Dietary Supplements and Hypertension: Potential Benefits and Precautions

Rasmussen, Carly B.; Glisson, James; Minor, Deborah S.

doi:10.1111/j.1751-7176.2012.00642.x

Cited by 44 publications

(25 citation statements)

References 20 publications

(42 reference statements)

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“…3,4 Several dietary supplements are currently marketed for the management of hypertension, but the evidence for effectiveness is conflicting. 5 One such supplement thought to have an antihypertensive effect is chlorogenic acid (CGA).…”

Section: Introductionmentioning

confidence: 99%

The effect of chlorogenic acid on blood pressure: a systematic review and meta-analysis of randomized clinical trials

et al. 2014

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Several dietary supplements are currently marketed for management of hypertension, but the evidence for effectiveness is conflicting. Our objective was to critically appraise and evaluate the evidence for the effectiveness of chlorogenic acids (CGAs) on blood pressure, using data from published randomized clinical trials (RCTs). Electronic searches were conducted in Medline, Embase, Amed, Cinahl and The Cochrane Library. We also hand-searched the bibliographies of all retrieved articles. Two reviewers independently determined the eligibility of studies and extracted the data. The reporting quality of all included studies was assessed by the use of a quality assessment checklist adapted from the Consolidated Standard of Reporting Trials Statement. Disagreements were resolved through discussion. Seven eligible studies were identified, and five including 364 participants were included. There were variations in the reporting quality of the included RCTs. Meta-analysis revealed a statistically significant reduction in systolic blood pressure in favour of CGA (mean difference (MD): -4.31 mm Hg; 95% confidence interval (CI): -5.60 to -3.01; I(2)=65%; P<0.00001). Meta-analysis also showed a significant reduction in diastolic blood pressure favouring CGA (MD: -3.68 mm Hg; 95% CI: -3.91 to -3.45; I(2)=97%; P<0.00001). All studies reported no adverse events. In conclusion, the evidence from published RCTs suggests that CGA intake causes statistically significant reductions in systolic and diastolic blood pressures. The size of the effect is moderate. Few clinical trials have been conducted; they vary in design and methodology and are confined to Asian populations and funded by CGA manufacturers. Large independent trials evaluating the effects of CGA on blood pressure are warranted.

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Section: Introductionmentioning

confidence: 99%

The effect of chlorogenic acid on blood pressure: a systematic review and meta-analysis of randomized clinical trials

et al. 2014

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“…Regarding the BP lowering effect of garlic, two systematic reviews and metaanalyses showed that garlic was better than placebo in reducing the BP, 21,22 whereas its cholesterol-lowering properties were no better than placebo. 23 In their review of the subject, Rasmussen et al 24 state that based on the inconsistencies of the effect of garlic on BP, it is difficult at this time to recommend its use for the treatment of HTN. With respect to drug interactions, the administration of garlic in patients with CVD receiving anticoagulants should be avoided for the danger of bleeding, because of its platelet antiaggregatory effects.…”

Section: St John's Wort (Hypericum Perforatum)mentioning

confidence: 98%

The clinical significance and costs of herbs and food supplements used by complementary and alternative medicine for the treatment of cardiovascular diseases and hypertension

Chrysant

2015

J Hum Hypertens

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Complementary and alternative medicine (CAM) is widely used by people in the United States and other countries for the treatment of health conditions that include hypertension (HTN), cardiovascular disease (CVD), heart failure, hyperlipidemia and other condtions. The visits to CAM practitioners result in significant out-of-pocket expenses, as CAM is not covered by health insurance in the majority of cases. The reasons for this are that the products used are not closely regulated by governmental regulatory agencies and lack scientific evidence about their effectiveness and safety. The people regard these products as being 'natural' and, consequently, safe. However, there is evidence that these products can be contaminated and adulterated with other substances and could cause harm to the persons who take them. The responsibility falls on the health professionals, who should become familiar with the various CAM products, inquire their patients whether they taking any of these products and advise them accordingly. This review is based on a recent statement issued by the American Medical for the use of CAM for the treatment of HTN. For its preparation, a Medline search of the English language literature was performed between 2010 and 2014 restricted in the use of CAM for CVD and HTN, and from the 88 abstracts reviewed, 23 pertinent papers were selected. These papers together with collateral literature will be discussed in this review regarding CAM and CAM products on their effectiveness and safety for the treatment of CVD and HTN.

