Dietary habits and stomach cancer in Mizoram, India

Phukan, Rup Kumar; Narain, Kanwar; Zomawia, Eric; Hazarika, N C; Mahanta, Jagadish

doi:10.1007/s00535-006-1761-x

Cited by 67 publications

(49 citation statements)

References 23 publications

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“…It was also reported that H. pylori was more common in diffuse type of cancer than intestinal type (86% vs 68%). Another study from Northern India reported the prevalence of H. pylori as high as 74% in controls as compared to 68% in gastric cancer cases (Phukan et al, 2006). A study from Mizoram reported higher rate of infection by H. pylori in stomach cancer patients (Parkin, 2006).…”

Section: Discussionmentioning

confidence: 97%

“…A study from North India reported the prevalence of H. pylori infection to be 56.5% in gastric cancer patients (Ghoshal et al, 2008). A study from Mizoram reported higher rate of infection by H. pylori in stomach cancer patients (Phukan RK 2006 et al). Same study from Northern India reported the prevalence of H. pylori as high as 74% in controls as compared to 68% in gastric cancer cases.…”

Section: Introductionmentioning

confidence: 99%

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Helicobacter pylori Infection and a P53 Codon 72 Single Nucleotide Polymorphism: a Reason for an Unexplained Asian Enigma

Pandey¹,

Misra²,

Misra³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Aim: P53, the most commonly mutated tumor suppressor gene in all types of human cancer, is involved in cell cycle arrest and control of apoptosis. Although p53 contains several polymorphic sites, the codon 72 polymorphism is by far more common. There are divergent reports but many studies suggest p53 pro/pro SNP may be associated with susceptibility to developing various cancers in different regions of the world. The present study aimed to find any correlation between H. pylori infection and progression of carcinogenesis, by studying apoptosis and the p53 gene in gastric biopsies from north Indian population. Materials and Methods: A total of 921 biopsies were collected and tested for prevalence of H. pylori by rapid urease test (RUT), imprint cytology and histology. Apoptosis was studied by the TUNEL method. Analysis of p53 gene polymorphism at codon 72 was accomplished by PCR using restriction enzyme BstU1. Observation: Out of 921 samples tested 56.7% (543) were H. pylori positive by the three techniques. The mean apoptotic index (AI) in the normal group was 2.12, while gastritis had the maximum 4.24 followed by gastric ulcer 2.28, gastropathy 2.22 and duodenal ulcer 2.08. Mean AI in cases with gastric cancer (1.72) was less than the normal group. The analysis of p53 72 SNP revealed that p53 (Arg/Arg), (Pro /Arg) variant are higher (40.59% & 33.66%) as compared to p53 pro/pro variant (25.74%) inthe healthy population. Conclusions: The North Indian population harbors Arg or Pro/Arg SNP that is capable of withstanding stress conditions; this may be the reason of low incidence of gastric disease in spite of high infection with H. pylori. There was no significant association with H. pylori infection and AI. However, there is increased apoptosis in gastritis which may occur independent of H. pylori or p53 polymorphism.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori Infection and a P53 Codon 72 Single Nucleotide Polymorphism: a Reason for an Unexplained Asian Enigma

Pandey¹,

Misra²,

Misra³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Numerous studies have shown that consumption of alcohol, tobacco and different food habits are important risk factors of stomach cancer in addition to Helicobacter pylori infections (Correa, 1992;Russo et al, 2001;García-G et al, 2012). Earlier studies have shown that tobacco related habits are important risk factors for stomach cancer in Mizoram (Mahanta et al, 1998;Phukan et al, 2006). It was also shown that intake of tobacco in various traditional forms increases the risk of stomach cancer in Mizoram (Phukan et al, 2005).…”

Section: Introductionmentioning

confidence: 97%

Genetic Polymorphism of Glutathione S-transferases M1 and T1, Tobacco Habits and Risk of Stomach Cancer in Mizoram, India

Malakar¹,

Devi²,

Phukan³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Aim: The incidence of stomach cancer in Mizoram is highest in India. We have conducted a population based matched case-control study to identify environmental and genetic risk factors in this geographical area. Methods: A total of 102 histologically confirmed stomach cancer cases and 204 matched healthy population controls were recruited. GSTM1 and GSTT1 genotypes were determined by PCR and H. pylori infections were determined by ELISA. Results: Tobacco-smoking was found to be an important risk factor for high incidence of stomach cancer in Mizoram. Meiziol (local cigarette) smoking was a more important risk factor than other tobacco related habits. Cigarette, tuibur (tobacco smoke infused water) and betel nut consumption synergistically increased the risk of stomach cancer. Polymorphisms of GSTM1 and GSTT1 genes were not found to be directly associated with stomach cancer in Mizoram. However, they appeared to be effect modifiers. Persons habituated with tobacco smoking and/or tuibur habit had increased risk of stomach cancer if they carried the GSTM1 null genotype and GSTT1 non-null genotype. Conclusion: Tobacco smoking, especially meiziol is the important risk factor for stomach cancer in Mizoram. GSTM1 and GSTT1 genes modify the effect of tobacco habits. This study is a first step in understanding the epidemiology of stomach cancer in Mizoram, India.

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“…A unique pattern of tobacco consumption and dietary habits with high incidence of lung cancer was observed in Mizoram (Chaturvedi et al, 1998;Phukan et al, 2006;Malakar et al, 2014). Smoking of tobacco is undoubtly one of predominant risk factor for lung cancer (Tredaniel et al, 1994;Pisani et al, 2006;Sellappa et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Role of Household Exposure, Dietary Habits and Glutathione S-Transferases M1, T1 Polymorphisms in Susceptibility to Lung Cancer among Women in Mizoram India

Phukan

Saikia²,

Borah³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Dietary habits and stomach cancer in Mizoram, India

Abstract: Peculiar food habits in Mizoram might be associated with the high prevalence of stomach cancer in Mizoram along with other factors. H. pylori infection might increase the risk of stomach cancer, or it may play a role as a promoter of stomach cancer in Mizoram.

Cited by 67 publications

References 23 publications

Helicobacter pylori Infection and a P53 Codon 72 Single Nucleotide Polymorphism: a Reason for an Unexplained Asian Enigma

Helicobacter pylori Infection and a P53 Codon 72 Single Nucleotide Polymorphism: a Reason for an Unexplained Asian Enigma

Genetic Polymorphism of Glutathione S-transferases M1 and T1, Tobacco Habits and Risk of Stomach Cancer in Mizoram, India

Role of Household Exposure, Dietary Habits and Glutathione S-Transferases M1, T1 Polymorphisms in Susceptibility to Lung Cancer among Women in Mizoram India

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