Dietary consumption of phytochemicals and breast cancer risk in Mexican women

Torres‐Sánchez, Luisa; Galván-Portillo, Marcia; Wolff, Mary S.; López‐Carrillo, Lizbeth

doi:10.1017/s136898000800325x

Cited by 41 publications

(32 citation statements)

References 36 publications

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“…In the present study, the dose-dependent effect of PIN on breast cancer cells was not measured; therefore, it is possible that at higher concentrations this compound may also inhibit the growth of MCF-7 cells. Further studies will be necessary to clarify these points and will be of particular importance considering that a recent case-control study showed a clear and strong inverse correlation (OR = 0.19; 95% CI: 0.06, 0.62; P for trend = 0.006) between the consumption of PIN and breast cancer risk in premenopausal women (36).…”

Section: Discussionmentioning

confidence: 99%

Pinoresinol Inhibits Proliferation and Induces Differentiation on Human HL60 Leukemia Cells

Sepporta

Mazza

Morozzi

et al. 2013

Nutrition and Cancer

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Pinoresinol (PIN), one of the simplest lignans, is the precursor of other dietary lignans that are present in whole-grain cereals, legumes, fruits, and other vegetables. Several experimental and epidemiological evidences suggest that lignans may prevent human cancer in different organs. In this study we investigated the chemopreventive properties of PIN on cell lines derived from different sites either expressing or not the functional tumor suppressor protein p53. It was found that PIN inhibited the proliferation of p53 wild type colon and prostate tumor cells (HCT116 and LNCaP) while in breast cells the inhibition of growth was observed only in p53 mutant cells (MDA-MB-231). A potent antiproliferative activity of PIN was also observed on p53 null cells HL60 (IC50% 8 μM), their multidrug resistant variant HL60R (IC50% 32 μM) and K562. On HL60 cells, PIN caused a block of cell cycle in the G0/G1 phase, induced a weak proapoptotic effect but it was a good trigger of differentiation (NBT reduction and CD11b expression). PIN caused an upregulation of the CDK inhibitor p21(WAF1/Cip1) both at mRNA and protein levels so suggesting that this could be a mechanism by which PIN reduced proliferation and induced differentiation on HL60 cells.

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Section: Discussionmentioning

confidence: 99%

Pinoresinol Inhibits Proliferation and Induces Differentiation on Human HL60 Leukemia Cells

Sepporta

Mazza

Morozzi

et al. 2013

Nutrition and Cancer

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“…FFQs that were used varied in length, ranging from 67 to 208 items. Only one study validated its FFQ specifically for plant lignan assessment (Torres-Sanchez et al, 2008), although a UK study used the combination of an FFQ and 24-h recalls to group participants into quartiles of intake (dos Santos Silva et al, 2004). In addition, the possibility of residual confounding cannot be ruled out.…”

Section: Discussionmentioning

confidence: 99%

Lignans and breast cancer risk in pre- and post-menopausal women: meta-analyses of observational studies

et al. 2009

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Phyto-oestrogens are plant compounds structurally similar to oestradiol, which have been proposed to have protective effects against breast cancer. The main class of phyto-oestrogens in the Western diet is lignans. Literature reports on the effect of lignans in breast cancer risk have been conflicting. We performed three separate meta-analyses to examine the relationships between (i) plant lignan intake, (ii) enterolignan exposure and (iii) blood enterolactone levels and breast cancer risk. Medline, BIOSIS and EMBASE databases were searched for publications up to 30 September 2008, and 23 studies were included in the random effects meta-analyses. Overall, there was little association between high plant lignan intake and breast cancer risk (11 studies, combined odds ratio (OR): 0.93, 95% confidence interval (95% CI): 0.83 -1.03, P ¼ 0.15), but this association was subjected to marked heterogeneity (I 2 ¼ 44%). Restricting the analysis to post-menopausal women, high levels of plant lignan intake were associated with reduced breast cancer risk (7 studies, combined OR: 0.85, 95% CI: 0.78, 0.93, Po0.001) and heterogeneity was markedly reduced (I 2 ¼ 0%). High enterolignan exposure was also associated with breast cancer (5 studies, combined OR: 0.73, 95% CI: 0.57, 0.92, P ¼ 0.009) but, again, there was marked heterogeneity (I 2 ¼ 63%). No association was found with blood enterolactone levels (combined OR: 0.82, 95% CI: 0.59 -1.14, P ¼ 0.24). In conclusion, plant lignans may be associated with a small reduction in post-menopausal breast cancer risk, but further studies are required to confirm these results. (Beral, 2003) have both been associated with increased breast cancer risk. Isoflavones and lignans are plant compounds structurally similar to 17b-oestrodiol known as phyto-oestrogens, capable of oestrogen receptor binding (Kuiper et al, 1998;Mueller et al, 2004). Isoflavones are mostly found in soybean products, which are a staple of the Asian diet, whereas lignans are the principal group of phyto-oestrogens in Western diets. Lignans are more widespread in foods than isoflavones and are present in grain cereals, vegetables, seeds, tea and coffee (Mazur, 1998a;Mazur et al, 1998b). Microflora in the colon (Setchell et al, 1981) convert plant lignans into enterolignans, which are detectable in blood and urine. Their levels have been correlated with the amount of plant lignans ingested (Nesbitt et al, 1999).In a recent meta-analysis, an inverse dose-response relationship was shown between breast cancer risk and soy-food intake in Asian, but not in Western women (Wu et al, 2008). Lignans have been shown to exhibit anti-carcinogenic properties (Wang et al, 1994;Prasad 2000;Bergman Jungeström et al, 2007), and it is hypothesised that exposure to high levels may be associated with a reduction in breast cancer risk. However, results from a number of studies in Western populations have been variable. The aim of our systematic review was to establish whether an association exists between lignan exposure and breast cancer ris...

