Diet First, Then Medication for Hypercholesterolemia

Abstract

Long-term survival and competing causes of death in patients with early-stage Hodgkin's disease treated at age 50 or younger.

Effect of combining viscous fibre with lovastatin on serum lipids in normal human subjects

“…Similar findings were observed in trial reported by Moreyra et al. Concomitant psyllium and statin therapy achieved LDL reductions equivalent to doubling the dose of the drug (22,23) and similar can be interpreted from our study. Thus, psyllium augments the cholesterol‐lowering effect of statin therapy and will permit the use of lower dose of statins.…”

Aqueous Extract of Indian Costus Roots Effects on a Diet-Induced Hypercholesterolemia in Murine Model.

“…Colca (2006) reported that the increased of HDL levels after costus.speciosus ethanolic extract administration, might be due to the increase in the activity of lecithin cholesterol acyl transferase, which may contribute to the regulation of blood lipids. In addition, the reduced of the triglycerides in the blood might be due to the activity of lipoprotein lipase (LPL) which decrease of synthesis of triglycerides in the liver (Anderson 2003).Our results were in agreement with the result of Revathy et al, (2014) In our study, the significant increases in AST, ALT, and ALP levels by untreated hypercholesterolemic mice might be induced due to liver dysfunction. This results agree with studies were reported that high cholesterol diet resulted increase of liver enzyme levels (Nanji et al, 1997).…”

Hypocholesterolaemic effects of soya proteins: results of recent studies are predictable from the Anderson meta-analysis data

“…The meta-analysis was based on a wide variety of studies, some with a total substitution of dietary proteins, others with only a partial substitution, whereas all the recent studies involved partial substitutions/additions. This observation clearly suggests that the beneficial effects of soya proteins are probably not consequent on gross dietary changes, for example in lipid composition, fibre or other substances, as suggested by some authors (Lichtenstein et al 2002; Sacks et al 2006), but most likely depend on some components that elicit a ‘pharmacological effect’ on the LDL-receptor system (Anderson, 2003). This conclusion would thus be no different from that relating to the hypotensive activity of milk peptides, antagonists of the angiotensin-converting enzyme system (Vermeirssen et al 2004), and clearly effective only in hypertensive individuals.…”

“…Table 2. Comparison of the net changes in total and LDL-cholesterol concentrations in early and recent studies according to quartiles of the study group for initial plasma cholesterol levels in the Anderson meta-analysis (Anderson et al 1995) Anderson meta-analysis: characteristics of quartiles and changes in total and LDL-cholesterol Q1 Q2 Q3 Q4 are probably not consequent on gross dietary changes, for example in lipid composition, fibre or other substances, as suggested by some authors (Lichtenstein et al 2002;Sacks et al 2006), but most likely depend on some components that elicit a 'pharmacological effect' on the LDL-receptor system (Anderson, 2003). This conclusion would thus be no different from that relating to the hypotensive activity of milk peptides, antagonists of the angiotensin-converting enzyme system (Vermeirssen et al 2004), and clearly effective only in hypertensive individuals.…”