Dietary rapeseed/canola-oil supplementation reduces serum lipids and liver enzymes and alters postprandial inflammatory responses in adipose tissue compared to olive-oil supplementation in obese men

Kruse, Michael; Loeffelholz, Christian von; Hoffmann, Daniela; Pohlmann, Antje; Seltmann, Anne‐Cathrin; Osterhoff, Martin; Hornemann, Silke; Pivovarova, O; Rohn, Sascha; Jahreis, Gerhard; Pfeiffer, Andreas F. H.

doi:10.1002/mnfr.201400446

Cited by 71 publications

(58 citation statements)

References 52 publications

(61 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Consistent with these ndings, previous studies have reported no signi cant effect of the intake of re ned OO (60 g/day) on plasma TG, LDL-C, or HDL-C levels in mildly hypercholesterolemic subjects who were not on lipid-lowering medications [46] or in stable coronary artery disease patients (50 mL/day) [47]. However, some previous studies have reported the bene cial effects of CO on plasma lipids [48][49][50][51]. Nevertheless, it should be noted that the study population in these studies were healthy people or those with cardiovascular risk factors who were not taking lipid-lowering agents.…”

Section: Discussionsupporting

confidence: 53%

Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A2 and inflammatory cytokines in patients referred for coronary angiography

Khandouzi

Zahedmehr

Nasrollahzadeh

2020

Preprint

View full text Add to dashboard Cite

Background: The potential cardioprotective benefits of olive oil (OO) and canola oil (CO) consumption have been shown in some studies. The present study compared the effects of CO and OO on plasma lipids, some inflammatory cytokines, and lipoprotein-associated phospholipase A2 (Lp-PLA2) mass and activity in patients undergoing coronary angiography. Methods: The current randomized, controlled, parallel-arm, clinical trial involved 48 patients (44 men and 4 women, aged 57.63 ± 6.34 years) with at least one classic cardiovascular risk factor (hypertension, dyslipidemia, or diabetes) who referred for coronary angiography. Patients were randomly divided into two groups and received 25 mL/day refined olive oil (n=24) or canola oil (n=24) for 6 weeks. Plasma lipids, some selected inflammatory markers, and Lp-PLA2 levels were measured at baseline and after the intervention.Results: CO consumption produced a significant reduction in plasma Lp-PLA2 mass (-0.97 ± 1.84 vs. 0.34 ± 1.57 ng/mL, p = 0.008 for CO and OO, respectively), whereas the mean changes in interleukine-6 concentration were significantly lower after OO consumption compared with CO (-9.46 ± 9.46 vs. -0.90 ± 6.80 pg/mL, p = 0.008 for OO and CO, respectively). After 6 weeks of intervention, no significant changes were observed in plasma Lp-PLA2 activity, complement C3, C4, or lipid profiles in the two intervention groups.Conclusions: Comparing the two vegetable oils in subjects with cardiovascular risk factors showed that the consumption of olive oil is more effective in reducing the level of inflammatory cytokine interleukine-6, whereas canola oil was more effective in lowering Lp-PLA2 levels; however, this finding should be interpreted with caution, because Lp-PLA2 activity did not change significantly.Trial registration: IRCT20160702028742N5 at www.irct.ir (04/19/2019)

show abstract

Section: Discussionsupporting

confidence: 53%

Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A2 and inflammatory cytokines in patients referred for coronary angiography

Khandouzi

Zahedmehr

Nasrollahzadeh

2020

Preprint

View full text Add to dashboard Cite

show abstract

“…The multivariable-adjusted hazard ratios were 0.70 (95 % confidence interval, 0.54 to 0.92) and 0.72 (95 % confidence interval, 0.54 to 0.96) for the group assigned to a Mediterranean diet with extra-virgin olive oil versus the control group (109 events). Olive oil has been shown to reduce hepatic steatosis and to improve markers of systemic inflammation [87][88][89]. Similar to non-transplant patients with metabolic syndrome, consideration should be given to recommending a Mediterranean diet, including ∼60 mL/day of olive oil to liver transplant recipients.…”

