Differences Among Epileptics and Between Epileptics and Nonepileptics in Terms of Some Memory and Learning Variables

The Neuropsychology of Attention

“…However, this relationship is quite variable, as there is not necessarily a direct relationship between the severity of the seizures and cognitive deficits. Memory impairments are often noted in patients with epilepsy (Deutsch, 1953;Loiseau, Stube, Broustet, Batteleochi, Gomeni, & Morselli, 1980;Rausch, Lief, & Crandall, 1978). The type of memory deficit detected correlates with the side of the lesion in patients undergoing unilateral craniotomy (Milner, 1965), but may correspond only moderately with the exact sites of seizure foci (Fedio & Mirsky, 1969).…”

The Neuropsychology of Attention

“…However, this relationship is quite variable, as there is not necessarily a direct relationship between the severity of the seizures and cognitive deficits. Memory impairments are often noted in patients with epilepsy (Deutsch, 1953;Loiseau, Stube, Broustet, Batteleochi, Gomeni, & Morselli, 1980;Rausch, Lief, & Crandall, 1978). The type of memory deficit detected correlates with the side of the lesion in patients undergoing unilateral craniotomy (Milner, 1965), but may correspond only moderately with the exact sites of seizure foci (Fedio & Mirsky, 1969).…”

Anticonvulsant Drugs and Cognitive Function: A Review of the Literature

“…A major difficulty in evaluating the literature in relationship to these is that they most likely represent problems with multiple determinants, which, in patient studies, are difficult to disentangle. In an early investigation, Deutsch (1953) assessed the memory skills of 90 patients, 30 with epilepsy and brain damage, 30 wjlh epilepsy and no brain damage, and 30 with brain damage and no epilepsy. Both groups with epilepsy showed a similar pattern of deficits on tests of learning and memory, including impairments in tactile learning and auditory perceptual tasks, which was different from that observed in the brain damaged groups.…”

A Comparative Study of the Cognitive Effects of Phenytoin and Carbamazepine in New Referrals with Epilepsy

“…Several different biological and psychosocial factors may contribute to impairment of cognitive functions, mood, and behavior in epileptic subjects (Pond, 1981;Reynolds, 1981). The factors that may specifically influence cognitive function include underlying structural brain lesions (Dikman, 1980), temporal lobe pathology or dysfunction (Deutsch, 1953;Glowinski, 1973;Delaney et al, 1980), the age of onset, the duration of epilepsy and the frequency of seizures (Dikman, 1980), the influence of "subclinical" abnormal electrical activity (Hutt, '1979), and anticonvulsant drug therapy (Trimble and Reynolds, 1976;Thompson, 1981 ;Reynolds, 1983;Trimble and Reynolds, 1984). This report presents further observations on the effect of anticonvulsant drugs on cognitive function.…”

The Neuropsychology of Attention

“…However, this relationship is quite variable, as there is not necessarily a direct relationship between the severity of the seizures and cognitive deficits. Memory impairments are often noted in patients with epilepsy (Deutsch, 1953;Loiseau, Stube, Broustet, Batteleochi, Gomeni, & Morselli, 1980;Rausch, Lief, & Crandall, 1978). The type of memory deficit detected correlates with the side of the lesion in patients undergoing unilateral craniotomy (Milner, 1965), but may correspond only moderately with the exact sites of seizure foci (Fedio & Mirsky, 1969).…”

Anticonvulsant Drugs and Cognitive Function: A Review of the Literature

“…A major difficulty in evaluating the literature in relationship to these is that they most likely represent problems with multiple determinants, which, in patient studies, are difficult to disentangle. In an early investigation, Deutsch (1953) assessed the memory skills of 90 patients, 30 with epilepsy and brain damage, 30 wjlh epilepsy and no brain damage, and 30 with brain damage and no epilepsy. Both groups with epilepsy showed a similar pattern of deficits on tests of learning and memory, including impairments in tactile learning and auditory perceptual tasks, which was different from that observed in the brain damaged groups.…”

A Comparative Study of the Cognitive Effects of Phenytoin and Carbamazepine in New Referrals with Epilepsy

“…Several different biological and psychosocial factors may contribute to impairment of cognitive functions, mood, and behavior in epileptic subjects (Pond, 1981;Reynolds, 1981). The factors that may specifically influence cognitive function include underlying structural brain lesions (Dikman, 1980), temporal lobe pathology or dysfunction (Deutsch, 1953;Glowinski, 1973;Delaney et al, 1980), the age of onset, the duration of epilepsy and the frequency of seizures (Dikman, 1980), the influence of "subclinical" abnormal electrical activity (Hutt, '1979), and anticonvulsant drug therapy (Trimble and Reynolds, 1976;Thompson, 1981 ;Reynolds, 1983;Trimble and Reynolds, 1984). This report presents further observations on the effect of anticonvulsant drugs on cognitive function.…”

The Neuropsychology of Attention

“…However, this relationship is quite variable, as there is not necessarily a direct relationship between the severity of the seizures and cognitive deficits. Memory impairments are often noted in patients with epilepsy (Deutsch, 1953;Loiseau, Stube, Broustet, Batteleochi, Gomeni, & Morselli, 1980;Rausch, Lief, & Crandall, 1978). The type of memory deficit detected correlates with the side of the lesion in patients undergoing unilateral craniotomy (Milner, 1965), but may correspond only moderately with the exact sites of seizure foci (Fedio & Mirsky, 1969).…”

Anticonvulsant Drugs and Cognitive Function: A Review of the Literature

“…A major difficulty in evaluating the literature in relationship to these is that they most likely represent problems with multiple determinants, which, in patient studies, are difficult to disentangle. In an early investigation, Deutsch (1953) assessed the memory skills of 90 patients, 30 with epilepsy and brain damage, 30 wjlh epilepsy and no brain damage, and 30 with brain damage and no epilepsy. Both groups with epilepsy showed a similar pattern of deficits on tests of learning and memory, including impairments in tactile learning and auditory perceptual tasks, which was different from that observed in the brain damaged groups.…”

A Comparative Study of the Cognitive Effects of Phenytoin and Carbamazepine in New Referrals with Epilepsy

“…Several different biological and psychosocial factors may contribute to impairment of cognitive functions, mood, and behavior in epileptic subjects (Pond, 1981;Reynolds, 1981). The factors that may specifically influence cognitive function include underlying structural brain lesions (Dikman, 1980), temporal lobe pathology or dysfunction (Deutsch, 1953;Glowinski, 1973;Delaney et al, 1980), the age of onset, the duration of epilepsy and the frequency of seizures (Dikman, 1980), the influence of "subclinical" abnormal electrical activity (Hutt, '1979), and anticonvulsant drug therapy (Trimble and Reynolds, 1976;Thompson, 1981 ;Reynolds, 1983;Trimble and Reynolds, 1984). This report presents further observations on the effect of anticonvulsant drugs on cognitive function.…”