Dietary sodium butyrate and forskolin promote cell proliferation to resist Citrobacter rodentium infection by lysozyme upregulation

Wang, Jinping; Wu, Jianmin; Lin, Zishen; Ma, Ning; Men, Zhaoyue; Zhang, Chao; Ma, Xi; Zheng, Hongyu

doi:10.1016/j.jff.2023.105993

Journal of Functional Foods

2024

DOI: 10.1016/j.jff.2023.105993

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Dietary sodium butyrate and forskolin promote cell proliferation to resist Citrobacter rodentium infection by lysozyme upregulation

Jinping Wang,

Jianmin Wu,

Zishen Lin

et al.

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2024

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Microbiota-Derived Short-Chain Fatty Acids Boost Antitumoral Natural Killer Cell Activity

Pérez,

Buey,

Corral

et al. 2024

JCM

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Background: The intestinal microbiota can regulate numerous host functions, including the immune response. Through fermentation, the microbiota produces and releases microbial metabolites such as short-chain fatty acids (SCFAs), which can affect host homeostasis. There is growing evidence that the gut microbiome can have a major impact on cancer. Specific gut microbial composition and metabolites are associated with tumor status in the host. However, their effects on the antitumor response have scarcely been investigated. Natural killer (NK) cells play an important role in antitumor immunity due to their ability to directly identify and eliminate tumor cells. Methods: The aim of this study was to investigate the effects of SCFAs on antitumoral NK cell activity, using NK-92 cell line. Results: Here, we describe how SCFAs can boost antitumoral NK cell activity. The SCFAs induced the release of NK extracellular vesicles and reduced the secretion of the anti-inflammatory cytokine IL-10. The SCFAs also increased the cytotoxicity of the NK cells against multiple myeloma cells. Conclusions: Our results indicate, for the first time, the enormous potential of SCFAs in regulating antitumoral NK cell defense, where modulation of the SCFAs’ production could play a fundamental role in cancer immunotherapy.

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Microbiota-Derived Short-Chain Fatty Acids Boost Antitumoral Natural Killer Cell Activity

Pérez,

Buey,

Corral

et al. 2024

JCM

View full text Add to dashboard Cite

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Dietary sodium butyrate and forskolin promote cell proliferation to resist Citrobacter rodentium infection by lysozyme upregulation

Cited by 1 publication

References 46 publications

Microbiota-Derived Short-Chain Fatty Acids Boost Antitumoral Natural Killer Cell Activity

Microbiota-Derived Short-Chain Fatty Acids Boost Antitumoral Natural Killer Cell Activity

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