Dietary uptake models used for modeling the bioaccumulation of organic contaminants in fish

Barber, M. Craig

doi:10.1897/07-462.1

Cited by 69 publications

(53 citation statements)

References 163 publications

(328 reference statements)

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“…Although studies of allometric scaling in fish are complicated by confounding influences of temperature, pH, and other factors, numerous studies have shown that intraspecific metabolic rate (measured as resting oxygen consumption) tends to scale to a fractional exponent of body weight, typically ranging from 0.6 to 0.9 when expressed on a whole-animal basis [42][43][44][45][46][47][48]. Allometric relationships containing similar exponents also figure prominently in many published models for chemical accumulation by fish, reflecting assumed or characterized relationships between fish size and biological determinants of chemical flux, including gill ventilation volume, cardiac output, food consumption rate, and absorptive surface area [49][50][51].…”

Section: Discussionmentioning

confidence: 95%

Toward improved models for predicting bioconcentration of well‐metabolized compounds by rainbow trout using measured rates of in vitro intrinsic clearance

Nichols¹,

Huggett²,

Arnot³

et al. 2013

Enviro Toxic and Chemistry

112

251

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Models were developed to predict the bioconcentration of well-metabolized chemicals by rainbow trout. The models employ intrinsic clearance data from in vitro studies with liver S9 fractions or isolated hepatocytes to estimate a liver clearance rate, which is extrapolated to a whole-body biotransformation rate constant (kMET ). Estimated kMET values are then used as inputs to a mass-balance bioconcentration prediction model. An updated algorithm based on measured binding values in trout is used to predict unbound chemical fractions in blood, while other model parameters are designed to be representative of small fish typically used in whole-animal bioconcentration testing efforts. Overall model behavior was shown to be strongly dependent on the relative hydrophobicity of the test compound and assumed rate of in vitro activity. The results of a restricted sensitivity analysis highlight critical research needs and provide guidance on the use of in vitro biotransformation data in a tiered approach to bioaccumulation assessment.

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Section: Discussionmentioning

confidence: 95%

Toward improved models for predicting bioconcentration of well‐metabolized compounds by rainbow trout using measured rates of in vitro intrinsic clearance

Nichols¹,

Huggett²,

Arnot³

et al. 2013

Enviro Toxic and Chemistry

112

251

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show abstract

“…fed copepods (Reinfelder and Fisher 1994). Dietary uptake models for organic contaminants in fish have been reviewed by Barber (2008), where assimilation efficiencies ranged from 40% to 100%. Assimilation efficiencies of chemicals must be distinguished from assimilation efficiencies of food components such as lipids.…”

Section: Toxicokineticsmentioning

confidence: 99%

“…For example, even the fundamentals of how different types of circulatory systems, presence or absence of barriers separating the site of action from the rest of the organism, or characteristics of specific organs affect the distribution of contaminants are unknown. Once further relevant traits and their relationship to internal distribution are identified, these may be linked to pharmacokinetic models, such as the physiologically-based pharmacokinetic (PBPK) and adsorption distribution metabolism excretion (ADME) models (Barber 2008) or dynamic energy budget models (DEB) (Kooijman and Bedaux 1996), which are well developed for some model systems but are rarely applied to nonmodel species because of their high data demand. In contrast, processes of active biological transport may be very suitable to incorporate into these types of models.…”

