Diet-induced gut dysbiosis and inflammation: Key drivers of obesity-driven NASH

Kang, Gideon G.; Trevaskis, Natalie L.; Murphy, Andrew; Febbraio, Mark A.

doi:10.1016/j.isci.2022.105905

Cited by 24 publications

(12 citation statements)

References 250 publications

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“…The Shakurnia et al study showed that sugarcane molasses augments both the anti-inflammatory and pro-inflammatory cytokines by PBMCs of UC patients (11). Other evidence indicates that the inflammatory responses of mononuclear cells to sugarcane molasses may be due to the high sugar concentration in molasses (11,15,25). The Shakurnia et al study showed that sugarcane molasses caused a significant increase in TGF-β compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

“…Their results showed that sugarcane molasses added to B. lactis augments the secretion of TGF-β, the anti-inflammatory cytokine, by peripheral blood mononuclear cells (PBMCs) but does not decrease the level of TNF-α, the pro-inflammatory cytokine. Based on studies (15), the 30 -40% sugar in the sugarcane molasses may be a trigger for inflammation.…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Immunomodulatory Effects of Sugar-Free Sugarcane Molasses and Bifidobacterium animalis subsp. lactis on IFN-γ and TGF-β Secretion in Ulcerative Colitis Patients

Khalaf Shamsabadi,

Mirzaee,

Baharifar

et al. 2024

J Adv Immunopharmacol

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Background: Ulcerative colitis (UC) is an inflammatory bowel disease that leads to gastrointestinal ulcers. An overactive immune response against the intestinal microbiota has been suggested as one of the pathogenic factors. Some evidence indicates the immunomodulatory effects of Bifidobacterium lactis. sugarcane molasses, rich in vitamins and nutrients, can be used to compensate for the related nutrient deficiencies. Objectives: This study aims to evaluate the effects of sugar-free sugarcane (SFS)-molasses on the immune system of UC patients. Methods: Bifidobacterium lactis was cultivated in MRS broth and killed by UV de-sugarization of sugarcane molasses. It was prepared using the Steffen method. Peripheral blood mononuclear cells (PBMCs) of 12 UC patients were separated by Ficoll-Hypaque centrifugation. Peripheral blood mononuclear cells, SFS-molasses, and B. lactis were co-cultured. After 18h, the expression level of the FOXP3 gene was assessed by RT-qPCR (real-time PCR). The interferon gamma (IFN-γ) and transforming growth factor beta (TGF-β) were measured in the supernatant of PBMCs by ELISA. Results: Transforming growth factor beta in the SFS-molasses group was significantly increased compared to the controls (P = 0.032). The TGF-β in SFS-molasses + bacteria and the bacteria-alone groups increased compared to the control group (P = 0.039 and P = 0.049, respectively). The level of IFN-γ in the SFS-molasses group was significantly decreased compared to the controls (P = 0.004). Interferon gamma increased in the SFS-molasses + B. lactis group compared to the controls, but this was not significant. Expression of FOXP3 wasn’t affected after SFS-molasses treatment. Conclusions: These data showed that SFS molasses increases the levels of anti-inflammatory cytokine TGF-β and decreases the pro-inflammatory cytokine IFN-γ levels. These results may encourage researchers to continue studying the possible application of molasses as a nutritious food for patients with UC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In Vitro Immunomodulatory Effects of Sugar-Free Sugarcane Molasses and Bifidobacterium animalis subsp. lactis on IFN-γ and TGF-β Secretion in Ulcerative Colitis Patients

Khalaf Shamsabadi,

Mirzaee,

Baharifar

et al. 2024

J Adv Immunopharmacol

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“…Diet-induced obesity and related conditions, such as hepatic steatosis, simple steatohepatitis, and chronic low-grade inflammation are major health concerns worldwide. 1,33 It is generally accepted that HFD typically leads to lipid accumulation and elevation of pro-inflammatory factors in the liver, with specific forms of steatosis and steatohepatitis. 34,35 FBT has been extensively studied in recent decades for its beneficial effects on obesity and related diseases, and it has been convincingly demonstrated as a potentially beneficial adjuvant.…”

