Dietary interventions for multiple sclerosis

Abstract

PUFAs seem to have no major effect on the main clinical outcome in MS (disease progression), but they may tend to reduce the frequency of relapses over two years. However, the data that are available are insufficient to assess a real benefit or harm from PUFA supplementation because of their uncertain quality.Evidence on the possible benefits and risks of vitamin supplementation and antioxidant supplements in MS is lacking. More research is required to assess the effectiveness of dietary interventions in MS.

Selected health behaviors moderate the progression of functional limitations in persons with multiple sclerosis: Eleven years of annual follow-up

“…In addition, exercise (higher) and health responsibility (lower) scores were associated with slower rates of functional limitation progression. Consistent with recent Cochrane reviews [7,8], self-reported nutrition behaviors had no effect on functional limitations at Year 11 or the rate of progression.…”

Selected health behaviors moderate the progression of functional limitations in persons with multiple sclerosis: Eleven years of annual follow-up

“…In addition, exercise (higher) and health responsibility (lower) scores were associated with slower rates of functional limitation progression. Consistent with recent Cochrane reviews [7,8], self-reported nutrition behaviors had no effect on functional limitations at Year 11 or the rate of progression.…”

The effect of omega-3 fatty acids on central nervous system remyelination in fat-1 mice

“…As compared to our analysis in mice, a meta-analysis by Farinotti et al [20] has concluded that n-3 PUFAs did not have an effect on 292 patients with relapsing remitting MS. However, there are several arguments why a positive effect of n-3 PUFAs on remyelination in patients suffering from MS might not have shown up in the two studies that were evaluated by Farinotti and colleagues [13, 41]: Patients in both studies received EPA at 1.71 and 1.98 g/d and DHA at 1.14 and 1.32 g/d, (which is well above the general dietary recommendations by most nutritional guidelines).…”

Nutrition Facts in Multiple Sclerosis

“…In particular, as reported by Farinotti et al. in their Cochrane review ( 2012 ), supplements such as n-3 PUFA seem to have no major effect on the main clinical outcome in MS, but they may reduce the frequency of relapses over 2 years. Data available were considered to be insufficient or of uncertain quality to assess a real effect from PUFA supplementation.…”

Selected health behaviors moderate the progression of functional limitations in persons with multiple sclerosis: Eleven years of annual follow-up

“…In addition, exercise (higher) and health responsibility (lower) scores were associated with slower rates of functional limitation progression. Consistent with recent Cochrane reviews [7,8], self-reported nutrition behaviors had no effect on functional limitations at Year 11 or the rate of progression.…”

The effect of omega-3 fatty acids on central nervous system remyelination in fat-1 mice

“…As compared to our analysis in mice, a meta-analysis by Farinotti et al [20] has concluded that n-3 PUFAs did not have an effect on 292 patients with relapsing remitting MS. However, there are several arguments why a positive effect of n-3 PUFAs on remyelination in patients suffering from MS might not have shown up in the two studies that were evaluated by Farinotti and colleagues [13, 41]: Patients in both studies received EPA at 1.71 and 1.98 g/d and DHA at 1.14 and 1.32 g/d, (which is well above the general dietary recommendations by most nutritional guidelines).…”

Nutrition Facts in Multiple Sclerosis

“…In particular, as reported by Farinotti et al. in their Cochrane review ( 2012 ), supplements such as n-3 PUFA seem to have no major effect on the main clinical outcome in MS, but they may reduce the frequency of relapses over 2 years. Data available were considered to be insufficient or of uncertain quality to assess a real effect from PUFA supplementation.…”

Selected health behaviors moderate the progression of functional limitations in persons with multiple sclerosis: Eleven years of annual follow-up

“…In addition, exercise (higher) and health responsibility (lower) scores were associated with slower rates of functional limitation progression. Consistent with recent Cochrane reviews [7,8], self-reported nutrition behaviors had no effect on functional limitations at Year 11 or the rate of progression.…”

The effect of omega-3 fatty acids on central nervous system remyelination in fat-1 mice

“…As compared to our analysis in mice, a meta-analysis by Farinotti et al [20] has concluded that n-3 PUFAs did not have an effect on 292 patients with relapsing remitting MS. However, there are several arguments why a positive effect of n-3 PUFAs on remyelination in patients suffering from MS might not have shown up in the two studies that were evaluated by Farinotti and colleagues [13, 41]: Patients in both studies received EPA at 1.71 and 1.98 g/d and DHA at 1.14 and 1.32 g/d, (which is well above the general dietary recommendations by most nutritional guidelines).…”

Nutrition Facts in Multiple Sclerosis

“…In particular, as reported by Farinotti et al. in their Cochrane review ( 2012 ), supplements such as n-3 PUFA seem to have no major effect on the main clinical outcome in MS, but they may reduce the frequency of relapses over 2 years. Data available were considered to be insufficient or of uncertain quality to assess a real effect from PUFA supplementation.…”