Dietary and Demographical Risk Factors for Oesophageal Squamous Cell Carcinoma in the Eastern Anatolian Region of Turkey Where Upper Gastrointestinal Cancers are Endemic

Koca, Timur; Arslan, Deniz; Basaran, Hamit; Cerkesli, Arda Kaymak; Taştekin, Didem; Sezen, Duygu; Koca, Ozlem; Binici, Doğan Nasır; Başsorgun, Cumhur İ̇brahim; Özdoğan, Mustafa

doi:10.7314/apjcp.2015.16.5.1913

Cited by 15 publications

(13 citation statements)

References 29 publications

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“…Very large number of the EC patients in current study were living in rural areas (92.4%) and suggest an increased associated risk of EC among people living in rural areas (OR = 25.16). This ndings are in line with study has been conducted in Turkey and reported the association of EC and rural population (p < 0.001) (29) and study in India also showed high prevalence of EC in rural areas (30).…”

Section: Discussionsupporting

confidence: 92%

Socio-demographic risk factors of esophageal carcinoma: A case control study in a tertiary care hospital, Kabul Afghanistan

Saadaat¹,

Abdul‐Ghafar²,

Atta³

et al. 2020

Preprint

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Introduction Esophageal cancer (EC) is 7th most common cancer in world in term of incidence and 6th common cancer in term of mortality. In Afghanistan, EC is the most common cancer in males. The socio-demographic status has been known as associated factor for EC. We carried out this study to determine the associated risk factors with EC in a tertiary hospital in Kabul, Afghanistan. Methodology Unmatched case control study of socio-demographic risk factors and EC was conducted at French Medical Institute for Mother and Children (FMIC). We enrolled and analyzed 132 EC cases and 132 normal controls to find out the associated risk factors for EC Result In current study Esophageal Squamous Cell Carcinoma (ESCC) was the predominant EC type (75.8%). The mean age of the case group is 59.48 ± 9.9 years and in control group is 48.05 ± 11.02, (OR: 1.070, 95% CI, p-value <0.001). Majority of the cases group are male (69.6%) (OR: 3.538, 95% CI, p-value 0.022). Participants living in rural areas have the 25-times higher risk of EC than living in urban regions. Un-educated and lower education are highly associated with the risk of EC (OR: 11.21, 95% CI, p-value: <0.001) as well as, having low Socioeconomic status was also highly associated with the increased risk of EC (OR: 14.08, 95% CI, p-value: <0.001). Having family history in first degree family highly associated with the risk of EC (OR: 4.581, 95% CI, p-value <0.001). Although, the majority of the EC patients were unemployed (93.3%) of which 75% were farmer comparing to control which comprises 55.3% of unemployed statistically in multivariate analysis it showed no significant association with EC. In addition, living area according country zones and provinces, weight and height and ethnicity showed no significant association with EC. Conclusion The study concluded that EC is common cancer in older age groups and, predominance in males. In addition, living in rural areas, being un-educated or having lower education, belonging to low socioeconomic status, and having positive family history in first degree relatives are associated with high risk of EC in our study.

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Section: Discussionsupporting

confidence: 92%

Socio-demographic risk factors of esophageal carcinoma: A case control study in a tertiary care hospital, Kabul Afghanistan

Saadaat¹,

Abdul‐Ghafar²,

Atta³

et al. 2020

Preprint

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“…In addition to these, certain regional food habits are also identified as the potential risk factors associated with the cause of ESCC e.g . consumption of beverages such as tea and coffee (linked to amount and temperature), consumption of nitrogenous component rich food, boiled yellow butter, and moldy cheese etc 7 , 8 . Most often these risk factors are strongly associated with sub-populations as they are linked to region-specific lifestyles.…”

Section: Introductionmentioning

confidence: 99%

ESCC ATLAS: A population wide compendium of biomarkers for Esophageal Squamous Cell Carcinoma

