Dietary habits, lifestyle factors and neurodegenerative diseases

Popa‐Wagner, Aurel; Dumitraşcu, Dinu Iuliu; Capitanescu, Bogdan; Petcu, Eugen Bogdan; Surugiu, Roxana; Fang, Wen‐Hui; Dumbrava, Danut-Adrian

doi:10.4103/1673-5374.266045

Cited by 127 publications

(80 citation statements)

References 63 publications

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“…NIHSS assessments describe the stroke severity and are an important descriptor of stroke recovery and outcome. Further, Comorbidities such as diabetes, high blood pressure, history of smoking, heart disease, and other vascular risk factors stemming from lifestyle factors could cause small-vessel disease 17,18 and reduce blood supply to the thalamus, in turn influencing the thalamus volume. The complex interplay of different comorbidities on stroke outcome and recovery is thought to influence the effect of neuroprotective drugs and their outcome in clinical trials 19 .…”

Section: Discussionmentioning

confidence: 99%

The effect of time since stroke, gender, age, and lesion size on thalamus volume in chronic stroke: a pilot study

Krishnamurthy

Champion

McGregor

et al. 2020

Sci Rep

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Recent stroke studies have shown that the ipsi-lesional thalamus longitudinally and significantly decreases after stroke in the acute and subacute stages. However, additional considerations in the chronic stages of stroke require exploration including time since stroke, gender, intracortical volume, aging, and lesion volume to better characterize thalamic differences after cortical infarct. This cross-sectional retrospective study quantified the ipsilesional and contralesional thalamus volume from 69 chronic stroke subjects’ anatomical MRI data (age 35–92) and related the thalamus volume to time since stroke, gender, intracortical volume, age, and lesion volume. The ipsi-lesional thalamus volume was significantly smaller than the contra-lesional thalamus volume (t(68) = 13.89, p < 0.0001). In the ipsilesional thalamus, significant effect for intracortical volume (t(68) = 2.76, p = 0.008), age (t(68) = 2.47, p = 0.02), lesion volume (t(68) = − 3.54, p = 0.0008), and age*time since stroke (t(68) = 2.46, p = 0.02) were identified. In the contralesional thalamus, significant effect for intracortical volume (t(68) = 3.2, p = 0.002) and age (t = − 3.17, p = 0.002) were identified. Clinical factors age and intracortical volume influence both ipsi- and contralesional thalamus volume and lesion volume influences the ipsilesional thalamus. Due to the cross-sectional nature of this study, additional research is warranted to understand differences in the neural circuitry and subsequent influence on volumetrics after stroke.

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Section: Discussionmentioning

confidence: 99%

The effect of time since stroke, gender, age, and lesion size on thalamus volume in chronic stroke: a pilot study

Krishnamurthy

Champion

McGregor

et al. 2020

Sci Rep

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“…Neurodegeneration in the CNS is characterized by a progressive loss of distinct groups of neurons in specific regions of the brain, deposition of misfolded proteins in neurons, and alterations in astrocytes (Przedborski et al, 2003 ; Maragakis and Rothstein, 2006 ) which results in cognitive dysfunction, loss of synapses, impaired synaptic plasticity, disrupted neuronal signaling, and cell death. The factors that contribute to neuronal stresses in the CNS are aging, neurodegenerative diseases (NDs), comorbidities such as obesity and diabetes, over nutrition via high calorie intake, a lack of physical activity, and genetic background (Popa-Wagner et al, 2020 ). These stresses and changing physiological demands from oxidative damage, protein aggregation, dietary changes, inflammation, high metabolic demands, are counteracted by cells to maintain cellular, protein, and metabolic homeostasis (Squier, 2001 ; Uttara et al, 2009 ).…”

Section: The Effects Of Age Obesity and Diabetes On Neurodegeneratimentioning

confidence: 99%

Role of Sirtuins in Modulating Neurodegeneration of the Enteric Nervous System and Central Nervous System

et al. 2020

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Neurodegeneration of the central and enteric nervous systems is a common feature of aging and aging-related diseases, and is accelerated in individuals with metabolic dysfunction including obesity and diabetes. The molecular mechanisms of neurodegeneration in both the CNS and ENS are overlapping. Sirtuins are an important family of histone deacetylases that are important for genome stability, cellular response to stress, and nutrient and hormone sensing. They are activated by calorie restriction (CR) and by the coenzyme, nicotinamide adenine dinucleotide (NAD+). Sirtuins, specifically the nuclear SIRT1 and mitochondrial SIRT3, have been shown to have predominantly neuroprotective roles in the CNS while the cytoplasmic sirtuin, SIRT2 is largely associated with neurodegeneration. A systematic study of sirtuins in the ENS and their effect on enteric neuronal growth and survival has not been conducted. Recent studies, however, also link sirtuins with important hormones such as leptin, ghrelin, melatonin, and serotonin which influence many important processes including satiety, mood, circadian rhythm, and gut homeostasis. In this review, we address emerging roles of sirtuins in modulating the metabolic challenges from aging, obesity, and diabetes that lead to neurodegeneration in the ENS and CNS. We also highlight a novel role for sirtuins along the microbiota-gut-brain axis in modulating neurodegeneration.

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“…The incidence of most of the neurodegenerative diseases increases with age and is considered multifactorial. Apart from the increase in age, the occurrence of neurodegenerative diseases is also partly affected by diet and lifestyle practices [ 5 ]. Although there have been several studies in identifying drugs for the treatment of neurodegenerative diseases, one of the significant challenges still faced by the researchers is the inability to regenerate neurons when they are lost [ 6 ].…”

Section: Neurodegenerative Diseasesmentioning

confidence: 99%

Neuroprotective Properties of Green Tea (Camellia sinensis) in Parkinson’s Disease: A Review

et al. 2020

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Neurodegenerative disease is a collective term given for the clinical condition, which results in progressive degeneration of neurons and the loss of functions associated with the affected brain region. Apart from the increase in age, neurodegenerative diseases are also partly affected by diet and lifestyle practices. Parkinson’s disease (PD) is a slow onset neurodegenerative disorder and the second most common neurodegenerative disease, which affects the motor system. Although there is no prescribed treatment method to prevent and cure PD, clinical procedures help manage the disease symptoms. Green tea polyphenols are known for several health benefits, including antioxidant, anti-inflammatory, and neuroprotective activity. The current manuscript summarizes the possible mechanisms of neuroprotective potential of green tea with a special focus on PD. Studies have suggested that the consumption of green tea protects against free-radicals, inflammation, and neuro-damages. Several in vivo studies aid in understanding the overall mechanism of green tea. However, the same dose may not be sufficient in humans to elicit similar effects due to complex physiological, social, and cultural development. Future research focused on more clinical trials could identify an optimum dose that could impart maximum health benefits to impart neuroprotection in PD.

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Dietary habits, lifestyle factors and neurodegenerative diseases

Cited by 127 publications

References 63 publications

The effect of time since stroke, gender, age, and lesion size on thalamus volume in chronic stroke: a pilot study

The effect of time since stroke, gender, age, and lesion size on thalamus volume in chronic stroke: a pilot study

Role of Sirtuins in Modulating Neurodegeneration of the Enteric Nervous System and Central Nervous System

Neuroprotective Properties of Green Tea (Camellia sinensis) in Parkinson’s Disease: A Review

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