“…The responses were depressed to various extents by the different models, but were normalized after treatment with STW5 in both RS and the sequential model. The differences in contractile responses for acetylcholine and serotonin have been reported earlier (Mukai and Kubota 1980). In addition to the agents known to affect accommodation by acting on specific receptors, the effect of KCl was also studied.…”
The sequential stress model has a place in drug screening for potential usefulness in FD as it simulates more the clinical setting. Furthermore, the findings shed more light on the mechanisms of action of STW5 in FD.
“…The responses were depressed to various extents by the different models, but were normalized after treatment with STW5 in both RS and the sequential model. The differences in contractile responses for acetylcholine and serotonin have been reported earlier (Mukai and Kubota 1980). In addition to the agents known to affect accommodation by acting on specific receptors, the effect of KCl was also studied.…”
The sequential stress model has a place in drug screening for potential usefulness in FD as it simulates more the clinical setting. Furthermore, the findings shed more light on the mechanisms of action of STW5 in FD.
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