Dietary supplementation of encapsulated organic acids enhances performance and modulates immune regulation and morphology of jejunal mucosa in piglets

Papadopoulos, Georgios A.; Poutahidis, Theofilos; N, Tallarico; Hardas, Alexandros; Teliousis, Konstantinos; Arsenos, G.; Fortomaris, P.

doi:10.1016/j.rvsc.2017.04.014

Cited by 13 publications

(9 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Changes in dietary and environmental factors by weaning cause a significant morphological and functional alteration in the gastrointestinal tract, known as weaning-associated intestinal inflammation. In the postweaning period, piglets have characteristic chronic enteritis with a variety of inflammatory cells, especially mononuclear cell infiltration in LP [32,33]. e authors of this research study observed eosinophil leukocytes infiltration in LP, although the presence of parasites in the small intestine was not detected.…”

Section: Discussionmentioning

confidence: 61%

“…Nevertheless, after probiotics administration, the increased number of T cells in LP is often associated with an increased Treg [48,80]. Several reports about the ability of probiotics to increase the count of IEL in the small and large intestines of piglets have been published [33,83]. In pigs, IELs are mainly CD8 + [72,84].…”

Section: Veterinary Medicine Internationalmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Probiotics and Herbal Products on Intestinal Histomorphological and Immunological Development in Piglets

Gāliņa

Ansonska

Valdovska

2020

Veterinary Medicine International

View full text Add to dashboard Cite

The aim of the study was to evaluate the effect of probiotics and herbal products on the intestinal histomorphological and immunological development in piglets. Accordingly, 2-week-old piglets were allocated in 4 groups: C (basal diet), Pro (basal diet + probiotics), Pro+B (basal diet + probiotics + buckwheat bran), and H (powder of herbs). After 6 weeks of the experiment, 4 piglets from each experimental group were randomly selected and slaughtered at a slaughterhouse. Samples of tissue and digestive content from the jejunum and colon were collected for bacteriological, histological, and immunohistochemical examination. The results showed that probiotics increased the number of Lactobacillus spp. in the small p<0.05 and large intestines. The intestinal histomorphology was improved p<0.05 in all experimental groups by an increased villus height, VH : CD ration, colon crypt depth, and number of Ki-67+ epithelial cells. A higher number p<0.05 of goblet cells and their acidification were observed in group Pro, while the density of goblet cells was decreased by the herbs. Probiotics increased p<0.05 the number of intraepithelial lymphocytes (IELs), density of CD3+ cells in Peyer’s patches (PPs), and lamina propria (LP). In group H, a dual effect on the CD3+ cell distribution was observed. The herbs reduced p<0.05 the number of IELs and CD3+ in LP but increased the distribution of CD3+ cells in PPs. In the colon, herbs increased CD3+ cells in LP as well. It suggests that probiotics and herbs had influence on the intestinal histomorphology and the ability to modulate the mucosal immune system; however, the combination of probiotics and buckwheat bran was not so convincing, probably due to the inhibitory effect of the buckwheat bran on the probiotics used.

show abstract

Section: Discussionmentioning

confidence: 61%

Section: Veterinary Medicine Internationalmentioning

confidence: 99%

Effect of Probiotics and Herbal Products on Intestinal Histomorphological and Immunological Development in Piglets

Gāliņa

Ansonska

Valdovska

2020

Veterinary Medicine International

View full text Add to dashboard Cite

show abstract

“…These new intestinal epithelial cells replace intestinal villi epithelial cells loss caused by apoptosis, while allowing the piglet to adapt to intestinal adversity. Through this process, the digestive and absorption functions of intestinal epithelial cells are gradually improved (Wang et al, 2016;Papadopoulos et al, 2017). To some extent, the crypt depth of small intestinal villi re ects the production e ciency of intestinal epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

Feeding a Low-protein Maternal Diet Affects Qinghai Bamei Piglet Jejunal Microbiome-metabolome Response

