Dietary polyphenols modulate intestinal barrier defects and inflammation in a murine model of colitis

Quercetin increases claudin-4 expression through multiple transcription factors in intestinal Caco-2 cells

“…The aglycone is then conjugated in the intestinal epithelium and released into the blood. We previously reported that feeding quercetin aglycone ameliorated colonic barrier defects and inflammation in a model of colitic mice (Shigeshiro, Tanabe, & Suzuki, 2013). Furthermore, our studies showed that quercetin increased barrier integrity in intestinal Caco-2 cells, in part through claudin-4 expression (Suzuki & Hara, 2009).…”

“…Clinical observations also revealed that claudin-4 expression is reduced in the TJs in colonic biopsy specimens from IBD patients (Prasad et al, 2005). We have reported that feeding quercetin ameliorates colonic inflammation and barrier defects in a model of colitic mice (Shigeshiro et al, 2013). This evidence suggests that the protection and promotion of the intestinal barrier by food factors, such as quercetin, could afford therapeutic and preventive approaches to diseases associated with intestinal barrier defects.…”

Impact of deoxynivalenol and kaempferol on expression of tight junction proteins at different stages of Caco-2 cell proliferation and differentiation

“…19 The protective effects of quercetin, naringenin, berberine and curcumin on the integrity of tight junction have all been reported. [20][21][22][23] Gut microbiota fermented product of butyrate also enhances the intestinal barrier function through facilitating the assembly of TJ proteins. 24 Thus, bioactive compounds might be an effective strategy to combat the toxicity of DON for improved barrier functions of intestinal epithelium to protect the body against luminal bacteria and toxic materials.…”

Purple Potato Extract Promotes Intestinal Epithelial Differentiation and Barrier Function by Activating AMP‐Activated Protein Kinase

“…Accumulating evidence supports the beneficial effects of dietary polyphenols in preventing leaky gut . Dietary intake of polyphenol‐rich food, such as green tea, grapes, and berries, strengthens intestinal barrier integrity and the formation of tight junctions in an energy‐dependent manner .…”

“…[8] Accumulating evidence supports the beneficial effects of dietary polyphenols in preventing leaky gut. [9,10] Dietary intake of polyphenol-rich food, such as green tea, grapes, and berries, strengthens intestinal barrier integrity and the formation of tight junctions [11] in an energy-dependent manner. [12] Furthermore, polyphenol extracts are known to activate adenosine monophosphate-activated protein kinase (AMPK), [9] an energy sensor that regulates tight junctions and epithelial permeability.…”