Dietary betaine accumulates in the liver and intestinal tissue and stabilizes the intestinal epithelial structure in healthy and coccidia-infected broiler chicks

Kettunen, Hannele; Tiihonen, Kirsti; Peuranen, Seppo; Saarinen, Markku; Remus, Janet C

doi:10.1016/s1095-6433(01)00410-x

Cited by 135 publications

(109 citation statements)

References 34 publications

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“…A previous reported study showed that dietary betaine accumulated in the liver and intestinal tissue and stabilized the intestinal epithelial structure in healthy and coccidia-infected broiler chicks. 42) In the present study, oral administration of betaine resulted in increased accumulation of betaine in heart tissue of Group II animals as compared with Group I rats. Oral pretreatment with betaine significantly attenuated the isoprenaline-induced betaine depletion in heart tissue of Group IV rats as compared with that of Group III animals, indicating its cytoprotective property.…”

Section: Discussionsupporting

confidence: 46%

Biochemical Studies on the Protective Effect of Betaine on Mitochondrial Function in Experimentally Induced Myocardial Infarction in Rats

Ganesan

Rajesh

Anandan

et al. 2007

JOURNAL OF HEALTH SCIENCE

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The present study was designed to examine the cardioprotective effect of betaine on mitochondrial function in isoprenaline-induced myocardial infarction in rats with respect to changes in the mitochondrial energy status and antioxidant defense system. Prior oral treatment with betaine significantly prevented the isoprenaline-induced elevation in the levels of diagnostic maker enzymes [alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and creatine phosphokinase (CPK)] and homocysteine in plasma of the experimental group of rats. Its administration significantly counteracted the isoprenaline-induced aberrations in the myocardial energy status by maintaining the levels of myocardial ATP and betaine contents and the activities of mitochondrial TCA cycle enzymes [isocitrate dehydrogenase (ICDH), α-ketoglutarate dehydrogenase (α-KDH), succinate dehydrogenase (SDH), and malate dehydrogenase (MDH)] and respiratory marker enzymes (NADH dehydrogenase and cytochrome-c-oxidase) at near normalcy. It also exerted an antioxidant effect against isoprenalineinduced myocardial infarction by blocking the induction of mitochondrial lipid peroxidation (LPO). A tendency to minimize the isoprenaline-induced alterations in the level of reduced glutathione (GSH) and in the activities of glutathione-dependent antioxidant enzymes [glutathione peroxidase (GPx) and glutathione-S-transferase (GST)] and antiperoxidative enzymes [superoxide dismutase (SOD) and catalase (CAT)] in the heart mitochondria was also observed. The results of the present study indicate that the overall cardioprotective effect of betaine is probably related to its ability to maintain the myocardial energy status (ATP) at higher level by maintaining the activities of TCA cycle enzymes and respiratory marker enzymes at near normalcy, and/or to its free radical-scavenging ability against isoprenaline-induced lipid peroxidation, which is primarily responsible for the irreversible necrosis of the myocardial membrane.

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Section: Discussionsupporting

confidence: 46%

Biochemical Studies on the Protective Effect of Betaine on Mitochondrial Function in Experimentally Induced Myocardial Infarction in Rats

Ganesan

Rajesh

Anandan

et al. 2007

JOURNAL OF HEALTH SCIENCE

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“…It could be hypothesised that either or both of these contributed to the lack of consistent and significant differences between the basal diet and the basal diet supplemented with FOS or saponin (although as noted above there was a tendency for one of the saponin treatments to give heavier body weights than the basal diet alone or the basal diet supplemented with betaine or FOS). This is further supported by data from others who demonstrated the beneficial effects of betaine in the diets of birds that were subjected to coccidial infections (Kettunen et al, 2001). Glycine has been shown previously to enhance levels of Clostridium perfringens (Dahiya et al, 2005).…”

Section: Acamovic Sandilands Kyriazakis and Sparkssupporting

confidence: 59%

The effect of organic diets on the performance of pullets maintained under semi-organic conditions

