Dietary zinc oxide nanoparticles as growth promoter for weanling pigs

Milani, Natália Cristina; Sbardella, Maicon; Ikeda, Natália Y.; Arno, Alessandra; Mascarenhas, Bruno Cano; Miyada, Valdomiro Shigueru

doi:10.1016/j.anifeedsci.2017.03.001

Cited by 46 publications

(37 citation statements)

References 44 publications

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“…1. In practice, pharmacological dose of Zn is widely supple mented in weaned pig diets to enhance the growth performance and, more importantly, to reduce the incidence of postwean ing diarrhea, which has been widely reported [6,15]. In our study, pigs fed diets supplemented with TBZC showed sig nificantly lower diarrhea incidence than those fed the basal diet, indicating that TBZC is an effective Zn source in diarrhea alleviation, which is consistent with another study focusing on dietary TBZC supplementation and fecal scores [6].…”

Section: Discussionmentioning

confidence: 99%

Moderate tetrabasic zinc chloride supplementation improves growth performance and reduces diarrhea incidence in weaned pigs

Zhang

Xia

Zhao

et al. 2020

Asian-Australas J Anim Sci

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Objective: Two experiments were conducted to evaluate tetrabasic zinc chloride (TBZC) on the health of weaned pigs, and to determine the optimal supplemental concentrations and whether dietary TBZC could replace the pharmacological concentrations of dietary zinc oxide (ZnO) to improve growth performance and decrease Zn excretion in weaned pigs. Methods: In Exp. 1, 180 weaned pigs (8.92±1.05 kg body weight [BW]) were randomly assigned to 1 of 5 treatments, including the basal diet containing 125 mg/kg zinc sulfate (ZnSO 4), and the basal diet with 1,200, 1,800, 2,400, or 3,000 mg/kg TBZC supplementation. In Exp. 2, 240 weaned pigs (7.66±1.09 kg BW) were randomly assigned to 1 of 5 treatments, including a negative control diet without Zn supplementation, a positive control diet (2,250 mg/kg ZnO), and 3 experimental diets with different concentrations of TBZC supplemen tation (1,000, 1,250, and 1,500 mg/kg). Results: In Exp. 1, the average daily gain (ADG), feed efficiency (G:F) and diarrhea incidence responded quadratically (p<0.01) as the TBZC supplemental concentrations increased, and pigs fed 1,200 and 1,800 mg/kg TBZC showed the best growth performance. Moreover, 1,800 mg/kg TBZC supplementation showed the greatest (p<0.01) total antioxidant capacity and glutathione peroxidase activities in liver of pigs. Histopathological examination revealed lesions in heart, liver, lung and kidney, and mild or severe histological lesions mainly occurred with the supplementation of 2,400 and 3,000 mg/kg TBZC. In Exp. 2, 1,000 and 1,250 mg/kg TBZC supplementation in diets significantly (p<0.01) increased ADG and G:F of weaned pigs, reduced Zn excretion in feces, and had no effect on diarrheareducing compared to 2,250 mg/kg ZnO supplementation. Conclusion: The TBZC is a potential alternative to ZnO. The recommended concentration of TBZC in weaned pig diets is 1,000 to 1,250 mg/kg.

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Section: Discussionmentioning

confidence: 99%

Moderate tetrabasic zinc chloride supplementation improves growth performance and reduces diarrhea incidence in weaned pigs

Zhang

Xia

Zhao

et al. 2020

Asian-Australas J Anim Sci

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“…Li et al [53] showed that dietary supplementation with nanoparticles of zinc oxide can increase zinc digestibility, serum growth hormone levels and enhance the immune response of weaning piglets. On the other hand, Milani et al [54] did not find an effect of ZnO nanoparticles on pigs' growth performance, except for the gain:feed ratio and diarrhea occurrence that improved linearly over days 1-7 of the experimental period. The effect of nano Zn as a feed additive was also tested in a study in cows, which led to improved immunological response and consequently reduced somatic cell count in subclinical mastitis [55].…”

Section: The Potential Use Of Nano-silica In Animal Nutritionmentioning

confidence: 90%

The Membrane Interactions of Nano-Silica and Its Potential Application in Animal Nutrition

Pieszka

Bederska‐Łojewska

Szczurek

et al. 2019

Animals

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Nanoparticles are increasingly popular in numerous fields including electronics, optics and medicine (vaccines, tissue engineering, microsurgery, genomics and cancer therapies). The most widely used nanoparticles in biomedical applications are those designed by man. Scientists have obtained many types of silica nanoparticles with defined shape and chemical composition, but different properties and applications. Nanoparticles include particles with at least one dimension ranging from 1–100 nm. Silica nanoparticles (Sn), reaching values from several dozen to several hundred m2/g, have unique physicochemical properties due to their porous structure and well-developed specific surface. Currently, the use of Sn in animal nutrition, with a focus on gastrointestinal tract function, is of great interest.

