Dietary Magnesium Intake Affects the Association Between Serum Vitamin D and Type 2 Diabetes: A Cross-Sectional Study

Huang, Wei-Chao; Ma, Xiaoman; Liang, Hualiang; Li, Haojia; Chen, Jiayu; Fang, Liujia; Zhang, Zhenhui

doi:10.3389/fnut.2021.763076

Cited by 18 publications

(21 citation statements)

References 33 publications

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“…We simultaneously showed the results of the unadjusted, minimally adjusted (age, gender), multiply adjusted (age, gender, lactate, SOFA score, systolic heart failure, emergency admission, operative admission, and AKI within 12 h) and fully adjusted (for details of all the covariates, see Table 1) analyses. We also performed tests for the linear trends by entering the median value of each category of sCD73 as a continuous variable in the models (23).…”

Section: Discussionmentioning

confidence: 99%

The relationship between soluble CD73 and the incidence of septic shock in severe sepsis patients: a cross-sectional analysis of data from a prospective FINNAKI study

Gao¹,

Chen²,

Kong³

et al. 2022

Ann Transl Med

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Background: Sepsis is a leading cause of mortality worldwide. Septic shock is a subtype of sepsis in which the underlying cardiovascular and cellular/metabolic disorders are profound enough to increase mortality significantly. We sought to investigate the association between soluble cluster of differentiation-73 (sCD73) and the incidence of septic shock in severe sepsis patients.Methods: This cross-sectional study included 588 Finnish patients with severe sepsis or septic shock from the Finnish Acute Kidney Injury (FINNAKI) study. The primary exposure of interest was baseline level of sCD73. The outcome was the incidence of septic shock. Multivariable logistic regression analyses were performed to assess the independent association between sCD73 and the incidence of septic shock. Results:The average age of 588 participants was 62±16 years, and 65.14% of the patients were male.The average sCD73 was 5.11 (interquartile range, 3.30, 8.25) ng/mL. The incidence of sepsis shock was 429 (72.96%). In the multivariate logistic regression model, sCD73 was negatively associated with septic shock. After multiple adjustments (for age, gender, lactate, the Sequential Organ Failure Assessment score, systolic heart failure, emergency admission, operative admission, and acute kidney injury within 12 h), a 1 ng/mL increment in sCD73 was associated with a 5% lower incidence of septic shock [odds ratio (OR) =0.95; 95% confidence interval (CI): 0.92, 0.98; P<0.001].Conclusions: We found that sCD73 was negatively correlated with septic shock. Higher sCD73 was associated with a lower incidence of septic shock.

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Section: Discussionmentioning

confidence: 99%

The relationship between soluble CD73 and the incidence of septic shock in severe sepsis patients: a cross-sectional analysis of data from a prospective FINNAKI study

Gao¹,

Chen²,

Kong³

et al. 2022

Ann Transl Med

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“…A cross-sectional study by Huang et al among the American population in 2021 demonstrated that Magnesium is an important cofactor for the double hydroxylation of Vit D, and that the activity of Vit D binding receptors is a Magnesium-dependent process. Accordingly, high Magnesium intake can promote the activation of Vit D and increase the transfer of Vit D to target tissues ( 8 ). To sum up, Magnesium supplementation may enhance the activity of Vit D, thereby increasing its protective function on pancreatic β-cells.…”

Section: Discussionmentioning

confidence: 99%

“…This study was designed as a cross-sectional study, where the target independent variable was the serum Vit D level at the time of participant testing, and the dependent variable was whether the participants were diagnosed with pancreatic β-cell dysfunction. Depending on the median daily intake of Magnesium, the participants were divided into the low intake group (Magnesium intake <267 Magnesium/d) ( n = 2,436) and the high intake group (Magnesium intake ≥ 267 Magnesium+/d) ( n = 2,442) ( 8 ).…”

Section: Methodsmentioning

confidence: 99%

“…Can Magnesium, as an activator of Vit D and a regulator of pancreatic β-cell functionality, affect the association between serums Vit D levels and pancreatic β-cells? There have been few similar reports in the existing literature ( 8 , 31 , 32 ). Hence, clinical research concerning the effect of Magnesium intake on the association of serums Vit D levels with the risk of pancreatic β-cell impairment is necessary.…”

Section: Introductionmentioning

confidence: 99%

“…Vitamin D (Vit D), as a kind of lipid-soluble vitamins, has vitamins D3 and D2 as major components ( 7 ). According to some research findings, Vit D can increase the blood calcium and phosphorus while regulating the bone metabolism in coordination with parathyroid hormones, exhibiting preferable performance in enhancing immunity, as well as in preventing cancer, cardiovascular and metabolic diseases ( 8 – 12 ). However, its association with pancreatic β-cell functionality remains controversial.…”

