Dietary Intake of Flavonoids and Carotenoids Is Associated with Anti-Depressive Symptoms: Epidemiological Study and In Silico—Mechanism Analysis

Park, Seon-Joo; Jaiswal, Varun; Lee, Hae‐Jeung

doi:10.3390/antiox11010053

Cited by 22 publications

(25 citation statements)

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“…14 of the included studies were performed in Asian countries [Korea ( 14 , 20 , 21 , 25 , 29 , 30 , 35 , 36 ), Iran ( 18 , 31 , 33 ), Japan ( 13 , 23 ) and China ( 28 )], and the other ones were conducted in United States ( 15 , 17 , 27 , 32 , 34 ), Brazil ( 26 , 37 ), Australia ( 16 ), Spain ( 22 , 24 ), and Turkey ( 19 ). Male, female and both male and female participants were recruited in 1 ( 18 ), 8 ( 14 , 20 , 26 , 28 , 30 , 31 , 33 , 36 ), and 16 ( 13 , 15 – 17 , 19 , 21 – 25 , 27 , 29 , 32 , 34 , 35 , 37 ) studies, respectively. The sample size ranged from 41 to 17,401 for a total number of 100,955.…”

Section: Resultsmentioning

confidence: 99%

“…The sample size ranged from 41 to 17,401 for a total number of 100,955. The exposure was assessed by food-frequency questionnaire (FFQ) in 16 studies ( 13 – 16 , 18 , 20 , 21 , 23 – 25 , 28 , 29 , 31 , 33 , 36 , 37 ), and recall method in 9 studies ( 17 , 19 , 22 , 26 , 27 , 30 , 32 , 34 , 35 ). The diagnostic criteria of depression were Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) ( 15 , 17 , 19 , 24 ), Patient Health Questionnaire-9 (PHQ-9) ( 27 , 29 , 32 , 34 ), Center for Epidemiological Studies Depression Scale (CES-D) ( 13 , 14 , 16 , 22 , 28 , 30 ), Beck Depression Inventory (BDI) ( 18 , 20 , 21 , 26 , 33 , 36 ), Geriatric Depression Scale (GDS) ( 23 ), Clinical Interview Schedule Revised (CIS-R) ( 37 ), and Depression, Anxiety, Stress Scale (DASS) ( 31 ), respectively.…”

Section: Resultsmentioning

confidence: 99%

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Associations of Dietary Vitamin A and Beta-Carotene Intake With Depression. A Meta-Analysis of Observational Studies

2022

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ObjectiveTo clarify the associations of dietary vitamin A and beta-carotene intake with depression based on a meta-analysis of observational studies.MethodsAn extensive literature search on February 2022 (PubMed, Web of Science and Embase) was employed to identify observational studies on the associations of dietary vitamin A and beta-carotene intake with depression. The pooled relative risk (RR) of depression for the highest vs. lowest dietary vitamin A and beta-carotene intake category, and the standard mean difference (SMD) of dietary vitamin A and beta-carotene intake for depression vs. control subjects, were calculated.ResultsA total of 25 observational studies (100,955 participants), which included 24 cross-sectional/case-control and 1 prospective cohort study, were included in this study. The overall multi-variable adjusted RR demonstrated that dietary vitamin A intake was inversely associated with depression (RR = 0.83, 95%CI: 0.70–1.00; P = 0.05). In addition, the combined SMD showed that the dietary vitamin A intake in depression was also lower than that in control subjects (SMD = −0.13, 95%CI: −0.18 to −0.07; P < 0.001). On the other hand, the overall multi-variable adjusted RR indicated that dietary beta-carotene intake was negatively associated with depression (RR = 0.63, 95%CI: 0.55–0.72; P < 0.001). The combined SMD showed that the dietary beta-carotene intake in depression was also lower than that in control subjects (SMD = −0.34, 95%CI: −0.48 to −0.20; P < 0.001).ConclusionOur results suggest that both dietary vitamin A and beta-carotene intake is inversely associated with depression. However, due to the limited evidence, further prospective cohort studies are still needed.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Associations of Dietary Vitamin A and Beta-Carotene Intake With Depression. A Meta-Analysis of Observational Studies