Tungekar¹,

Mandarthi

Mandaviya

et al. 2018

Sci Rep

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Esophageal cancer (EC) is the eighth most aggressive malignancy and its treatment remains a challenge due to the lack of biomarkers that can facilitate early detection. EC is identified in two major histological forms namely - Adenocarcinoma (EAC) and Squamous cell carcinoma (ESCC), each showing differences in the incidence among populations that are geographically separated. Hence the detection of potential drug target and biomarkers demands a population-centric understanding of the molecular and cellular mechanisms of EC. To provide an adequate impetus to the biomarker discovery for ESCC, which is the most prevalent esophageal cancer worldwide, here we have developed ESCC ATLAS, a manually curated database that integrates genetic, epigenetic, transcriptomic, and proteomic ESCC-related genes from the published literature. It consists of 3475 genes associated to molecular signatures such as, altered transcription (2600), altered translation (560), contain copy number variation/structural variations (233), SNPs (102), altered DNA methylation (82), Histone modifications (16) and miRNA based regulation (261). We provide a user-friendly web interface (http://www.esccatlas.org, freely accessible for academic, non-profit users) that facilitates the exploration and the analysis of genes among different populations. We anticipate it to be a valuable resource for the population specific investigation and biomarker discovery for ESCC.

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“…Esophageal and gastric cancers are the most prevalent malignancies in both females and males in eastern part of Turkey 16. The probable culprit factors for ESCC in this region are low educational and socioeconomic status; the consumption of smoked, salted, hot, fatty foods; overconsumption of hot tea; cigarette smoking; poor intake of fresh fruits and vegetables, and poor hygienic conditions 17.…”

Section: Discussionmentioning

confidence: 99%

Helicobacter Pylory infection in patients with esophageal squamous cell carcinoma

Poyrazoglu¹,

Dülger²,

Gültepe³

2017

Clinics

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OBJECTIVE:Esophageal squamous cell carcinoma is one of the most common esophageal diseases in the developing world, but the relationship between esophageal squamous cell carcinoma and Helicobacter pylori infection remains a neglected topic. The primary objective of this study was to determine the association between Helicobacter pylori infection and esophageal squamous cell carcinoma. A second purpose was to determine the incidence and factors associated with Helicobacter pylori infection following esophagectomy.METHOD:The microorganism was identified by testing the gastric biopsy materials from 95 esophageal squamous cell carcinoma patients (66 females; 39 were esophagectomized) for urease activity in a medium containing urea and a power of hydrogen detection reagent and comparing the results with those from a healthy population. Differences in patient characteristics were assessed with chi-square tests and t-tests for categorical and continuous factors, respectively.RESULTS:The patients with esophageal squamous cell carcinoma had a significantly lower prevalence of Helicobacter pylori compared with the healthy population (p<0.001). The naive and esophagectomized patients, in contrast, showed no significant differences in Helicobacter pylori infection (p>0.005). Patients with esophageal squamous cell carcinoma showed a significant association between leukocytosis and hypoglobulinemia and the presence of Helicobacter pylori infection (p=0.023 and p=0.045, respectively).CONCLUSION:These results suggest that Helicobacter pylori is not an etiological factor in patients with esophageal squamous cell carcinoma. We found a statistically significant negative correlation between esophageal squamous cell cancer and Helicobacter pylori infection. These findings may guide new strategies for esophageal squamous cell carcinoma therapy.

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Dietary and Demographical Risk Factors for Oesophageal Squamous Cell Carcinoma in the Eastern Anatolian Region of Turkey Where Upper Gastrointestinal Cancers are Endemic

Cited by 15 publications

References 29 publications

Socio-demographic risk factors of esophageal carcinoma: A case control study in a tertiary care hospital, Kabul Afghanistan

Socio-demographic risk factors of esophageal carcinoma: A case control study in a tertiary care hospital, Kabul Afghanistan

ESCC ATLAS: A population wide compendium of biomarkers for Esophageal Squamous Cell Carcinoma

Helicobacter Pylory infection in patients with esophageal squamous cell carcinoma

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