Diet, Microbiota, Obesity, and NAFLD: A Dangerous Quartet

Machado, Mariana Verdelho; Cortez‐Pinto, Helena

doi:10.3390/ijms17040481

Cited by 101 publications

(74 citation statements)

References 150 publications

(202 reference statements)

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“…Probiotic supplementation is related to decreases in body weight and hepatic lipid contents [25,38]. NAFLD is caused by the synthesis of triglycerides and cholesterol in the liver due to prolonged high fat intake [39,40].…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus Brevis OPK-3 from Kimchi Prevents Obesity and Modulates the Expression of Adipogenic and Pro-Inflammatory Genes in Adipose Tissue of Diet-Induced Obese Mice

Park

Cha

2020

Nutrients

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Our previous study reported that lactic acid bacteria (L. brevis OPK-3) isolated from kimchi ameliorated intracellular lipid accumulation in 3T3-L1 adipocyte. The current study explored potential roles of L. brevis OPK-3 (KLAB) on preventing body weight gain and its effect on the inflammatory response of adipose tissue. Male C57BL/6 mice (n = 10) were divided into four groups: normal diet with distilled water (NDC), high-fat diet with distilled water (HDC), high-fat diet with L-ornithine (OTC) or high-fat diet with KLAB. The KLAB supplement resulted in significantly lower body weight, lower epididymal fat tissue mass, and lower serum and hepatic TG levels than the HDC. KLAB supplementation improved serum cytokines, and real-time polymerase chain reaction (PCR) analysis showed significantly lower inflammatory cytokine mRNA levels in epididymal adipose tissue. These results suggest that the administration of KLAB inhibits the induction of inflammation in adipose tissue along with the inhibition of weight gain. Therefore, this study demonstrates the therapeutic and beneficial value of this strain produced during the fermentation of kimchi.

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Section: Discussionmentioning

confidence: 99%

Lactobacillus Brevis OPK-3 from Kimchi Prevents Obesity and Modulates the Expression of Adipogenic and Pro-Inflammatory Genes in Adipose Tissue of Diet-Induced Obese Mice

Park

Cha

2020

Nutrients

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“…Nonalcoholic fatty liver disease (NAFLD) refers to the accumulation of fat in the liver (1) and occurs due to metabolic dysfunction associated with energy surplus-induced adiposopathy (2). It is the most common cause of chronic liver disease in Western countries (3) and is not confined to liver related morbidity and mortality.…”

Section: Importance Of the Microbiome In Liver Diseasementioning

confidence: 99%

Gut microbiome and liver disease

Betrapally

Gillevet

Bajaj

2017

Translational Research

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Gut microbiota changes are important in determining the occurrence and progression of chronic liver disease related to alcohol, non-alcoholic fatty liver disease and cirrhosis. Specifically the systemic inflammation, endotoxemia and the vasodilation that leads to complications such as spontaneous bacterial peritonitis and hepatic encephalopathy could be related to the gut milieu. Given the poor prognosis of these events, their prevention and early management are essential. Microbiota may be essential component of the gut milieu that can impact these clinical events and the study of their composition and function in a culture-independent manner could help understand the prognosis. Recent human and animal studies have shown that the relative abundance and the functional changes of microbiota in the stool, colonic mucosa and saliva have varying consequences on the presence and prognosis of chronic liver disease and cirrhosis. The impact of therapies on the microbiota is slowly being understood and will likely lead to a more targeted approach to gut microbiota modification in chronic liver disease and cirrhosis.

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“…Obesity is closely associated with the development of numerous comorbid conditions, including insulin resistance (IR) and type 2 diabetes (T2D), and it serves as an important trigger for a variety of devastating diseases (e.g., nonalcoholic fatty liver disease, cardiovascular diseases, several cancers) . In patients with obesity, these metabolic maladjustments are accompanied by IR, which may underlie the links between obesity and chronic metabolic disorders.…”

Section: Introductionmentioning

confidence: 99%