Dietary Piperine is Transferred into the Milk of Nursing Mothers

́Diaye, Katharina N; Debong, Marcel W.; Behr, Jürgen; Dirndorfer, Sebastian; Duggan, Tara; Beusch, Anja; Schlagbauer, Verena; Dawid, Corinna; Loos, Helene M.; Buettner, Andrea; Lang, Roman; Hofmann, Thomas

doi:10.1002/mnfr.202100508

Cited by 5 publications

(2 citation statements)

References 38 publications

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“…As consumption of balanced meals and proper nutrition is crucial for successful postpartum recovery and breastfeeding, piperine’s positive effect on the digestive tract, as well as the antioxidative effect may have helped the mothers to maintain good health and nutritional status to sustain optimal breastfeeding ( Mistry & Williams, 2011 ; Goyal, 2017 ; Haq, et al, 2021 ). Nevertheless, as lactating mothers’ consumption of P. nigrum results in the transfer of piperine into the breastmilk, its potential effect on newborns warrants further investigation ( N' Diaye et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Use of Herbal Medicines Among Breastfeeding Mothers in Tanzania: A Cross-Sectional Study

Millinga

Hwang

et al. 2022

Front. Pharmacol.

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Background: There are limited data on the use of herbal medicines (HM) among breastfeeding mothers, despite the fact that knowledge of the possible benefits or harms of HM use has a direct relationship with the health of infants, especially in resource-limited countries. The study aims to determine the prevalence and factors associated with HM use among breastfeeding mothers in Tanzania.Methods: The study followed a cross-sectional design using a structured survey questionnaire. Survey participants were recruited from the reproductive and child health clinic at Uhuru health center in Morogoro, Tanzania. The survey instrument comprised of 34 questions, including demographic information, the pattern of HM use during breastfeeding, and women’s perceptions of HM. Chi-square test and logistic regression were used for data analysis using SPSS ver. 24.0.Results: The majority of the respondents (53.8%) used HM during breastfeeding. The most commonly used HM was black pepper (Piper nigrum L.; 80.0%), followed by pumpkin seeds (Cucurbita pepo L.; 18.0%). About one-third (27.5%) of HM users discussed their use with their healthcare providers. In addition, higher education levels and low breastmilk supply were identified as potential predictors of HM use.Conclusion: The practice of HM use among breastfeeding mothers in Tanzania is popular to ease breastfeeding difficulties. However, the issue of the safety or effectiveness of HM is still an unknown agenda. This awakens the need to evaluate HM’s safety, efficacy, and quality through pharmacological studies for scientific evidence. Lastly, a clinical guideline should be developed in healthcare settings to promote open dialogues between the healthcare providers and mothers to ensure the safe use of HM.

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Section: Discussionmentioning

confidence: 99%

Use of Herbal Medicines Among Breastfeeding Mothers in Tanzania: A Cross-Sectional Study

Millinga

Hwang

et al. 2022

Front. Pharmacol.

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“…15) Auch das scharf schmeckende Piperin geht von der Nahrung in die Muttermilch über (Abbildung oben). 16)…”

Section: Aromaanalytik Und Chemokommunikationunclassified

Trendbericht Lebensmittelchemie 2023

Loos¹

2023

Nachr Chem

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Hören, sehen, riechen, schmecken, fühlen – mit unseren Sinnen nehmen wir Informationen über unsere Umwelt auf. So können wir die Qualität von Lebensmitteln einschätzen, aber auch – teils ohne es zu merken – mit unseren Mitmenschen kommunizieren. Gerade die Forschung zur chemischen Kommunikation beim Menschen erlebt nach Jahrzehnten einen erneuten Aufschwung in der Aroma‐ und Geruchsforschung, einem Teilbereich der Lebensmittelchemie.

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Linalool, 1,8‐Cineole, and Eugenol Transfer from a Curry Dish into Human Urine

Debong,

N'Diaye,

Schöberl

et al. 2023

Molecular Nutrition Food Res

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ScopeFor most substances, there are several routes of excretion from the human body. This study focuses on urinary excretion of dietary odorants and compares the results with previously obtained results on excretion into milk.Methods and resultsLactating mothers (n = 18) are given a standardized curry dish and donate urine samples before and after the intervention. The odorants 1,8‐cineole, linalool, cuminaldehyde, cinnamaldehyde, 4‐hydroxy‐2,5‐dimethyl‐3(2H)‐furanone, sotolone, eugenol, vanillin, and γ‐nonalactone are quantitatively analyzed. A significant transition of up to 6 µg g−1 creatinine into urine is observed for linalool, 1,8‐cineole, and eugenol. Maximum concentrations are reached 1.5 h after the intervention for 1,8‐cineole and eugenol as well as 2.5 h after the intervention for linalool. Comparison with previous results reveals that the excretion pattern of odorants into urine is divergent from the one into milk. In a second intervention study (n = 6), excretion of phase II metabolites into urine is studied using β‐glucuronidase treatment. Linalool and eugenol concentrations are 23 and 77 times higher after treatment than before treatment with β‐glucuronidase, respectively.ConclusionThe study demonstrates transition of linalool, 1,8‐cineole, and eugenol from the diet into urine and excretion of glucuronides in the case of linalool, eugenol, and vanillin.

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Dietary Piperine is Transferred into the Milk of Nursing Mothers

Cited by 5 publications

References 38 publications

Use of Herbal Medicines Among Breastfeeding Mothers in Tanzania: A Cross-Sectional Study

Use of Herbal Medicines Among Breastfeeding Mothers in Tanzania: A Cross-Sectional Study

Trendbericht Lebensmittelchemie 2023

Linalool, 1,8‐Cineole, and Eugenol Transfer from a Curry Dish into Human Urine

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