Dietary Intakes of Glutamic Acid and Glycine Are Associated with Stroke Mortality in Japanese Adults ,

Nagata, Chisato; Wada, Keiko; Tamura, Takashi; Kawachi, Toshiaki; Konishi, Kie; Tsuji, Michiko; Nakamura, Kozue

doi:10.3945/jn.114.201293

Cited by 25 publications

(39 citation statements)

References 27 publications

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“…Dietary glycine and methionine that are mainly consumed from animal-based foods have been shown to be positively associated with T2D, hypertension, and stroke mortality in previous cohort studies (36)(37)(38). The dietary amino acid composition may partly explain the association between animal protein intake and the development of T2D.…”

Section: Discussionmentioning

confidence: 92%

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Dietary protein intake and risk of type 2 diabetes: results from the Melbourne Collaborative Cohort Study and a meta-analysis of prospective studies

Shang

Scott

Hodge

et al. 2016

The American Journal of Clinical Nutrition

104

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Background: Reported associations between protein intake from different sources and type 2 diabetes (T2D) have been inconsistent. Objective: We prospectively examined the relations of total, animal, and plant protein intakes with incident T2D. Design: We followed 21,523 participants (women: 61.7%) between 1990 and 2007 from the Melbourne Collaborative Cohort Study who were free of diabetes, cardiovascular disease, cancer, and kidney stones at baseline. We also conducted a meta-analysis that included the results from our cohort and from 10 previous prospective studies. Results: A total of 929 new cases (4.3%) of T2D were documented during a mean of 11.7 y of follow-up. Multivariate-adjusted ORs for incident T2D in the highest compared with lowest quintiles of total and animal protein intakes as percentages of energy were 1.23 (95% CI: 0.96, 1.56; P-trend = 0.029) and 1.29 (95% CI: 0.99, 1.67; P-trend = 0.014), respectively. These associations appeared to be greater in men and in participants with normal baseline plasma glucose, body mass index, or blood pressure. Plant protein intake was inversely associated with incident T2D in women only (OR; 0.60; 95% CI: 0.37, 0.99). In the meta-analysis of 11 prospective cohort studies with 505,624 participants and 37,918 T2D cases (follow-up range: 5-24 y), pooled RRs for the comparison of the highest with lowest categories of total, animal, and plant protein intakes were 1.09 (95% CI: 1.06, 1.13), 1.19 (95% CI: 1.11, 1.28), and 0.95 (95% CI: 0.89, 1.02), respectively. Associations between animal protein intake and T2D were similar across sex, geographic region, length of follow-up, study quality, and method of expressing protein intake. An inverse association between plant protein intake and T2D was observed in women (RR: 0.93; 95% CI: 0.85, 1.00) and in US populations (RR: 0.91; 95% CI: 0.84, 0.97). Conclusion: Higher intakes of total and animal protein were both associated with increased risks of T2D, whereas higher plant protein intake tended to be associated with lower risk of T2D.Am J Clin Nutr 2016;104:1352-65.

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Section: Discussionmentioning

confidence: 92%

“…The potential benefits of high intake of plant protein in the prevention of T2D might also be related to the amino acid composition. Dietary glutamic acid, which is an amino acid that is mainly consumed from plant protein, is inversely associated with risks of hypertension, arterial stiffness, and stroke mortality (38)(39)(40).…”

Section: Discussionmentioning

confidence: 99%

Dietary protein intake and risk of type 2 diabetes: results from the Melbourne Collaborative Cohort Study and a meta-analysis of prospective studies

Shang

Scott

Hodge

et al. 2016

The American Journal of Clinical Nutrition

104

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“…The present study included 29,079 subjects with no history of cancer, stroke, or coronary heart disease. The details of the study design and subjects have been described previously (14,15).…”

Section: Methodsmentioning

confidence: 99%

“…Diet including alcohol intake was assessed with a 169-item semiquantitative FFQ at the baseline. Details of the method of calculating nutrient intakes from the FFQ and its reliability and validity were previously described (15,16). Nutrient values in foods including folate and B vitamins were obtained from the Japanese Standard Tables of Food Composition, 5th revised and enlarged edition, published by the Science and Technology Agency of Japan (17).…”

Section: Methodsmentioning

confidence: 99%

Choline and Betaine Intakes Are Not Associated with Cardiovascular Disease Mortality Risk in Japanese Men and Women

Nagata

Wada

Tamura

et al. 2015

The Journal of Nutrition

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“…The relationship between the types of dietary protein intake and cardiovascular disease (CVD) also remains unclear. Some epidemiological studies have shown no association between any kind of protein intake and CVD [16][17][18][19] , whereas other studies reported inverse associations between animal protein intake and intracerebral hemorrhage 20,21) or any type of protein and risk of cerebral infarction 22) . However, to our knowledge only a few reports have suggested an inverse association between vegetable protein intake and risk of CVD 23) .…”

Section: Dietary Surveymentioning

confidence: 99%

Vegetable Protein Intake was Inversely Associated with Cardiovascular Mortality in a 15-Year Follow-Up Study of the General Japanese Population

Kurihara

Okamura

Sugiyama

et al. 2019

J Atheroscler Thromb

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Aim: To examine the relationship between the intake of dietary vegetable protein and CVD mortality in a 15-year follow-up study of a representative sample of the Japanese population.Methods: A total of 7,744 participants aged 30 years or older (3,224 males and 4,520 females) who were free of CVD at baseline were included in this analysis. Vegetable protein intake (% energy) was assessed using a threeday semi-weighed dietary record at baseline. Multivariable-adjusted hazard ratios (HRs) were calculated using Cox's proportional hazards model after adjusting for confounding factors. Results:The total person-years studied were 107,988 with a mean follow-up period of 13.9 years. There were 1,213 deaths during the follow-up period, among which 354 (29.2%) were due to CVD. Vegetable protein intake was associated inversely with CVD and cerebral hemorrhage mortality, with the HRs for a 1% energy increment in vegetable protein intake being 0.86 (95% CI, 0.75 -0.99) and 0.58 (95% CI, 0.35 -0.95), respectively. In the subgroup analysis of participants with or without hypertension, the inverse association between vegetable protein intake and CVD mortality was more evident in the nonhypertensive group, with the HRs for CVD and stroke being 0.68 (95% CI, 0.50 -0.94) and 0.50 (95% CI, 0.30 -0.84), respectively.Conclusions: Vegetable protein intake may prevent future CVD, particularly in nonhypertensive subjects in the Japanese population. However, further studies are necessary to examine the biological mechanisms of this effect.

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Dietary Intakes of Glutamic Acid and Glycine Are Associated with Stroke Mortality in Japanese Adults ,

Abstract: The data suggest that glutamic acid and glycine intakes may be associated with risk of stroke mortality. Given that this is an initial observation, our results need to be confirmed.

Cited by 25 publications

References 27 publications

Dietary protein intake and risk of type 2 diabetes: results from the Melbourne Collaborative Cohort Study and a meta-analysis of prospective studies

Dietary protein intake and risk of type 2 diabetes: results from the Melbourne Collaborative Cohort Study and a meta-analysis of prospective studies

Choline and Betaine Intakes Are Not Associated with Cardiovascular Disease Mortality Risk in Japanese Men and Women

Vegetable Protein Intake was Inversely Associated with Cardiovascular Mortality in a 15-Year Follow-Up Study of the General Japanese Population

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