Dietary intake of glucono-δ-lactone attenuates skin inflammation and contributes to maintaining skin condition

Abstract

Skin properties are influenced by both external (e.g., ultraviolet [UV], chemicals, and bacteria) and internal factors (e.g., nutrition and hormones). Therefore, some dietary supplements are expected to improve skin conditions. Glucono-δ-lactone (GDL) is widely used as a food additive and is naturally present in wine, honey, and other foods. The aim of this study was to assess whether GDL improves skin condition and inflammation. In a double-blind, placebo-controlled study, 40 healthy Japanese male volunteers were randomly assigned to either the GDL (2000 mg day) or placebo group. A significant difference was found in the rates of change in transepidermal water loss (TEWL) from the baseline to 6 months between the placebo and GDL groups (P < 0.05). Facial lightness (L*) significantly increased by 1.6% only in the GDL group at 6 months compared with the baseline. The value of the elasticity parameter, Ua/Uf, of dietary GDL significantly increased (6.2% at 2 months and 5.4% at 6 months). Besides these, dietary GDL suppressed UVB-induced erythema (a*) and pigmentation (L*). Dietary GDL has anti-inflammatory effects on the skin and prevents/improves skin disorders caused by seasonal change.

Evaluation of the effects of 10% and 30% gluconolactone chemical peel on sebum, pH, and TEWL

“…Therefore, dietary GDL could improve skin barrier function, elasticity, and viscoelasticity. Comparing the results of our own study with those above on the use of oral GLA, we can conclude that topical GLA has a moisturizing effect on the most superficial layers of the skin (reducing TEWL) and oral GLA has a stronger effect on strengthening the layers of the dermis by improving the viscoelasticity of the skin by improving the quality of the interstitial fluid throughout the fibrous network 13 …”

“…skin (reducing TEWL) and oral GLA has a stronger effect on strengthening the layers of the dermis by improving the viscoelasticity of the skin by improving the quality of the interstitial fluid throughout the fibrous network. 13 In skin care processes, it should also be borne in mind that the acidic pH of the skin's mantle affects the proper course of physiological processes, such as lipid barrier formation and stratum corneum homeostasis (pH-dependent enzyme work, exfoliation, and antimicrobial defense). Proper pH regulation is necessary to prevent infections and reduce the susceptibility of the skin to inflammation.…”

Protective Effect of Potentilla glabra in UVB-Induced Photoaging Process

“…However, because UVC is almost completely absorbed by the ozone layer and atmosphere, UVB is the most damaging electromagnetic radiation. Several studies have reported the harmful effects of UVB on skin, such as skin photoaging [ 14 , 15 , 16 ], DNA damage and increased oxidative stress [ 17 , 18 ], and skin inflammation through various mechanisms [ 19 , 20 , 21 , 22 ].…”

New Discovery of Covid-19 Natural-Based Antivirus Herbal Supplement Products from Pinang Yaki (Areca vestiaria) Extract by Untargeted Metabolomic Profiling

“…In addition, choline (PubChem ID: 305) which is the Top 10 Metabolite from pinang yaki extract (ESI+) has also been widely researched for its effects in preventing SARS Cov-2 Infection and has good neuroprotective immunity (Chowdhury & Pathak., 2020). Other contents in pinang yaki (Areca vestiaria) such as Benzothiazole (PubChem ID: 7222) (Ali & Siddiqui., 2013), L-Isoleucine (PubChem ID: 6306) (Mao et al, 2018), D-Glucono-Delta-Lactone (PubChem ID: 736) (Kuwano et al, 2018) The above compounds have been identified as contained in pinang yaki extract, which shows its potential as a Covid-19 antiviral herbal supplement product. Of course, it needs further study, researchers will conduct an in vivo study to find out the effect of pinang yaki extract as an antiviral herbal supplement Covid-19 (based on the results of the compounds or metabolomic profiling in this paper).…”