Section: Discussionmentioning

confidence: 99%

“…High-fat diet (HFD)-induced obesity and associated conditions such as hepatic steatosis and steatohepatitis have become public health problems of global concern. 1 Obesity is a major factor or complication of hepatic steatosis and its progression to steatohepatitis, which are caused by impaired insulin activity, overflow of portal triglycerides, and production of inflammatory cytokines in metabolic dysfunction conditions. 2 Therefore, researchers and scientific societies have proposed to change the terminology of hepatic steatosis or steatohepatitis to metabolic-associated fatty liver disease.…”

Section: Introductionmentioning

confidence: 99%

Fuzhuan brick tea ameliorates hepatic steatosis and steatohepatitis through gut microbiota-derived aryl hydrocarbon receptor ligands in high-fat diet-induced obese mice

Liu,

Wang,

Liu

et al. 2023

Food Funct.

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“…La disbiosis intestinal puede alterar la producción y absorción de SCFA dando una alta concentración de SCFA en las heces. Blautia y Prevotella copri se correlacionan positivamente con el butirato y el propionato fecal (Kang et al, 2022).…”

Section: Mecanismos Implicados En La Relación De La Disbiosis Intesti...unclassified

Implicación de la disbiosis intestinal en la obesidad.

Machado-Fernandez,

Mora-Domínguez,

Peña-Cordero

2023

MQRInvestigar

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La microbiota intestinal regula muchos procesos fisiológicos a través de interacciones con el huésped, como la digestión de los alimentos, la absorción y el metabolismo de nutrientes, la síntesis de vitaminas y ácidos biliares, así como prevención de la propagación de microorganismos patógenos e incluso regulación de la expresión inmunológica y génica del huésped. La alteración de estos procesos a causa de la disbiosis intestinal podría estar implicado en la fisiopatología de la Obesidad. El equilibro entre la proporción Firmicutes / Bacteroidetes y una baja cantidad de Proteobacteria se ha asociado con una microbiota intestinal saludable. Prevotella,Veillonella, Blautia , Lachnoclostridium, Estreptococo, Faecalitalea, Desulfovibrio, Escherichia. Proteus. Shiguella y Fusobacterium se asociaron a la obesidad. Los estudios han revelado como causas de disbiosis intestinal a diversos factores ambientales como el exceso consumo de alimentos grasos y azucares o la exposición a factores estresantes, sin embargo también existe un importante componente genético hereditario que predispone en el desarrollo del microbioma intestinal, llegando a la conclusión que la disbiosis intestinal podría ser una huella tanto del medio ambiente como del material genético hereditario y predisponer a generaciones futuras a estas alteraciones metabólicas. Los microbianos asociados a la reducción de peso pueden tener potencial terapéutico para la obesidad y las enfermedades metabólicas entre los cuales tenemos A. muciniphila, las, Alistipes, Bifidobacterium, Faecalibacterium y Roseburia. La evaluación de biomarcadores universales de la microbiota intestinal en obesidad se puede aplicar para la predicción temprana y los objetivos potenciales para los tratamientos adyuvantes de la obesidad.

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Diet-induced gut dysbiosis and inflammation: Key drivers of obesity-driven NASH

Cited by 24 publications

References 250 publications

In Vitro Immunomodulatory Effects of Sugar-Free Sugarcane Molasses and Bifidobacterium animalis subsp. lactis on IFN-γ and TGF-β Secretion in Ulcerative Colitis Patients

In Vitro Immunomodulatory Effects of Sugar-Free Sugarcane Molasses and Bifidobacterium animalis subsp. lactis on IFN-γ and TGF-β Secretion in Ulcerative Colitis Patients

Fuzhuan brick tea ameliorates hepatic steatosis and steatohepatitis through gut microbiota-derived aryl hydrocarbon receptor ligands in high-fat diet-induced obese mice

Implicación de la disbiosis intestinal en la obesidad.

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