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Cited by 12 publications
(8 citation statements)
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References 29 publications
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“…These conclusions are supported by the data indicating that induction of diabetes using a high dose of STZ caused profound damage to the aortic wall layers, tunica intima and tunica media, which was prevented following daily administration of insulin for 8 weeks (Figure 1). Furthermore, insulin significantly reduced circulating biomarkers of inflammation (TNF- and hs-CRP), vascular injury (sVCAM-1 and sICAM-1), oxidative stress (MDA), and hyperlipidemia (Figures 2 -4) that are known to be elevated in cardiovascular disease secondary to diabetes (Dai et al, 2016, Berk et al, 2016, Rodriguez-Castaneda et al, 2018 these references maybe mentioned before].…”
Section: Discussionmentioning
confidence: 99%
“…These conclusions are supported by the data indicating that induction of diabetes using a high dose of STZ caused profound damage to the aortic wall layers, tunica intima and tunica media, which was prevented following daily administration of insulin for 8 weeks (Figure 1). Furthermore, insulin significantly reduced circulating biomarkers of inflammation (TNF- and hs-CRP), vascular injury (sVCAM-1 and sICAM-1), oxidative stress (MDA), and hyperlipidemia (Figures 2 -4) that are known to be elevated in cardiovascular disease secondary to diabetes (Dai et al, 2016, Berk et al, 2016, Rodriguez-Castaneda et al, 2018 these references maybe mentioned before].…”
Section: Discussionmentioning
confidence: 99%
“…Thereafter, energy intake was slowly increased up to approximately 5500 kJ (1300 kcal) per day (a low-energy diet) over 12 weeks. Some of the baseline characteristics and effect of the diet on body weight in cohort 1 have previously been reported [ 25 ].…”
Section: Methodsmentioning
confidence: 99%
“…This indicates a fundamental stage in responding to vascular injury and the formation of a fibrous cap with the increased extracellular matrix, causing the thickening of the intima and the subsequent formation of atherosclerotic plaque [14]. Despite all these, endothelial dysfunction associated with atherosclerosis can be minimized through physical activities and changes in lifestyle for weight loss with minimal adipose tissue-related inflammation and increased NO availability [96].…”
Section: Molecular Mechanisms Linked To the Progression Of Atherosclementioning
confidence: 99%