Diet quality is associated with circulating C-reactive protein but not irisin levels in humans

Park, Kyung-Hee; Zaichenko, Lesya; Peter, Patricia; Davis, Cynthia R.; Crowell, Judith A.; Mantzoros, Christos S.

doi:10.1016/j.metabol.2013.10.011

Cited by 78 publications

(53 citation statements)

References 55 publications

(65 reference statements)

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“…In the other study, BMI levels of women were higher than the men (although not statistically signifi cant). Th e positive correlation between BMI and irisin has been shown in previous studies (Park et al 2014). As for its relation with age, the mean age of women in T1DM group of our study was fairly high compared to the other study.…”

Section: Discussionsupporting

confidence: 68%

Factors associated with increased irisin levels in the type 1 diabetes mellitus

Ateş

Arikan

Erdoğan

et al. 2017

Endocrine Regulations

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Objective. Th e aim of the present study was to determine the irisin levels in patients with the type 1 diabetes mellitus (T1DM) and to examine the relation of irisin levels with the infl ammation and autoimmunity.Methods. Th is study included 35 cases diagnosed with T1DM and 36 healthy volunteers. Antiglutamic acid decarboxylase (anti-GAD), islet cell antibody (ICA), and insulin autoantibody levels were measured in patients at the time when they were included into the study and recorded from the patient fi les. Serum irisin levels were measured by ELISA kit.Results. Th e median irisin levels were determined higher in T1DM group compared to the control one (6.8 ng/ml vs. 4.8 ng/ml, p=0.022; respectively). Median irisin levels were higher in anti-GAD (p=0.022) and ICA (p=0.044) positive groups compared to negative groups. In T1DM group, irisin levels displayed positive correlation with glycosylated hemoglobin (HbA1c) (r=0.377, p<0.001) and anti-GAD (r=0.392, p=0.020) and negative correlation with creatinine (r=-0390, p=0.021). In multivariate regression model, HbA1c (B±SE: 2.76±17683, p<0.001), and anti-GAD (B±SE: 2.311±0.610, p=0.001) were determined as independent predictors for predicting the irisin levels.Conclusion. In patients with T1DM, which chronic infl ammation and autoimmunity take part in their etiopathogenesis, anti-GAD levels were an independent risk factor for the irisin. Th is may suggest that factors such as infl ammation and autoimmunity can be eff ective in the synthesis of irisin.

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Section: Discussionsupporting

confidence: 68%

Factors associated with increased irisin levels in the type 1 diabetes mellitus

Ateş

Arikan

Erdoğan

et al. 2017

Endocrine Regulations

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“…Additionally, oxidative stress and inflammation, which are two mechanisms involved in the onset of insulin resistance [32], were associated with an increase in irisin levels, as was 6 reflected in human muscle [33] and liver [34]. However, the irisin effect appears to be exerted in a nutrition-independent fashion because its circulating levels were not associated with dietary indices [35].…”

Section: Introductionmentioning

confidence: 99%

Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients

et al. 2014

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Objective. Weight regain is associated with the promotion of insulin resistance. The newly discovered myokine irisin, which was proposed to be involved in the management of insulin sensitivity, could play a role in this process. This study aimed to investigate the association between irisin and reduced insulin sensitivity induced by weight regain.Materials/Methods. Insulin sensitivity was evaluated according to the homeostasis model assessment of insulin resistance (HOMA-IR) in 136 obese patients who followed an eight-week hypocaloric diet (30% reduced energy expenditure) to lose weight and were reevaluated four or six months after treatment. Irisin plasma levels, as well as the levels of leptin, adiponectin, ghrelin and TNF-α, were quantified in a sub-cohort (n=73) from the initially studied patients at baseline (T0), at the diet endpoint (T1) and after the follow-up period (T2).Results. After a successful dietary intervention to lose weight, 50% of the patients who regained the lost weight during the follow-up period were categorized as insulin resistant (HOMA-IR≥2.5) compared with only 25% of patients who maintained the weight loss (p=0.018). Importantly, in addition to the well-studied hormones leptin and adiponectin, irisin plasma levels were statistically associated with several risk factors for insulin resistance.Indeed, the increased risk of insulin resistance during the follow-up period was related to high irisin levels at baseline (odds ratio=4.2; p=0.039).Conclusions. Circulating irisin predicts the insulin resistance onset in association with weight regain. Therefore, irisin could be secreted as an adaptive response to counteract the deleterious effect of excess adiposity on glucose homeostasis.

