Dietary nitrate – An unrecognized nutrient?

Ashworth, A.; Bailey, S. J.; Hayward, Giles M.; DiMenna, Fred J.; Vanhatalo, Aila; Jones, Andrew M.

doi:10.1016/j.clnesp.2015.03.057

Cited by 2 publications

(2 citation statements)

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“…Also, it should be noted that some patients suffering from cardiovascular disorders, obesity and type 2 diabetes may have a lower response to dietary nitrate given the impaired NO metabolism associated with these conditions. Some negative studies reported significant correlations with baseline systolic blood pressure, inferring that healthy participants with the highest baseline experienced greatest reductions ( 79 , 80 ) . The conclusion that can be drawn from studies reporting non-significant changes to blood pressure is that the overall understanding of the efficacy of nitrate supplementation is still unclear, especially in patients with pre-existing clinical conditions.…”

Section: Is Dietary Nitrate a New Nutrient?mentioning

confidence: 99%

Dietary nitrate and blood pressure: evolution of a new nutrient?

Ashworth

Bescos

2017

Nutr. Res. Rev.

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Dietary nitrate is mainly obtained from vegetables, especially green leafy vegetables and beetroot. As a result of early research, dietary nitrate is currently viewed as a contaminant linked to increased risks of stomach cancer and methaemoglobinaemia. Consequently, nitrate levels are restricted in certain vegetables and in water supplies to ensure exposure levels remain below an acceptable daily intake of 3·7 mg/kg per d. The average nitrate intake in the UK is approximately 70 mg/d, although some population groups, such as vegetarians, may consume three times that amount. However, recent studies in the last decade suggest that dietary nitrate can significantly reduce systolic blood pressure via the nitrate-nitrite-NO pathway. A small, downward shift in systolic blood pressure across the population could significantly reduce the incidence of hypertension and mortality from CVD such as stroke. Interestingly, vegetarians tend to have lower levels of blood pressure than omnivores and epidemiological studies suggest that vegetarians have lower risks of CVD. Recent evidence is mainly focused on the acute effects of dietary nitrate supplementation and there is a lack of data looking at the chronic effects of high nitrate consumption in humans. Nevertheless, due to potential health benefits, some authors are recommending that nitrate should be considered as a nutrient necessary for health, rather than as a contaminant which needs to be restricted. This review will discuss the emerging role of dietary nitrate in the control of blood pressure and whether there is sufficient evidence to state that nitrate is a 'new' nutrient.

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Section: Is Dietary Nitrate a New Nutrient?mentioning

confidence: 99%

Dietary nitrate and blood pressure: evolution of a new nutrient?

Ashworth

Bescos

2017

Nutr. Res. Rev.

View full text Add to dashboard Buy / Rent full text

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“…Over the past decade, many investigations have demonstrated the efficacy of dietary nitrate (NO 3 Ϫ ) supplementation in the treatment of several prevalent diseases related to loss of NO bioavailability; accordingly, it has been hailed as an "unrecognized nutrient" (1,42). Specifically, investigations performed in healthy and patient populations demonstrate that dietary NO 3…”

Section: Introductionmentioning

confidence: 99%

The effect of dietary nitrate supplementation on the speed-duration relationship in mice with sickle cell disease

Ferguson

Redinius

Harral

et al. 2020

Journal of Applied Physiology

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Sickle cell disease (SCD) causes exercise intolerance likely due to impaired skeletal muscle function and low nitric oxide (NO) bioavailability. Dietary nitrate improves hemodynamic and metabolic control during exercise in humans and animals. The purpose of this investigation was to assess the impact of nitrate supplementation on exercise capacity as measured by the running speed to exercise duration relationship (critical speed (CS)) in mice with SCD. We tested the hypothesis that nitrate supplementation via beetroot juice (BR) would attenuate the exercise intolerance observed in mice with SCD. Ten wild-type (WT) and 18 Berkley sickle-cell mice (BERK) received water (WT: n=10, BERK: n=10) or nitrate-rich BR (BERK+BR: n=8, nitrate dose 1 mmol/kg/day) for five days. Following the supplementation period, all mice performed 3-5 constant-speed treadmill tests that resulted in exhaustion within 1.5 to 20 min. Time to exhaustion vs. treadmill speed was fit to a hyperbolic model to determine CS. CS was significantly lower in BERK vs. WT and BERK+BR with no significant difference between WT and BERK+BR (WT: 36.6 ± 1.6, BERK: 23.8 ± 1.5, BERK+BR: 31.1 ± 2.1 m/min, p<0.05). Exercise tolerance, measured via CS, was significantly lower in BERK mice relative to WT. However, BERK mice receiving 5 days of nitrate supplementation exhibited no difference in exercise tolerance when compared to WT. These results support the potential utility of a dietary nitrate intervention to improve functionality in SCD patients.

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Dietary nitrate – An unrecognized nutrient?

Cited by 2 publications

References 0 publications

Dietary nitrate and blood pressure: evolution of a new nutrient?

Dietary nitrate and blood pressure: evolution of a new nutrient?

The effect of dietary nitrate supplementation on the speed-duration relationship in mice with sickle cell disease

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