Dietary Antioxidants and Risk of Parkinson's Disease in the Singapore Chinese Health Study

Abstract

A BS TRACT: Background: Despite experimental evidence implicating oxidative stress in the pathogenesis of PD, epidemiological studies have provided inconsistent associations between dietary antioxidants and risk of developing PD. Furthermore, no study has been done in any Asian population. Objectives: We examined the associations for intake levels of dietary carotenoids (α-carotene, β-carotene, lycopene, β-cryptoxanthin, and lutein) and vitamins (vitamin A, C and E) and the risk of developing PD. Methods: We used data from the Singapore Chinese Health Study, a population-based prospective cohort of 63,257 men and women aged 45 to 74 years during enrollment in 1993-1998. Antioxidant intake was derived from a validated semiquantitative food frequency questionnaire. Incident cases were identified through followup interviews, hospital records, or PD registries through 31 July 2018. Hazard ratios and corresponding 95% confidence intervals were derived from multivariable Cox proportional hazard regression models with adjustment for other lifestyle and dietary factors. Results: During an average 19.4 years of follow-up, 544 incident PD cases were identified. No association was found for dietary carotenoids, individually or summed. Hazard ratio comparing highest to lowest quartile for total carotenoids was 0.98 (95% confidence interval: 0.76-1.28; P trend = 0.83). There were also no clear dose-dependent associations of dietary vitamins A, C, and E with risk of developing PD (all P trend ≥ 0.10). Sensitive analyses with lag time and excluding supplement use did not materially alter results. Conclusions: Intake of dietary antioxidants, such as carotenoids and vitamins, was not associated with the risk of developing PD in Singaporean Chinese.

Dietary β-carotene and vitamin A and risk of Parkinson disease: A protocol for systematic review and meta-analysis

“…Four studies included in our study about vitamin A with the risk of PD (3 case–control studies and 1 cohort study): all showed there were no preventive benefits of dietary vitamin A to PD. [ 19 , 32 , 35 , 37 ]…”

Polygenic Risk Scores in a Prospective Parkinson's Disease Cohort

“…Potential PD cases among the cohort participants were identified from three independent sources 4 . First, three follow‐up interviews were conducted on all surviving cohort participants from 1999 to 2004 (n = 52,322), 2006 to 2010 (n = 39,528), and 2014 to 2016 (n = 17,105).…”

“…Potential PD cases among the cohort participants were identified from three independent sources. 4 First, three follow-up interviews were conducted on all surviving cohort participants from 1999 to 2004 (n = 52,322), 2006 to 2010 (n = 39,528), and 2014 to 2016 (n = 17,105). Participants were asked if they had ever been informed by a physician to have PD and, if yes, the age at which the diagnosis was ascertained.…”

“…Shige Qi, MS, 1 Peng Yin, PhD, 1 Linhong Wang, PhD, 1 Ming Qu, PhD, 2 Ge Lin Kan, PhD, 3 Han Zhang, MS, 1 Qingjun Zhang, MD, 4 Yize Xiao, MD, 5 Ying Deng, MD, 6 Zhong Dong, MD, 7 Yan Shi, MD, 8 Jun Meng, MD, 9 Piu Chan, MD, PhD, 10 * and Zhihui Wang, MD, MS Objective: This study aimed to investigate the prevalence of PD within Chinese communities, particularly in older people.…”

The Role of Vitamins in Neurodegenerative Disease: An Update

“…Further studies will be needed to explore and compare other brain areas for a similar type of activity. Additionally, a Singaporean Chinese cohort-based study also suggested no correlation between dietary antioxidants, such as carotenoids and vitamins (vitamin A, C, and E), and risk of developing PD [57]. A comparative study suggested the relation between risk of PD and intake of carotenoids, VitE and VitC.…”