2022

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“…In order to ensure the normal operation of the inverter, it is necessary to carry out real-time monitoring and online diagnosis [1]. In the inverter fault, the short circuit and open circuit of the power device are the most frequent faults of the inverter.…”

Section: Related Workmentioning

confidence: 99%

A New Method for Inverter Diagnosis of Electric Locomotive Using Adversarial Neural Networks

Shi

Chen

Luo

2022

Security and Communication Networks

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In order to improve the fault diagnosis accuracy of the electric locomotive inverter, this article combines the adversarial neural network to construct the electric locomotive inverter diagnosis system. Moreover, at the data level, this article compares and analyzes three methods of data expansion based on single-sample processing, data expansion based on image front and background separation, and data expansion based on an adversarial neural network. In addition, this article adopts a new feature extractor and increases the penalty cost of small samples being misclassified. Finally, this article uses the LBP operator to extract the image texture features to distinguish and detect the different shapes of the rotor windings and build an intelligent system to verify the effect of the proposed system model. The experimental research shows that the inverter diagnosis system for electric locomotives based on the proposed adversarial neural network has a good practical effect.

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“…Similarly, in the National Health and Nutrition Examination Survey of the United States, the intake of total carotenoids and all carotenoid subgroups was negatively correlated with depression symptoms [ 39 ]. These results suggest that carotenoids have potential therapeutic effects [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Intake of Carotenoids and Risk of Depressive Symptoms: A Systematic Review and Meta-Analysis

Xue

et al. 2022

Antioxidants

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Given the important role of oxidative stress in the pathogenesis of depression, the potential role of dietary antioxidant supplementation in the prevention of depression has attracted considerable attention. Most studies suggest that dietary carotenoids may play a role in maintaining depressive symptoms due to their antioxidant activity, but some studies concluded the contrary. This study conducted a meta-analysis of observational studies to test the relationship between carotenoid supplements and depressive symptoms. After a comprehensive search of the Cochrane Library, PubMed, Embase Scopus, and Web of Science databases from their inception to 28 July 2022, 12 publications met the inclusion and exclusion criteria, of which 8 were cross-sectional studies, 3 were case–control studies, and 1 was a cohort study, involving a total of 33,466 participants. Pooled meta-analysis found that intake of total carotenoids (OR = 0.61, 95% CI [0.53, 0.71], p < 0.01), beta-carotene (OR = 0.61, 95% CI [0.52, 0.70], p < 0.01), alpha-carotene (OR = 0.71, 95% CI [0.60, 0.83], p < 0.01), lycopene (OR = 0.71, 95% CI [0.55, 0.90], p < 0.01), lutein, and/or corn xanthin (OR = 0.53, 95% CI [0.43, 0.66], p < 0.01) was significantly inversely associated with depressive symptoms, while beta-cryptoxanthin (OR = 1.07, 95% CI [0.52, 2.21], p = 0.86) had no significance. At the same time, this meta-analysis was free of publication bias and heterogeneity. Although further studies are needed to elucidate the causal relationship between carotenoids and depressive symptoms, and to further reveal the mechanism of their association, the results of our meta-analysis suggest that carotenoids are protective factors for depressive symptoms, and dietary intake may help in reducing the risk of depressive symptoms.

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Dietary Intake of Flavonoids and Carotenoids Is Associated with Anti-Depressive Symptoms: Epidemiological Study and In Silico—Mechanism Analysis

Cited by 22 publications

References 62 publications

Associations of Dietary Vitamin A and Beta-Carotene Intake With Depression. A Meta-Analysis of Observational Studies

Associations of Dietary Vitamin A and Beta-Carotene Intake With Depression. A Meta-Analysis of Observational Studies

A New Method for Inverter Diagnosis of Electric Locomotive Using Adversarial Neural Networks

Dietary Intake of Carotenoids and Risk of Depressive Symptoms: A Systematic Review and Meta-Analysis

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