Section: Introductionmentioning

confidence: 99%

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Dietary Magnesium Intake Affects the Vitamin D Effects on HOMA-β and Risk of Pancreatic β-Cell Dysfunction: A Cross-Sectional Study

et al. 2022

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BackgroundSome studies have shown that, the circulating vitamin D (Vit D) concentration in the body exerts a crucial role in regulating the pancreatic β-cell function. Meanwhile, the role of magnesium is important in the synthesis of Vit D, since it is an essential element for activating Vit D. Nevertheless, there remains insufficient studies concerning whether dietary Magnesium intake influences the association between Vit D and risk of pancreatic β-cell dysfunction. Hence, this cross-sectional study aimed to assess the effect of Magnesium intake alterations on the association between serum Vit D levels and the risk of pancreatic β-cell dysfunction.MethodsThis large-scale cross-sectional study involves four cycles of National Health and Nutrition Examination Survey (NHANES) (2007–2014), with totally 4,878 participants. Groups were divided depending on the median daily intake of Magnesium, namely, the low intake group (Magnesium intake <267 Magnesium/d) and the high intake group (Magnesium intake ≥ 267 Magnesium/d). By constructing multiple multivariate linear and logistics regression models, the associations between serum Vit D levels and HOMA-β, as well as between serum Vit D levels and the risk of pancreatic β-cell dysfunction were explored at different Magnesium intakes.ResultsIn this cross-sectional study, the serum Vit D level is independently correlated with the HOMA-β index [β: 0.65 (0.40–0.90)] and the risk of pancreatic β-cell dysfunction [OR: 0.95 (0.92–0.98)]. Moreover, such correlations are affected by different dietary Magnesium intakes (P for interaction < 0.001).ConclusionAccording to the results of this study, the dietary Magnesium intake influences the associations of serum Vit D levels with HOMA-β index and pancreatic β-cell dysfunction. Besides, the finding requires validation through more RCT or cohort studies.

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Association between dietary niacin intake and cognitive function in the elderly: Evidence from NHANES 2011–2014

Shen

Yang

Liu

et al. 2023

Food Science & Nutrition

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Recent studies have shown an inconsistent association between dietary niacin and cognitive function. And this remains unclear in the American outpatient population.The aim of this study was to assess whether there is an association between dietary niacin and cognitive performance in an older American population aged ≥60 years. A total of 2523 participants from the National Health and Nutrition Examination Survey (NHANES) 2011-2014 were enrolled. Cognitive function was assessed by the CERAD Word Learning (CERAD-WL) test, the CERAD Delayed Recall (CERAD-DR) test, the Animal Fluency test (AFT), and the Digit Symbol Substitution test (DSST). Cognitive impairment that meets one of the four scoring conditions listed above is defined as low cognitive function. Dietary niacin intake was obtained from 2 days of a 24-h recall questionnaire. Based on the quartiles of dietary niacin intake, they were divided into four groups: Q1 (<15.51 mg), Q2 (15.51-20.68 mg), Q3 (20.69-26.90 mg), and Q4(>26.91 mg). The stability of the results was assessed using multifactorial logistic regression, restricted cubic spline (RCS) models, and sensitivity stratified analysis. More than half of the participants had cognitive impairment (52.52%). In the fully adjusted model, niacin was associated with a significantly reduced risk of cognitive impairment in Q3 and Q4 compared with the Q1 group (OR: 0.610, 95% CI: 0.403, 0.921, p = .022; OR: 0.592, 95% CI: 0.367, 0.954, p = .034). Meanwhile, niacin was negatively associated with poor cognition as assessed by the CERAD-WL test, CERAD test, AFT, and DSST. An L-shaped dose-response relationship between dietary niacin and cognitive function was observed in all participants (nonlinear p < .001). There were also interactions that existed in populations with different carbohydrate intakes and cholesterol intakes (p for interaction = .031, p for interaction = .005). These findings provide new evidence for the potential role of dietary niacin intake on cognitive function in the elderly.

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Dietary Magnesium Intake Affects the Association Between Serum Vitamin D and Type 2 Diabetes: A Cross-Sectional Study

Cited by 18 publications

References 33 publications

The relationship between soluble CD73 and the incidence of septic shock in severe sepsis patients: a cross-sectional analysis of data from a prospective FINNAKI study

The relationship between soluble CD73 and the incidence of septic shock in severe sepsis patients: a cross-sectional analysis of data from a prospective FINNAKI study

Dietary Magnesium Intake Affects the Vitamin D Effects on HOMA-β and Risk of Pancreatic β-Cell Dysfunction: A Cross-Sectional Study

Association between dietary niacin intake and cognitive function in the elderly: Evidence from NHANES 2011–2014

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