Section: Non-pharmacological Therapymentioning

confidence: 98%

An Update of Liver Transplantation for Nonalcoholic Steatohepatitis

Thomason

Charlton

2015

Curr Hepatology Rep

View full text Add to dashboard Cite

Nonalcoholic steatohepatitis (NASH), obesity, and the metabolic syndrome are highly prevalent before and after liver transplantation, with NASH currently the second most common indication. This review considers established and new aspects of liver transplantation for NASH. NASH is one of many sequelae of obesity and most frequently occurs on a background of the metabolic syndrome. While recurrence of steatosis is common, recurrence of NASH with advanced stages of fibrosis is unusual, with graft loss due to recurrence of NASH cirrhosis occurring with a frequency of less than 5 %. In contrast, the components of the metabolic syndrome, which are important predictors of posttransplant outcomes, are nearly ubiquitous following liver transplantation and are exacerbated by factors such as immunosuppression. As many aspects of the metabolic syndrome are modifiable, screening for and treating complications of obesity and minimization of immunosuppression are cornerstones of optimizing outcomes for transplant recipients with NASH. The optimal approach to immunosuppression, the role of bariatric surgery, and nutritional and pharmacotherapy of NASH in liver transplant recipients are evolving rapidly. Overall, a minimalist approach to immunosuppression is advised.

show abstract

“…Als wesentliche Fettquelle wird Rapsöl verwendet. Neuere Untersuchungen legen nahe, dass Rapsöl eine gleichwertige oder möglicherweise bessere Alternative zu Olivenöl darstellt [46]. In gewisser Weise stellt diese Kostform eine länderspezifische Adaptation der mediterranen Ernährung dar.…”

Section: Nordic-dietländerspezifische Adaption Der Mediterranen Kostunclassified

Ernährung in der Prävention und Therapie der koronaren Herzkrankheit

Zyriax¹,

Windler²

2018

Aktuel Ernahrungsmed

View full text Add to dashboard Cite

Diet and lifestyle have an important impact on the development of cardiovascular risk factors, the manifestation of coronary heart disease, and the prognosis after a cardiovascular event. Even in the presence of strong genetic predisposition patients benefit from a healthy lifestyle with respect to coronary heart disease. Much of the effectiveness of lifestyle interventions is supposedly due to their broad influence on all major risk factors as there are overweight, central obesity, lipid disorders, hypertension, and diabetes mellitus type 2, but also due to independent mechanisms. A Mediterranean diet has been repeatedly shown to reduce cardiovascular events by exchange of several nutrients among others preferring olive oil or nuts, even without measurable impact on conventional risk factors. A diet rich in fruit, vegetables and low-fat milk products and limited in salt and calories if appropriate is considered evidence-based for reducing elevated blood pressure and prevention of coronary heart disease. In terms of insulin resistance and prevention of type 2 diabetes the multimodal interventions of the diabetes prevention studies have set the gold standard. Strictly avoiding nutrients rich in those fatty acids (lauristic, myristic, palmitic acid) that increase cholesterol synthesis and reduce hepatic LDL-uptake have proven effective for lowering LDL-cholesterol. Even in clinically overt coronary heart disease, diet, physical activity, and stress management can induce regression of coronary stenoses and reduce angina pectoris. Diet and lifestyle may be employed as a sole preventative measure, but also combined with medication. Recommendations need not only consider the individual risk profile, but also the personal preferences to ensure adequate adherence.

show abstract

Dietary rapeseed/canola-oil supplementation reduces serum lipids and liver enzymes and alters postprandial inflammatory responses in adipose tissue compared to olive-oil supplementation in obese men

Abstract: This demonstrates that consuming RA for 4 wk improves serum lipids, liver enzymes, and basal inflammation in s. c. adipose tissue, but it mediates an acute pro-inflammatory response in adipose tissue upon consuming a meal.

Cited by 71 publications

References 52 publications

Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A2 and inflammatory cytokines in patients referred for coronary angiography

Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A2 and inflammatory cytokines in patients referred for coronary angiography

An Update of Liver Transplantation for Nonalcoholic Steatohepatitis

Ernährung in der Prävention und Therapie der koronaren Herzkrankheit

Contact Info

Product

Resources

About