Diet and the epigenome

Abstract

Over the past decade, remarkable breakthroughs in our understanding of epigenetic biology have coincided with an increased public interest in the impact of diet and lifestyle choices on health. It is well established that a balanced diet enhances life expectancy and helps to prevent or treat certain diseases, such as obesity, diabetes, cancer, and mental disorders. However, the biological mechanisms underlying these effects are not yet well understood. In this commentary, we highlight several recent studies that report on a potential link between dietary factors and alterations in epigenetic pathways, providing compelling insight into the possible effects of environmental factors on fundamental biological processes.

The Multifaceted Reactivity of Single‐Atom Heterogeneous Catalysts

“…[10] Aided by synthetic and analytical advancements,ahuge range of potential host materials has now been reported (Figure 2), which encompasses metal oxides, [11][12][13][14] metal hydroxides, [15,16] metals (also termed single-atom alloys (SAAs)), [17,18] micro/ mesoporous materials such as zeolites, [19,20] metal-organic frameworks (MOFs), [21,22] silicas, [23,24] carbon-based materials, [25][26][27][28] organopolymers, [29,30] nitrides, [31][32][33] and carbides. [10] Aided by synthetic and analytical advancements,ahuge range of potential host materials has now been reported (Figure 2), which encompasses metal oxides, [11][12][13][14] metal hydroxides, [15,16] metals (also termed single-atom alloys (SAAs)), [17,18] micro/ mesoporous materials such as zeolites, [19,20] metal-organic frameworks (MOFs), [21,22] silicas, [23,24] carbon-based materials, [25][26][27]…”

“…One of the first challenges in the development of SACs was how to stabilize metal atoms against sintering or leaching in sufficient amounts to give appreciable activity.M etalcontaining zeolites and zeotypes,inwhich metal centers were mainly isolated in crystallographic positions,were among the most notable early examples of successful SACs. [10] Aided by synthetic and analytical advancements,ahuge range of potential host materials has now been reported ( Figure 2), which encompasses metal oxides, [11][12][13][14] metal hydroxides, [15,16] metals (also termed single-atom alloys (SAAs)), [17,18] micro/ mesoporous materials such as zeolites, [19,20] metal-organic frameworks (MOFs), [21,22] silicas, [23,24] carbon-based materials, [25][26][27][28] organopolymers, [29,30] nitrides, [31][32][33] and carbides. [34] Further extending the diversity of this framework with host functionalization strategies (such as,t hrough partial surface hydration, [35] introduction of alkali metals, [36] or decoration with ethylene glycolate species [37] )h as also been demonstrated to successfully enhance the anchoring of metal atoms.…”

Neuroprotective Effects of Choline and Other Methyl Donors

“…Studies have shown that dietary components interact with our epigenome and could have long-lasting effects [70,71]. In this section, we will present the beneficial effects of the supplementation of choline during early development on brain cognitive functions later in life.…”

“…Dietary components intake during early life could exert long-lasting effects on mental health [70] as the brain during early development is plastic and undergoes rapid growth and differentiation for its normal functioning. One carbon metabolism is influenced by nutritional status [72].…”

IRIS: Big data-informed discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing

“…Various types of dysregulation at the RNA level can generate immunogenic peptides in cancer cells [13][14][15] . Notably, tumors harbor up to 30% more alternative splicing (AS) events than normal tissues, and the resulting peptides are predicted to be presented by human leukocyte antigen (HLA) 16 .…”