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“…Although, pharmacists advised caution in hypertensive patients because it has been documented to cause increase in blood pressure, tachycardia, and palpitations (Rasmussen et al, 2012). Elevated serum digoxin levels were reported in a patient taking digoxin and Siberian ginseng (McRae, 1996), but the case was debatable, the critics suggesting a possible botanical misidentification by clinical investigators (Awang, 1996).…”

Section: Safetymentioning

confidence: 99%

Osteoprotective Medicinal Plants - Part 1 (A Human Clinical Evidence-Based Review)

Dragoș¹,

Gîlcă²,

Găman³

et al. 2017

Afr J Tradit Complement Altern Med

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Background. Osteoporosis is a bone metabolic disease affecting a large percentage of aging population, which leads to an increased risk of fractures and has a negative impact on life quality. The available treatments for osteoporosis are effective, but are associated with several severe adverse reactions, hence the interest for alternative treatments devoid of such redoubtable side effects. Medicinal plants represent a viable resource for new therapeutic agents. The purpose of this review is to provide an overview about the medicinal plants that have been reported to have antiosteoporotic effects in human clinical studies. Materials and Methods. Relevant studies found in PubMed database, pertaining to efficacy in humans, mechanism of action, osteoactive phytochemicals and safety, were selected. For the inquiry, keywords such as "medicinal plant", "osteoporosis", "bone", "fracture", "osteoclast" and "osteoblast" were used in various combinations. The information extracted was integrated with the traditional knowledge on the correspondent medicinal plants. List of abbreviations: BMD-bone mineral density; CQ-Cissus quadrangularis; CR-Cimicifuga racemose; ESEleutherococcus senticosus; IGF-insulin like growth factor; OPG-osteoprotegerin; OVX-M -ovariectomized mice; OVX-R-ovariectomized rats; PC -Pueraria candollei; PL -Pueraria lobate; PN-Panax notoginseng; RANK-receptor activator of NF-kB; RANKL-receptor activator of NF-kB ligand; ROS -reactive oxygen species; Runx 2-runt related transcription factor 2; SM-Salvia milthiorriza Results. Eight medicinal plants (Cimicifuga racemosa, IntroductionOsteoporosis and osteopenia (low bone density) are bone metabolic diseases affecting a large percentage of aging population, increasing the risk of fractures and having a negative impact on quality of life patients. Risk factors for osteoporosis are: hormonal related risk factors (menopausal and andropausal hormonal disturbances, early menopause, Article HistoryReceived: Jan. 5, 2017. Revised Received: Apr. 7, 2017. Accepted Apr. 12, 2017. Published Online: Nov. 15, 2017 103 hyperparathyroidism, hyperthyroidism), environmental related risk factors (e.g. dioxin-related compounds, heavy metals), nutrition-related risk factors (vitamin D, calcium deficiencies), lifestyle related risk factors (e.g. smoking, sedentarism), drugs (corticosteroids, anticonvulsants, aromatase inhibitors, gonadotropin-releasing hormone agonists), advanced age, female gender (Gonzalez-Macias et al., 2015;Paunescu et al., 2013;Rzymski et al., 2015).Osteoporosis is caused by disturbances of bone remodeling process. The bone tissue is undergoing permanent build-up by osteoblasts and breakdown by osteoclasts. A good dynamic balance between the osteoblastogenesis and osteoclastogenesis is the key for a bone matrix of a high quality. The disbalance occurs especially when the breakdown process overwhelms the building process, being triggered by the risk factors (Leung and Siu, 2013).There are several factors important for osteoblastogenesis, such as run...

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Dietary Supplements and Hypertension: Potential Benefits and Precautions

Cited by 44 publications

References 20 publications

The effect of chlorogenic acid on blood pressure: a systematic review and meta-analysis of randomized clinical trials

The effect of chlorogenic acid on blood pressure: a systematic review and meta-analysis of randomized clinical trials

The clinical significance and costs of herbs and food supplements used by complementary and alternative medicine for the treatment of cardiovascular diseases and hypertension

Osteoprotective Medicinal Plants - Part 1 (A Human Clinical Evidence-Based Review)

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