Dietary Medium- and Long-chain Triacylglycerols Accelerate Diet-Induced Thermogenesis in Humans

Abstract

This study investigated the effects of a liquid meal containing medium-and long-chain triacylglycerols (MLCT) on diet-induced thermogenesis (DIT) and was conducted in double-blind crossover manner. Twenty subjects participated in this examination. The subjects consumed the liquid meal, which was made with 14g of canola oil (LCT, long-chain triacylglycerols) or MLCT containing about 12% medium-chain fatty acids (MCFA). Oxygen consumption and carbon dioxide production were measured by indirect calorimetry. Resting energy expenditure (REE) was determined based on there parameters, applying the equation of Weir. Increase in DIT after ingesting the liquid meal with MLCT during 6h was significantly greater than with LCT (P<0.05). The results suggest that the substitution of MLCT for cooking oil is useful to control body weigh and fat in subjects.

Consumption of medium- and long-chain triacylglycerols decreases body fat and blood triglyceride in Chinese hypertriglyceridemic subjects

“…Kasai et al (2003b) reported that subjects consumed the test bread, made with 14 g (about 6% of total energy) of MLCT containing 1.7 g MCFAs, and had a significant reduction in body weight and body fat accumulation. Similar researches were often seen recently (Nosaka et al, 2003;Ogawa et al, 2007). In our research, subjects were asked to consume 25-30 g MLCT oil daily, which contains about 13% MCFAs ( Table 2).…”

“…Reduction of body weight and body fat weight by consumption of MCT relative to LCT is attributed to increased energy expenditure and fat oxidation, respectively (St-Onge et al, 2003a, b;Ogawa et al, 2007), but the energy expenditure and fat oxidation were to a lower extent in individuals of greater body weight compared with individuals of lower body weight (St-Onge and Jones, 2003). This implies that subjects with greater BMI or body weight might not respond better to MCT.…”

“…Recently, a new oil composed of medium-and long-chain triacylglycerol (MLCT) in the same glycerol molecule produced by transesterification technique (Ogawa et al, 2007) was permitted to use as cooking oil (by Japanese Ministry of Health, Labour and Welfare; Aoyama et al, 2007). The purpose of this trial was to investigate whether the MLCT oil could reduce blood TG in hypertriglyceridemic humans undergoing a free living pattern.…”

Triglyceride with Medium-Chain Fatty Acids Increases the Activity and Expression of Hormone-Sensitive Lipase in White Adipose Tissue of C57BL/6J Mice

“…4) Dietinduced thermogenesis is accelerated as a result. 5) Many investigations during the past few years have reported that the intake of MCFA or MCT resulted in less body weight gain and body fat mass in animals and humans. [6][7][8][9] Our previous studies on humans have suggested that dietary oil containing MCFA could reduce in hypertriglyceridemic subjects the body weight, body mass index (BMI), body fat mass, waist circumference (WC), hip circumference (HC) and waist-hip ratio when compared to oil containing LCFA, and that these effects were much better in subjects who were male, overweight and less than 60 years old.…”

Chinese Hypertriglycerideamic Subjects of Different Ages Responded Differently to Consuming Oil with Medium- and Long-Chain Fatty Acids

“…6) Recently, another kind of fatty acids, MCFAs have become more attractive because they have been found to be effective in the reduction of body weight and body fat weight in both humans, and animals. [7][8][9][10][11][12][13][14][15][16] As for effects of MCFAs on blood TG in humans, there are contradictory reports. Some investigations have found negative effects of MCFAs on blood TG.…”