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“…Los países con mayor número de estudios publicados son Uruguay [7][8][9]11,12,14,17,18 y México 10,13,[19][20][21][22][23]30 (33 y 30% de las publicaciones, respectivamente) (cuadro I). En Uruguay, los estudios se han enfocado sobre todo en el consumo de carnes y sus métodos de preparación.…”

Section: Resultsunclassified

“…La investigación sobre dieta y CM conducida en diferentes países de Latinoamérica ha contribuido al estado del arte y muestra en particular el efecto protector de los vegetales y frutas, 5,9 el pescado, 12 la fibra, 17 la vitamina B 12 y el folato, 21 varios fitoestrógenos (en particular el flaván 3-ol y el pinoresinol), 23 el licopeno 9 y las grasas poliinsaturadas, 18,19 además del incremento del riesgo potencial de la elevada ingestión calórica, 5 el consumo de carnes rojas, 7,8,15,16 carnes procesadas, 14 la forma de preparación de las carnes, 12 leche y algunos productos lácteos, 11 grasas saturadas 7 y sacarosa, 20 además de compuestos secundarios como las aminas heterocíclicas. 8 No obstante, es importante mencionar que pese al gran número de proyectos realizados, un gran porcentaje de ellos carece de las características metodológicas que sustente con rigor científico los resultados.…”

Section: Discussionunclassified

“…15 En México se ha reconocido que el consumo de cebolla y espinaca, 10 grasas poliinsaturadas y vitamina E, 19 vitamina B 12 y folato, 21 además de flavonoles, flavones y otros fitoestrógenos, 23 reduce de modo considerable el riesgo de CM; en contraste, el consumo de hidratos de carbono y en particular la sacarosa lo incrementa. 20 En relación con la mortalidad, un estudio ecológico reciente sugiere que el alto consumo de fibras y magnesio 22 reduce en grado sustancial la mortalidad por CM.…”

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Dieta y cáncer de mama en latinoamérica

et al. 2009

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Breast cancer (BC) is the primary cause of death from malignant tumors in women worldwide. Objective. Review epidemiological studies from the Latin-America and Caribbean (LAC) region. Material and Methods. A systematic search, carried out during June-November 2008 in Mexico of PubMed/Medline, Scielo, and Google identified 27 epidemiological studies in LAC that evaluated associations between diet and BC. Results. The research on diet and BC suggests the protective effect of certain fruits, vegetables, fish, fiber, vitamin B 12 , folate, various phytoestrogens, lycopene, and polyunsaturated fats; as well as the potential risk associated with elevated caloric consumption, consumption of red meat and processed meats, certain meat cooking techniques, milk and some other dairy products, saturated fat, and sucrose. Conclusions. The impact of specific foods and nutrients on breast cancer incidence is inconclusive. Further research is needed on this topic.

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Dietary consumption of phytochemicals and breast cancer risk in Mexican women

Abstract: Objective: To perform an evaluation of selected phytochemicals intake and breast cancer (BC) risk in Mexican women. Design: We conducted hospital-based case-control study.

Cited by 41 publications

References 36 publications

Pinoresinol Inhibits Proliferation and Induces Differentiation on Human HL60 Leukemia Cells

Pinoresinol Inhibits Proliferation and Induces Differentiation on Human HL60 Leukemia Cells

Lignans and breast cancer risk in pre- and post-menopausal women: meta-analyses of observational studies

Dieta y cáncer de mama en latinoamérica

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