Acamovic

Sandilands

Kyriazakis

et al. 2008

Animal

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The effects of organic diets, with or without supplements of betaine, saponin, fructo-oligosaccharide and methionine, on the health, performance and gut flora of pullets were investigated. A comparison was also made between birds fed organic diets and those fed a non-organic diet. Day-old Lohmann Tradition pullets were reared in 24 groups of 64 chicks indoors until 11 weeks, and then in 48 groups of 24 to 27 chicks with access to range until 17 weeks of age. Groups of birds were fed one of eight diets, a conventional rearing diet with supplementary amino acids, an organic basal diet, organic basal plus methionine and organic basal supplemented with one of the test ingredients. At most stages of growth the birds fed the conventional diet and those fed the basal diet with methionine performed better than those that had no supplemental methionine. Other dietary treatments had no consistently significant effect on growth, the microbial populations within the gastro-intestinal tract of the birds or the number of parasite eggs excreted. After 5 weeks with access to range, the birds that were fed three out of five diets regarded as deficient in sulphur amino acids achieved similar weights (P . 0.05) to birds that received diets adequate in sulphur amino acids. Health and welfare of birds fed organic diets was not adversely affected; however, an investigation of birds housed in larger flocks and taken into the laying phase, when physical demands on birds are greatest, is required.

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“…Alguns estudos indicam que a suplementação de betaína pode auxiliar beneficamente o epitélio intestinal (Kettunen et al, 2001) sobretudo mantendo a integridade das vilosidades e promovendo melhora na digestibilidade e absorção dos nutrientes.…”

Section: Resultsunclassified

Efeito da suplementação de betaína em dietas de frangos de corte em condições de termoneutralidade

Sakomura

Barbosa

Silva

et al. 2013

Agraria

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RESUMOO objetivo deste trabalho foi avaliar o efeito da inclusão de betaína em dietas sobre o desempenho e morfometria intestinal de frangos de corte, durante os períodos de 1 a 7 e 8 a 21 dias de idade. Foram utilizados 1.408 pintos de corte machos Cobb, distribuídos aleatoriamente em 4 tratamentos com 16 repetições de 22 aves, em quatro câmaras climáticas. Os tratamentos foram: i) controle positivo -dieta formulada de acordo com as exigências nutricionais da ave; ii) controle negativo -com redução nos níveis de metionina e colina; iii) controle negativo + suplementação de 0,092% de betaína em substituição parcial de metionina e total da colina iv) controle negativo + suplementação de 0,1% de betaína natural em substituição parcial de metionina e total da colina. O consumo de ração, o ganho de peso e a conversão alimentar foram avaliados aos sete e 21 dias de idade. Aos 25 dias avaliaram-se as variáveis altura e profundidade de cripta jejunal, em que os resultados obtidos foram submetidos à análise de variância e teste de comparação de médias; já os resultados obtidos com a suplementação da betaína nas rações demonstraram efeitos positivos apenas no consumo de ração na fase de 1 a 7 dias e altura dos vilos da mucosa do jejuno na fase de 8 a 21 dias. A suplementação de 0,1% betafin (96% de betaína natural) na ração proporcionou melhorias nas características morfológicas do intestino delgado de frangos de corte. Palavras-chave: aditivos, integridade intestinal, metionina Effect of betaine supplementation in diets for broiler chickens on thermoneutral environment ABSTRACTThe aim of this study was to evaluate the effect of inclusion of betaine in broiler diets on performance and intestinal morphology of broilers during periods 1 to 7 and 8 to 21 days old. Were used 1,408 Cobb male broiler, randomly assigned into 4 treatments with 16 replicates of 22 birds in environmental chambers. The treatments were: i) positive control -diet formulated according to the nutritional requirements of the birds; ii) negative control -with reduction levels of methionine and choline; iii) negative control + 0.092% supplementation of betaine in substitution of methionine and total choline; iv) negative control + 0.1% supplementation of natural betaine to replace partial methionine and total choline. Were evaluated feed intake, weight gain and feed conversion at 7 and 21 days old. At 25 days were evaluated crypt height and depth of jejunum. The results were analyzed by ANOVA and mean comparison test. The results obtained with the supplementation of betaine in the feed only demonstrated a positive effect on feed consumption during 1 to 7 days, and villous height of the jejunum in the period of 8 to 21 days. Supplementation of 0.1% betafin (96% natural betaine) in the diet provided significant improvements in the morphological characteristics of the small intestine of broilers.

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Dietary betaine accumulates in the liver and intestinal tissue and stabilizes the intestinal epithelial structure in healthy and coccidia-infected broiler chicks

Cited by 135 publications

References 34 publications

Biochemical Studies on the Protective Effect of Betaine on Mitochondrial Function in Experimentally Induced Myocardial Infarction in Rats

Biochemical Studies on the Protective Effect of Betaine on Mitochondrial Function in Experimentally Induced Myocardial Infarction in Rats

The effect of organic diets on the performance of pullets maintained under semi-organic conditions

Efeito da suplementação de betaína em dietas de frangos de corte em condições de termoneutralidade

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