Section: Toxicokineticsmentioning

confidence: 99%

Framework for traits‐based assessment in ecotoxicology

Rubach

Ashauer

Buchwalter

et al. 2011

Integr Envir Assess & Manag

136

151

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A key challenge in ecotoxicology is to assess the potential risks of chemicals to the wide range of species in the environment on the basis of laboratory toxicity data derived from a limited number of species. These species are then assumed to be suitable surrogates for a wider class of related taxa. For example, Daphnia spp. are used as the indicator species for freshwater aquatic invertebrates. Extrapolation from these datasets to natural communities poses a challenge because the extent to which test species are representative of their various taxonomic groups is often largely unknown, and different taxonomic groups and chemicals are variously represented in the available datasets. Moreover, it has been recognized that physiological and ecological factors can each be powerful determinants of vulnerability to chemical stress, thus differentially influencing toxicant effects at the population and community level. Recently it was proposed that detailed study of species traits might eventually permit better understanding, and thus prediction, of the potential for adverse effects of chemicals to a wider range of organisms than those amenable for study in the laboratory. This line of inquiry stems in part from the ecology literature, in which species traits are being used for improved understanding of how communities are constructed, as well as how communities might respond to, and recover from, disturbance (see other articles in this issue). In the present work, we develop a framework for the application of traits-based assessment. The framework is based on the population vulnerability conceptual model of Van Straalen in which vulnerability is determined by traits that can be grouped into 3 major categories, i.e., external exposure, intrinsic sensitivity, and population sustainability. Within each of these major categories, we evaluate specific traits as well as how they could contribute to the assessment of the potential effects of a toxicant on an organism. We then develop an example considering bioavailability to explore how traits could be used mechanistically to estimate vulnerability. A preliminary inventory of traits for use in ecotoxicology is included; this also identifies the availability of data to quantify those traits, in addition to an indication of the strength of linkage between the trait and the affected process. Finally, we propose a way forward for the further development of traits-based approaches in ecotoxicology.

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“…For model applications, G Feed is obtained from a bioenergetics submodel and may be variable over time [13,14]. The dietary AE is chemical specific and considered to be a constant under thermodynamic model formulations that consider dietary uptake and fecal egestion as separate processes [12]. However, empirical measurements demonstrate considerable variability in the magnitude of AE (20 to >90%) across different studies and diet types [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

The influence of diet on the assimilation efficiency of 47 polychlorinated biphenyl congeners in Japanese koi (Cyprinus carpio)

Liu

Haffner

Drouillard

2009

Enviro Toxic and Chemistry

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The influence of diet on polychlorinated biphenyl (PCB) assimilation was investigated by measuring dietary assimilation efficiencies (AEs) for 47 PCB congeners in juvenile koi (Cyprinus carpio) fed five experimental diets. Two of the diets were naturally contaminated and were obtained by collecting mayflies from Lake Erie (ON, Canada) and emerald shiners from the Detroit River (MI, USA). The remaining diets consisted of commercial fish pellets (lipid contents from 6.7 to 24%) that were contaminated by spiking with a PCB mixture. Experimental fish were held individually to quantify the amount of food consumed per fish and, following a 48-h fasting period to facilitate food digestion and assimilation; AEs were determined by mass balance. Fish fed the benthic invertebrate food exhibited the highest PCB AEs (70-101%) and were significantly elevated compared to the other diet treatments (AEs ranging from 23 to 87%). The PCB AEs for fish fed emerald shiners did not differ from those fed pellet formulations. Variation among PCB AEs was not related to diet lipid content. For all diet treatments, PCB AEs were significantly related to chemical hydrophobicity. The relationship between chemical AE and n-octanol/water partition coefficient (K(OW)) was best explained by a linear model compared to a two-phase resistance model. Overall, PCB AEs were observed to be dependent on both diet type and chemical hydrophobicity, with both factors contributing nearly equally to the variation measured in this toxicokinetic parameter.

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Dietary uptake models used for modeling the bioaccumulation of organic contaminants in fish

Cited by 69 publications

References 163 publications

Toward improved models for predicting bioconcentration of well‐metabolized compounds by rainbow trout using measured rates of in vitro intrinsic clearance

Toward improved models for predicting bioconcentration of well‐metabolized compounds by rainbow trout using measured rates of in vitro intrinsic clearance

Framework for traits‐based assessment in ecotoxicology

The influence of diet on the assimilation efficiency of 47 polychlorinated biphenyl congeners in Japanese koi (Cyprinus carpio)

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