Dietary Restriction Benefits Learning and Motor Performance of Aged Mice

Ingram, Donald K.; Weindruch, Richard; Spangler, Edward L.; Freeman, John R.; Walford, Roy L.

doi:10.1093/geronj/42.1.78

Cited by 319 publications

(162 citation statements)

References 0 publications

Supporting

Mentioning

156

Contrasting

Order By: Relevance

“…Average daily activity was higher for old male and female mice on CR when compared to controls (4,5). Rats as well as mice on CR and given access to a running wheel demonstrated higher levels of activity than controls (9,10,15). Everyother-day feeding differentially affected wheel running activity across the life span for male Wistar rats (9).…”

mentioning

confidence: 94%

“…As in the primate studies, activity is just one of many variables measured. Activity has been measured via wheel running, changes in locomotion, spontaneous activity, open field behavior, or load applied to a pressure transducer (6,19,13,15,39).…”

mentioning

confidence: 99%

“…Inasmuch as CR has been suggested as one possible intervention providing beneficial physiological protection against the effects of aging in rodents, (34,38) and that changes in activity are evident following induction of CR in rodents, (6,9,13,15,39) the question is whether long-term CR might influence overall activity and behavior in monkeys. To address this issue, the present analysis examined activity patterns in rhesus monkeys to characterize potential behavioral influences of long-term CR.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Activity Measures in Rhesus Monkeys on Long-Term Calorie Restriction

Weed

Lane

Roth

et al. 1997

Physiology & Behavior

113

View full text Add to dashboard Cite

. Activity measures in rhesus monkeys on long-term calorie restriction. PHYSIOL BEHAV 62(1) 97-103, 1997-Calorie restriction (CR), undernutrition without malnutrition, extends the mean and maximal lifespan of several ecologically diverse species. Rodents on CR demonstrate increased activity measured as spontaneous locomotion, wheel running, open field behavior or movement. Activity measures were recorded from 19 male rhesus monkeys (Macaca mulatta) as either controls (C) which were fed a nutritious diet to approximate ad libitum levels, or as experimentals (E) which were fed 30% less than age-and weight-matched controls. Within each diet group, some monkeys (n Å 10) began CR at 2.3 years of age (range 2.2-2.4 yrs, J Group) while another group (n Å 9) began CR at approximately 4.6 years of age (range 4-5.25, A group). Beginning about 6 years after initiation of the study, behavioral activity was measured via ultrasonic motion detectors and recorded on videotape. Diurnal and circadian activity was clearly discernible. Peaks in activity were associated with mealtime and colony husbandry. Compared to Group A, Group J monkeys exhibited higher overall activity as measured by sensors, and also significantly more circling. Compared to AC monkeys, group AE monkeys demonstrated higher rates of gross motor behavior, pacing, stereotypies and grooming. The increases in motor activity observed in one group of monkeys were consistent with results obtained from rodent studies of CR and aging. CR did not significantly inhibit or negatively influence the display of behavior of rhesus monkeys in the laboratory environment. We report here, for the first time, increases in activity due to CR in a model other than the rodent. ᭧ 1997 Elsevier Science Inc.

show abstract

mentioning

confidence: 94%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Activity Measures in Rhesus Monkeys on Long-Term Calorie Restriction

Weed

Lane

Roth

et al. 1997

Physiology & Behavior

113

View full text Add to dashboard Cite

show abstract

“…Clearly, the effects of DR on motoric function, assessed both within and across tasks, gave evidence that DR had beneficial effects on motor systems. Previous studies have similarly reported beneficial effects of DR on age-related impairments in motor performance of rodents [6,35]. Second, cognitive function demonstrated prominent age-related performance deficits.…”

Section: Discussionmentioning

confidence: 69%

Effects of chronic adult dietary restriction on spatial learning in the aged F344×BN hybrid F1 rat