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“…ZnO had no effect on the number of E. coli in feces (Broom, Miller, Kerr, & Knapp, 2006) or the small intestine (Sawai, 2003), but reduced Clostridium in proximal colon (Hu et al, 2012 C. leptum subgroup, while had no effect on that of E. coli. Milani et al (2017) also reported that pigs fed dietary pharmacological level of ZnO had no effects on E. coli colonies counts in the jejunum and cecum. In addition, a reduction in Lactobacillus spp.…”

Section: Discussionmentioning

confidence: 96%

“…coccoides, and C. leptum subgroup, while had no effect on that of E. coli . Milani et al () also reported that pigs fed dietary pharmacological level of ZnO had no effects on E . coli colonies counts in the jejunum and cecum.…”

Section: Discussionmentioning

confidence: 98%

The effects of dietary supplementation with porous zinc oxide on growth performance, intestinal microbiota, morphology, and permeability in weaned piglets

Peng

Chen

Yao

et al. 2019

Animal Science Journal

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The objective of this experiment was to evaluate the effects of dietary supplementation with porous zinc oxide (HiZox) on growth performance, intestinal microbiota, morphology, and permeability in weaned piglets. A total of 128 weaned piglets [(Landrace × Yorkshire) × Duroc] with an average body weight (BW) of (6.55 ± 0.25 kg; 21 d of age) were randomly assigned to four dietary treatments: (1) a corn‐soybean basal diet; (2) basal diet + 3,000 mg/kg conventional ZnO; (3) basal diet + 200 mg/kg HiZox; (4) basal diet + 500 mg/kg HiZox. The experiments lasted for 28 days. Incremental HiZox in the diet increased ADG (linear p = 0.015; quadratic p = 0.043) and ADFI (linear p = 0.027; quadratic p = 0.038), and the diarrhea index decreased linearly and quadratically (p < 0.01) as HiZox supplemented increased. Furthermore, supplementation with HiZox increased the amounts of Lactobacillus spp. (p < 0.05) in the ileum and cecum in comparison with that of control treatment or 3,000 mg/kg ZnO treatment, while decreased the populations of Escherichia coli, Clostridium coccoides, and Clostridium. leptum subgroup (p < 0.05) in the ileum and cecum relative to those in control treatment. The addition of HiZox increased the villus height and villus‐to‐crypt ratio (VC) of duodenum, jejunum, and ileum (p < 0.05), while decreased the crypt depth of jejunum (p < 0.05) and tended to reduce the crypt depth of duodenum (p < 0.10) compared with the control treatment. Piglets fed with 500 mg/kg HiZox had lower serum D‐lactate and diamine oxidase (DAO) than those fed with basal control diet or 3,000 mg/kg ZnO diet (p < 0.01). The results suggested that supplementation with HiZox modulated intestinal microbial composition and improved intestinal morphology, which may exert protective effects on the integrity of the mucosal barrier function of weaned piglets, was as efficacious as pharmaceutical doses of ZnO in enhancing growth performance, indicating that the HiZox may be a promising alternative to pharmaceutical doses of ZnO.

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Dietary zinc oxide nanoparticles as growth promoter for weanling pigs

Cited by 46 publications

References 44 publications

Moderate tetrabasic zinc chloride supplementation improves growth performance and reduces diarrhea incidence in weaned pigs

Moderate tetrabasic zinc chloride supplementation improves growth performance and reduces diarrhea incidence in weaned pigs

The Membrane Interactions of Nano-Silica and Its Potential Application in Animal Nutrition

The effects of dietary supplementation with porous zinc oxide on growth performance, intestinal microbiota, morphology, and permeability in weaned piglets

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