Jin

Zhang

Chen

et al. 2021

Preprint

View full text Add to dashboard Cite

This experiment investigated the impacts of feeding a maternal low-CP concentration diet having iso-essential amino acids on new born suckling piglets intestinal microbial composition and metabolic profiles. The Bamei swine breed was selected due to high meat quality and flavor, but demonstrates slower growth rates which may be related to jejunal nutrient supply. Forty randomly selected purebred Bamei sows were divided into two groups and fed a low dietary CP (12%, LP) or a normal CP (14%, CON) diet, respectively, but formulated to contain similar (iso-) essential amino acid concentrations per current recommendations. At 21 days, 12 piglets were randomly selected from each treatment and euthanized with jejunum content samples collected. The 16S rRNA gene sequencing and mass spectrometry-based metabolomics profiling were combined as an integrated approach for evaluating the functional impact of maternal CP concentrations on piglet intestinal microbiome. Even though piglets demonstrated similar 0 to 21 d ADG among treatments, the jejunum relative weight, villus width, crypt depth and muscular thickness were increased (P < 0.05), while villus height, and villus height:crypt depth were reduced (P < 0.05) for the material LP compared to the maternal fed CON diet. Maternal CP concentrations can modify the intestinal microbial composition of Bamei suckling piglets. The relative abundances of the bacterial species Escherichia-Shigella, Actinobacillus, Clostridium_sensu_stricto_1, Veillonella, and Turicibacter were increased (P < 0.05) in the maternal LP fed diet compared with the maternal fed CON diet. Jejunal digesta metabolomics analysis indicated that several amino acids were metabolized (i.e. cys, met, tyr phe and trp), biosynthesized (arg phe, tyr, and trp), or degraded (lys) were enriched (P < 0.05) for the maternal fed LP compared with the maternal fed CON. Correlation analysis demonstrated that certain intestinal bacterial genera were highly related to the histomorphology and altered intestinal microbiota metabolites. In conclusion, maternal dietary CP concentrations in excess of protein and amino acid requirements not only altered suckling Bamei piglets histomorphology, microbial composition and function, but also modulated jejunum microbial metabolic profiles, which aids in understanding the beneficial effects when feeding a maternal LP diet on piglet intestinal health.

show abstract

“…IL-2 is a peptide immune regulator secreted by activated T lymphocytes [27]. It not only promotes T-cell proliferation and participates in T-cell apoptosis, but also exerts an immunosuppressive effect [17,28]. IL-6 is mainly produced by lymphocytes and monocytes that exhibit a wide range of biological and anti-inflammatory effects.…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Supplementation with Mulberry (Morus alba L.) Leaf Polysaccharides on Immune Parameters of Weanling Pigs

Zhao

Yang

et al. 2019

Animals

View full text Add to dashboard Cite

Simple Summary: The increasing overuse/misuse of restricted antibiotics in livestock and poultry production has raised a serious health concern. Thus, aiming to improve animals' health levels, researchers are redirecting their focus onto naturally occurring bioactive ingredients from plants; these compounds have become a potential substitute for antibiotics. Mulberry leaf polysaccharide (MLP) is an important bioactive component, which has notable potential for improving animal immunity. In this context, the present study was designed to investigate the MLPs' effect on animals' metabolisms and the immune parameters of weanling pigs.Abstract: In this study, the effect of dietary supplementation of mulberry leaf polysaccharides (MLPs) on the immune parameters-i.e., the immune organ weight, serum immunoglobulins, cytokines, nitric oxide (NO) production, and insulin-Like growth factor-1 (IGF1) mRNA expression-of weanling pigs as a model animal was investigated. A total of 120 healthy weanling pigs (aged 28 ± 2 d) with the same body weights were randomly divided into four groups: (1) Control treatment (CT), basal diet (BD), (2) MLP low-dose treatment (MLT), 0.6 g/kg MLP + BD, (3) MLP high-dose treatment (MHT), 1.2 g/kg MLP + BD, and (4) antibiotic treatment (AT), 0.15 g/kg chlortetracycline + BD. The results revealed that the thymus and spleen indices were significantly increased (P < 0.05) in both MLT and MHT groups in comparison with the CT group, while the serum levels of immunoglobulin G (IgG), interleukin (IL)-1β, IL-2, IL-8, and interferon (IFN-γ) in the MLT group and IL-2, IL-6, and IFN-γ in the MHT group were also considerably greater (P < 0.05) than the corresponding levels in the CT group. The serum contents of IgG, IL-1β, IL-2, and IL-8 in the MLT group and IL-2 and IL-6 in the MHT group were significantly increased in comparison with the corresponding contents in the AT group (P < 0.05). The transformation rate of lymphocytes in the MLT and MHT groups was higher compared to the CT and AT groups. However, a notable difference was found between the MLT group and the two control groups. The peripheral lymphocyte NO production in the MLT, MHT, and AT groups was significant relative to the CT group. The expression levels of IGF1 mRNA in the liver and muscle longissimus tissues of both the MLT and MHT groups showed significant improvement (P < 0.05) over those in the CT group. Moreover, the IGF1 mRNA expression in the muscle longissimus from the MLT group was significantly higher than in the AT group. In conclusion, the results suggest that incorporating MLPs into the diets of weanling pigs improves the animals' metabolisms and immune functions, and the effects of the MLT group were superior to those of both the MHT and AT groups.

show abstract

Dietary supplementation of encapsulated organic acids enhances performance and modulates immune regulation and morphology of jejunal mucosa in piglets

Cited by 13 publications

References 30 publications

Effect of Probiotics and Herbal Products on Intestinal Histomorphological and Immunological Development in Piglets

Effect of Probiotics and Herbal Products on Intestinal Histomorphological and Immunological Development in Piglets

Feeding a Low-protein Maternal Diet Affects Qinghai Bamei Piglet Jejunal Microbiome-metabolome Response

Effects of Dietary Supplementation with Mulberry (Morus alba L.) Leaf Polysaccharides on Immune Parameters of Weanling Pigs

Contact Info

Product

Resources

About