Fitting¹,

Booze²,

Gilbert³

et al. 2008

Physiology & Behavior

View full text Add to dashboard Cite

Dietary restriction (DR) has been shown to increase life span and reduce disease incidence across a variety of species. Recent research suggests that chronic adult DR may also alter age-related cognitive decline. The purpose of this study was twofold: (1) to examine the potential deficits in spatial learning ability in the aged F344 X BN hybrid F1 rat with specific attention to the contributory effects of motoric impairments and (2) to determine the influence of chronic adult DR on any such impairments. The Morris water maze (MWM) task was employed with a 1.8 m diameter tank, 10 cm 2 escape platform, 28°C water, and an automated collapsing central starting platform. Spatial learning impairments in the aged rats were evident on all dependent measures during training and the probe test. Motoric function, as reflected in measures of strength and locomotion demonstrated profound age-related performance impairments that were attenuated by chronic adult DR. The present data also replicate previous reports, indicating that DR attenuates the age-related impairments of performance in the MWM as indexed by the latency measure in acquisition, but critically was dissociated from any DR effect on measures of preference and, more critically, accuracy in the probe test. Collectively, the most parsimonious interpretation of DR effects on MWM performance would appear to be the preservation of motoric, and not cognitive, function. KeywordsCognition; Motoric function; Morris water maze One of the more disconcerting age-related changes across a variety of species is a decline in learning and memory. Aging rodents have been shown to be a promising animal model for studying memory deficits. In particular, tasks of spatial memory have been employed [1][2][3][4][5][6][7][8] with clearly demonstrated deficits in aged rats as a model associated with aging humans [9][10][11]. Deficits that accompany the decline of spatial learning and memory in aged rats include a loss of visual acuity [12], thermoregulatory control [3], impairments in sensorimotor behavior [6,8,13], and the development of lesions and diseases [14]. These

show abstract

“…With regard to the central nervous system (CNS), recent studies have documented that a reduction of food intake in laboratory animals has beneficial effects on behavioural tests (8)(9)(10). DR attenuates the age-related loss of striatal dopamine receptors (11); suppresses age-related changes in dendritic spines (12); reduces the production of reactive oxygen species and it is able to counteract age-dependent changes in lipids of cortical membranes (13).…”

Section: Introductionmentioning

confidence: 99%

Dietary restriction modulates synaptic structural dynamics in the aging hippocampus

Bertoni–Freddari

Fattoretti

Caselli

et al. 1999

AGE

View full text Add to dashboard Cite

A computer-assisted morphometric study has been carried out on the synaptic ultrastructural features in the hippocampus of 14-month old (DR14) and 27-month old (DR27) dietary restricted (-50% lipids and -35% carbohydrates) rats. Age-matched controls were maintained on an ad libitum (AL) feeding schedule. Synaptic numeric density (Nv), surface density (Sv) and average area (S) were the parameters measured. In old AL vs. adult AL animals, Nv decreased to a not significant extent, while S increased and Sv decreased significantly. In DR14 rats vs. AL littermates Nv increased significantly, but S and Sv were unchanged. DR27 rats vs. agematched AL controls showed a significant increase of Nv and Sv while S was significantly decreased. Comparing DR14 vs. DR27, no significant difference due to age was documented. Both in DR14 and in DR27 groups the percent distribution of S showed a marked increase of smaller contact zones. Despite reporting on discrete aspects of synaptic ultrastructure, Nv and S are supported to be in an inverse relationship which aims at maintaining Sv constant. Thus, these three ultrastructural parameters when taken together per experimental group, appear to provide information on synaptic morphological rearrangements. In this context, the percent increase of smaller synapses in DR animals is consistent with the idea of a marked remodelling process. Considering previous data from the same groups of rats reporting significant changes in neuronal membrane lipid composition and fluidity, we interpret our findings to account for a positive modulation of dietary restriction on the synaptic structural dynamics.

show abstract

Dietary Restriction Benefits Learning and Motor Performance of Aged Mice

Cited by 319 publications

References 0 publications

Activity Measures in Rhesus Monkeys on Long-Term Calorie Restriction

Activity Measures in Rhesus Monkeys on Long-Term Calorie Restriction

Effects of chronic adult dietary restriction on spatial learning in the aged F344×BN hybrid F1 rat

Dietary restriction modulates synaptic structural dynamics in the aging hippocampus

Contact Info

Product

Resources

About