Dietary riboflavin deficiency decreases immunity and antioxidant capacity, and changes tight junction proteins and related signaling molecules mRNA expression in the gills of young grass carp (Ctenopharyngodon idella)

Chen, Liang; Feng, Lin; Jiang, Wei‐Dan; Jiang, Jun; Wu, Pei; Zhao, Juan; Kuang, Sheng‐Yao; Tang, Ling; Tang, Wu‐Neng; Zhang, Yong-An; Zhou, Xiao‐Qiu; Liu, Yang

doi:10.1016/j.fsi.2015.04.004

Cited by 89 publications

(81 citation statements)

References 84 publications

(116 reference statements)

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“…In fish, gill health status is largely dependent on its immune function [5] and physical barrier function [6]. Studies in our laboratory show that nutrients such as riboflavin [7] and folic acid [8] improve the gill immune function and physical barrier function of grass carp (Ctenopharyngodon idellus). Seifter et al [9] found that the content of riboflavin in the liver of rats decreased with a low protein diet.…”

Section: Introductionmentioning

confidence: 87%

“…To investigate the effects of diets containing graded levels of protein on the resistance of fish against gill rot, a scoring system was designed to evaluate the severity of fish gill rot that was similar to Taylor et al [3]. When sacrificed, fish gills were quickly removed, frozen in liquid nitrogen, and stored at À80 C for later analysis as described by Chen et al [7].…”

Section: Sample Collectionmentioning

confidence: 99%

“…The contents of reactive oxygen species (ROS), malondialdehyde (MDA), protein carbonyl (PC) and glutathione (GSH) in the gills were assayed as described by Feng et al [50]. The activities of catalase (CAT) and glutathione peroxidase (GPx) in the gills were determined according to Chen et al [7]. The total superoxide dismutase (SOD) and copper, zinc superoxide dismutase (CuZnSOD) activities in the gills were determined as described by Lu et al [51].…”

Section: Biochemical Analysismentioning

confidence: 99%

“…According to Chen et al [7], the gill immune function of grass carp is enhanced with an increase in LA and ACP activities and C3 content and the up-regulation of LEAP-2 and Hepcidin mRNA levels. In this study, compared with low or high levels of protein, at an optimal level of dietary protein, the activities of LA and ACP and contents of C3 and C4 increased, and the mRNA levels of LEAP-2A, LEAP-2B, Hepcidin and b-defensin were up-regulated in the gills of grass carp.…”

Section: Optimal Level Of Dietary Protein Increased Antibacterial Commentioning

confidence: 99%

“…Based on our understanding, inflammatory cytokines in fish are classified as pro-inflammatory cytokines (such as IL-1b, IL-8 and TNF-a) and anti-inflammatory cytokines (such as IL-6, IL-10 and TGF-b1), and down-regulated pro-inflammatory cytokines IL-1b, IL-8 and TNF-a mRNA levels and up-regulated anti-inflammatory cytokines IL-6, IL-10 and TGF-b1 mRNA levels could attenuate inflammation [7,62,63]. In the present study, compared with low or high levels of protein, the optimal levels of dietary protein led to the down-regulation of the pro-inflammatory cytokines IL-1b, IL-8, IFN-g2 and TNF-a mRNA levels and the up-regulation of the antiinflammatory cytokines IL-6, IL-11, TGF-b1 and TGF-b2 mRNA levels in the gills of grass carp.…”

Section: Optimal Level Of Dietary Protein Attenuated Inflammatory Resmentioning

confidence: 99%

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Effects of dietary protein levels on the disease resistance, immune function and physical barrier function in the gill of grass carp ( Ctenopharyngodon idella ) after challenged with Flavobacterium columnare

Feng

Jiang

et al. 2016

Fish & Shellfish Immunology

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Section: Introductionmentioning

confidence: 87%

Section: Sample Collectionmentioning

confidence: 99%

Section: Biochemical Analysismentioning

confidence: 99%

Section: Optimal Level Of Dietary Protein Increased Antibacterial Commentioning

confidence: 99%

Section: Optimal Level Of Dietary Protein Attenuated Inflammatory Resmentioning

confidence: 99%

See 3 more Smart Citations

Effects of dietary protein levels on the disease resistance, immune function and physical barrier function in the gill of grass carp ( Ctenopharyngodon idella ) after challenged with Flavobacterium columnare

