Dietary fatty acids and susceptibility to multiple sclerosis

Haase, Stefanie; Haghikia, Aiden; Gold, Ralf; Linker, Ralf A.

doi:10.1177/1352458517737372

Cited by 34 publications

(24 citation statements)

References 41 publications

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“…Propionate has been shown to function in inhibiting the biosynthesis of hepatic cholesterol, regulating food intake and obesity, and inducing hypophagia, which are related to metabolism and energy homeostasis 34,35 . Propionate also lowers lipogenesis and carcinogenesis risk, protects from hypertensive cardiovascular damage, and improves multiple sclerosis [36][37][38] . However, it is likely that the health-promoting effects of propionate are less studied than those of butyrate.…”

Section: Discussionmentioning

confidence: 99%

Dairy Propionibacterium freudenreichii ameliorates acute colitis by stimulating MUC2 expression in intestinal goblet cell in a DSS-induced colitis rat model

Yeom

Lim

2020

Sci Rep

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An intact mucus layer is important in managing inflammatory bowel disease (IBD). Dairy Propionibacterium freudenreichii has probiotic potential, produces propionic acid and is known to promote health. The aim of this study was to evaluate the effects of P. freudenreichii on the improvement of colitis. LS 174T goblet cells and a dextran sodium sulfate (DSS)-induced colitis rat model were used to investigate the P. freudenreichii-induced stimulation of mucin production in vitro and in vivo, respectively. The mRNA and protein expression levels of MUC2, a main component of intestinal mucus, increased in the supernatant of P. freudenreichii culture (SPFC)-treated LS 174 cells. The SPFC and live P. freudenreichii (LPF) reduced the disease activity index (DAI) in the rats with DSS-induced colitis. After treatment with SPFC or LPF, the mRNA levels of typical pro-inflammatory cytokines decreased and the inflammatory state was histologically improved in the rats with DSSinduced colitis. The SPFC and LPF treatments increased the gene and protein expression levels of MUC2 in the rats with DSS-induced colitis compared with the expression levels in the negative control rats, and immunohistochemistry (IHC) showed an increase of the intestinal MUC2 level. In addition, SPFC and LPF augmented the level of propionate in the faeces of the rats with DSS-induced colitis. In conclusion, P. freudenreichii might improve acute colitis by restoring goblet cell number and stimulating the expression of MUC2 in intestinal goblet cells.

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Section: Discussionmentioning

confidence: 99%

Dairy Propionibacterium freudenreichii ameliorates acute colitis by stimulating MUC2 expression in intestinal goblet cell in a DSS-induced colitis rat model

Yeom

Lim

2020

Sci Rep

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“…Multiple Sclerosis (MS) is an inflammatory disease of the central nervous system, leading to demyelination and formation of focal lesions with lymphocyte infiltration [334]. An autoimmune basis of MS depends on the imbalance between pro-inflammatory and anti-inflammatory mechanisms [335]. Animal model of experimental EAE has noted the beneficial effects of FAs mediated by shifting macrophage polarization from an M1-like inflammatory phenotype to an anti-inflammatory M2-like phenotype, which in turn prevents de-myelinization, promotes neuroprotection and re-myelinization [306].…”

Section: Multiple Sclerosismentioning

confidence: 99%

The Influence of Dietary Fatty Acids on Immune Responses

et al. 2019

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Diet-derived fatty acids (FAs) are essential sources of energy and fundamental structural components of cells. They also play important roles in the modulation of immune responses in health and disease. Saturated and unsaturated FAs influence the effector and regulatory functions of innate and adaptive immune cells by changing membrane composition and fluidity and by acting through specific receptors. Impaired balance of saturated/unsaturated FAs, as well as n-6/n-3 polyunsaturated FAs has significant consequences on immune system homeostasis, contributing to the development of many allergic, autoimmune, and metabolic diseases. In this paper, we discuss up-to-date knowledge and the clinical relevance of the influence of dietary FAs on the biology, homeostasis, and functions of epithelial cells, macrophages, dendritic cells, neutrophils, innate lymphoid cells, T cells and B cells. Additionally, we review the effects of dietary FAs on the pathogenesis of many diseases, including asthma, allergic rhinitis, food allergy, atopic dermatitis, rheumatoid arthritis, multiple sclerosis as well as type 1 and 2 diabetes.

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“…Already in the 1950s, Swank et al observed that people who consumed less animal fat had lower rates of MS [ 7 ]. Studies investigating an MS animal model revealed harmful as well as beneficial effects of saturated fats, depending on their aliphatic chain length [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

New Insights on the Nutrition Status and Antioxidant Capacity in Multiple Sclerosis Patients

et al. 2019

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Background: Multiple sclerosis (MS) is a multifactorial disease with unknown etiology. It is assumed to result from interplay between genetic and environmental factors, including nutrition. We hypothesized that there are differences in nutritional parameters between MS patients and healthy controls. Methods: We examined 63 MS patients and 83 healthy controls. Nutritional status was determined by a dietary questionnaire, blood tests, quantification of cell membrane fatty acids, and serum antioxidant capacity. Results: We found that MS patients consumed a more limited diet compared with the healthy group, indicated by a lower average of 31 nutrients and by consumption levels of zinc and thiamine below the recommended daily intake. Both consumption and measured iron values were significantly lower in MS patients, with the lowest measures in the severe MS group. Long saturated fatty acids (>C16) were significantly lower in MS patients, while palmitic and palmitoleic acids were both higher. Serum total antioxidant capacity was significantly lower in the MS group compared with healthy controls, with the lowest measures in patients with severe MS. Conclusions: This study points to a possible correlation between nutritional status and MS. Understanding the clinical meaning of these findings will potentially allow for the development of future personalized dietary interventions as part of MS treatment.

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Dietary fatty acids and susceptibility to multiple sclerosis

Abstract: Dietary SCFAs constitute interesting candidates as safe and potent add-on therapy in the immunomodulatory treatment armamentarium for relapsing-remitting MS.

Cited by 34 publications

References 41 publications

Dairy Propionibacterium freudenreichii ameliorates acute colitis by stimulating MUC2 expression in intestinal goblet cell in a DSS-induced colitis rat model

Dairy Propionibacterium freudenreichii ameliorates acute colitis by stimulating MUC2 expression in intestinal goblet cell in a DSS-induced colitis rat model

The Influence of Dietary Fatty Acids on Immune Responses

New Insights on the Nutrition Status and Antioxidant Capacity in Multiple Sclerosis Patients

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