metastases at diagnosis were associated with decreased survival. CONCLUSIONS: Similar to adults, the detection of metastases at diagnosis in children with melanoma was 1 of the main factors that influenced overall survival. Melanomas that were detected in children aged <11 years appeared to have a less aggressive behavior than those detected in adults. Cancer 2010;116:4334-44.

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Section: Histologic Featuresmentioning

confidence: 52%

“…Previous surveys indicated a slight female predominance of melanoma among children. In 2 large studies, 20,21 male sex was associated with worse prognosis, but that finding was not confirmed by cancer registry studies 22,23 or epidemiologic studies. 19 We observed equal distributions for sex and prognosis.…”

Section: Demographic and Clinical Featuresmentioning

confidence: 96%

Prognostic factors for melanoma in children and adolescents

Paradela

Fonseca

Pita-Fernández

et al. 2010

Cancer

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“…[1][2][3][4] Although melanoma in children remains rare, accounting for only approximately 1-3% of all malignancies in children, 5 incidence increases markedly from the teenage years and in Australia, melanoma is now the most common cancer in those between 15-44 years of age. 6 Most studies of melanoma in adolescents have been descriptive case series [7][8][9][10] and little is known of the causes of melanoma in this age group.…”

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confidence: 99%

Melanoma in adolescents: A case‐control study of risk factors in Queensland, Australia

Youl

Aitken

Hayward

et al. 2001

Intl Journal of Cancer

111

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The incidence of melanoma increases markedly in the second decade of life but almost nothing is known of the causes of melanoma in this age group. We report on the first population-based case-control study of risk factors for melanoma in adolescents ( Only 2 of 147 cases tested had germline variants or mutations in CDKN2A. There was no association with sunscreen use overall, however, never/rare use of sunscreen at home under the age of 5 years was associated with increased risk (OR ‫؍‬ 2.2, 95%CI ‫؍‬ 0.7-7.1). There was no difference between cases and controls in cumulative sun exposure in this high-exposure environment. Factors indicating genetic susceptibility to melanoma, in particular, the propensity to develop nevi and freckles, red hair, blue eyes, inability to tan and a family history of the disease are the primary determinants of melanoma among adolescents in this high solar radiation environment. Lack of association with reported sun exposure is consistent with the high genetic susceptibility in this group.

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“…We diagnosed MM in 5 pubertal patients younger than 20 years old. The incidence of MM in this age group is apparently increasing in Europe [11]. …”

Section: Discussionmentioning

confidence: 99%

“…For several decades, the number of nonmelanoma skin cancers in the white population of the USA has constituted more than half of all other cancers combined [1, 2, 3]. During that period of time, the incidences of basal cell carcinomas (BCC), squamous cell carcinomas (SCC) and malignant melanomas (MM) have continued to be on the rise worldwide [2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13]. The information from the Belgian National Cancer Registry contrasts with such epidemiological data [14].…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Cancers in the Mosan Region and Ardennes of Belgium

Piérard-Franchimont

Uhoda²,

Pierard³

1999

Dermatology

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Background: The ratios of basal cell carcinomas (BBC) to squamous cell carcinomas (SCC) and to malignant melanomas (MM) have changed over time in the white population throughout the world. Objective: To evaluate the incidence of skin cancers in the Mosan region and the Belgian Ardennes over the past 6 years. Results: In contrast with epidemiological data reported by the Belgian National Cancer Registry, cutaneous cancers are the commonest malignancies occurring in humans. At the present time, the ratio BCC:SCC roughly equals 4 to 1. When combined, the incidence of BCC and SCC is about 10 times greater than that of MM. Conclusion: The rate of detection of skin cancers does not always correlate with the rate of notification of a national registry.

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Differences in malignant melanoma between children and adolescents. A 35-year epidemiological study

Cited by 26 publications

References 0 publications

Prognostic factors for melanoma in children and adolescents

Prognostic factors for melanoma in children and adolescents

Melanoma in adolescents: A case‐control study of risk factors in Queensland, Australia

Cutaneous Cancers in the Mosan Region and Ardennes of Belgium

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