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“…Its level has been reported to be high in patients with insulin resistance (27), metabolic syndrome (28), and obesity (29), and low in cases of anorexia nervosa (30) and type 2 diabetes mellitus (31). Wen et al reported that the irisin level was lower in non-diabetic stage 5 CKD patients not on dialysis than in healthy controls.…”

Section: Discussionmentioning

confidence: 99%

The Serum Irisin Level in Non-Diabetic Patients with Chronic Kidney Disease

Ateş¹,

Ozkayar²,

Arikan³

et al. 2017

Turk Neph Dial Transpl

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OBJECTIVE:Metabolic activity in patients with chronic kidney disease (CKD) is characterized by increased energy expenditure, protein loss, and catabolic processes. Irisin is a recently discovered thermogenic protein that causes energy expenditure. We are in the opinion that the level of irisin may change in patients with CKD and this condition can contribute to the energy expenditure in CKD. The present study aimed to determine the level of serum irisin, in patients with CKD, and the association between CKD stage and the serum irisin level. MATERIAL and METHODS:The study included 90 patients with CKD (stages 2-4) and 32 healthy controls. Routine laboratory tests and measurement of the serum irisin level in all participants were performed. The serum irisin level was measured using the enzyme-linked immunosorbent assay method. RESULTS:The serum irisin level was significantly lower in the patients with CKD than in the control group (p < 0.05). The mean irisin level in the patient group decreased as the severity of CKD increased (stage 2: 22.1±6.3 ng/mL; stage 3: 17.5±3.4 ng/mL; stage 4: 12.9±3.2 ng/mL; p<0.001). There was a positive correlation between the serum irisin level and the glomerular filtration rate (r=0.625, p<0.001). In the regression analysis CKD stage was an independent predictor of the irisin level (β ± SE= -4.663±0.511, p<0.001). CONCLUSION:In the CKD patients the serum irisin level decreased as the severity of disease increased. Accordingly, the catabolic process, which occurs more frequently in the advanced stages of CKD, might also play a role in decreasing the serum irisin level. KEy wORDS:Energy expenditure, Irisin, Chronic kidney disease Öz AMAÇ: Kronik böbrek yetmezliği (KBY) hastaları enerji tüketiminde artış, protein kaybı ve katabolik sürecin ön planda olduğu bir metabolizmaya sahiptirler. İrisin enerji harcamasına neden olan ve son zamanlarda keşfedilen termojenik bir proteindir. Biz KBY hastalarında irisin düzeyinin değişebileceğini ve bu durumun da KBY'deki enerji harcamasına katkıda bulunabileceğini düşünüyoruz. Çalışmada KBY hastalarında serum irisin düzeyini belirlemeyi ve irisin düzeyi ile KBY evresi arasındaki ilişkiyi incelemeyi amaçladık. GEREÇ ve yÖNTEMLER:Çalışmaya 90 KBY hastası (evre 2 -4) ve 32 sağlıklı kontrol dahil edildi. Katılımcıların rutin laboratuvar parametreleri ve serum irisin düzeyleri çalışıldı. Serum irisin düzeyi ELIZA kiti ile çalışıldı.BULGULAR: Serum irisin düzeyi tüm kronik böbrek hastalığı grubunda kontrol grubuna kıyasla daha düşük saptandı (p<0,05). Kronik böbrek hastalığında hastalık evresi arttıkça ortalama serum irisin düzeyinin azaldığı görüldü (evre 2:22,1±6,3; evre 3: 17,5±3,4; evre 4: 12,9±3,2; p<0,001). İrisin düzeyi ile glomerüler filtrasyon hızı arasında (r:0,625, p<0,001) pozitif yönde bir korelasyon saptandı. Regresyon analizinde KBY evresi irisin düzeyi için bağımsız prediktör olarak saptandı (β±SE= -4,663±0,511, p<0,001). SONUÇ:Kronik böbrek hastalığında hastalık evresi arttıkça serum irisin düzeyinin azalma saptandı. Bu sonuç, ile...

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Diet quality is associated with circulating C-reactive protein but not irisin levels in humans

Cited by 78 publications

References 55 publications

Factors associated with increased irisin levels in the type 1 diabetes mellitus

Factors associated with increased irisin levels in the type 1 diabetes mellitus

Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients

The Serum Irisin Level in Non-Diabetic Patients with Chronic Kidney Disease

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