Feng

Jiang

et al. 2016

Fish & Shellfish Immunology

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Reuniting overnutrition and undernutrition, macronutrients, and micronutrients

Kim

Basharat

Ramakrishnan

et al. 2018

Diabetes Metabolism Res

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Over-nutrition and its late consequences are a dominant theme in medicine today. In addition to the health hazards brought on by over-nutrition, the medical community has recently accumulated a roster of health benefits with obesity, grouped under "obesity paradox." Throughout the world and throughout history until the 20 century, under-nutrition was a dominant evolutionary force. Under-nutrition brings with it a mix of benefits and detriments that are opposite to and continuous with those of over-nutrition. This continuum yields J-shaped or U-shaped curves relating body mass index to mortality. The overweight have an elevated risk of dying in middle age of degenerative diseases while the underweight are at increased risk of premature death from infectious conditions. Micronutrient deficiencies, major concerns of nutritional science in the 20 century, are being neglected. This "hidden hunger" is now surprisingly prevalent in all weight groups, even among the overweight. Because micronutrient replacement is safe, inexpensive, and predictably effective, it is now an exceptionally attractive target for therapy across the spectrum of weight and age. Nutrition-related conditions worthy of special attention from caregivers include excess vitamin A, excess vitamin D, and deficiency of magnesium.

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Effect of Rhodopseudomonas sphaeroides–Treated Wastewater on Yield, Digestive Enzymes, Antioxidants, Nonspecific Immunity, and Intestinal Microbiota of Common Carp

Xie

et al. 2019

N American J Aquac

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The employment of traditional bait and medicament in freshwater aquaculture causes the frequent occurrence of environmental pollution and disease. Effluent collected after wastewater treatment with Rhodopseudomonas sphaeroides could be reutilized for microbial feed, medicament, and aquaculture water to culture Common Carp Cyprinus carpio. Therefore, a novel integrated system of wastewater treatment and the use of the effluent containing R. sphaeroides, which could improve yield, increase disease resistance, and enhance the quality of aquaculture water for Common Carp culture, was proposed and investigated. Common Carp can grow well in effluent containing R. sphaeroides. The survival rate, yield, and whole‐body composition of the fish raised in effluent containing R. sphaeroides were all increased compared with the control group. The biochemical (B vitamin) and other substances in the effluent with R. sphaeroides enhanced the activity of proteases, amylases, lipases, alkaline phosphatase, acid phosphatase, phagocytes, superoxide dismutase, and catalase by up‐regulating the expression of their associated genes. Theoretical analysis showed that biochemical molecules regulate the expression of these gene and enzyme activities by acting as a signal that stimulates the active center. Moreover, biochemicals present in R. sphaeroides enhanced the mTOR and NF‐kB signaling pathways and improved intestinal microbiota. Furthermore, R. sphaeroides inhibited Aeromonas hydrophila, increasing resistance against fish disease and promoting the growth of intestinal bacteria. Meanwhile, R. sphaeroides in the effluent also improved the aquaculture water quality. This technology would simultaneously save water in aquaculture, reduce water pollution and wastewater discharge, and increase the output and disease resistance of Common Carp.

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Dietary riboflavin deficiency decreases immunity and antioxidant capacity, and changes tight junction proteins and related signaling molecules mRNA expression in the gills of young grass carp (Ctenopharyngodon idella)

Cited by 89 publications

References 84 publications

Effects of dietary protein levels on the disease resistance, immune function and physical barrier function in the gill of grass carp ( Ctenopharyngodon idella ) after challenged with Flavobacterium columnare

Effects of dietary protein levels on the disease resistance, immune function and physical barrier function in the gill of grass carp ( Ctenopharyngodon idella ) after challenged with Flavobacterium columnare

Reuniting overnutrition and undernutrition, macronutrients, and micronutrients

Effect of Rhodopseudomonas sphaeroides–Treated Wastewater on Yield, Digestive Enzymes, Antioxidants, Nonspecific Immunity, and Intestinal Microbiota of Common Carp

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