Diet and ovarian cancer risk: An umbrella review of systematic reviews and meta-analyses of cohort studies

Sun, Hui; Gong, Ting-Ting; Yang, Xia; Wen, Zhao-Yan; Zhao, Longgang; Zhao, Yuhong; Wu, Qi‐Jun

doi:10.1016/j.clnu.2020.11.032

Cited by 25 publications

(28 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A meta-analysis including 15 observational studies also showed a significant inverse relationship between calcium intake and breast cancer incidence, although the effect size became smaller after the publication bias was corrected 57 . As for other types of cancer, weak negative associations between dietary calcium intake and the risk for ovarian cancer and astrocytic glioma were reported previously 58,59 . Interestingly, some studies detected positive associations between calcium intake and the risk for certain types of cancer.…”

Section: Cancermentioning

confidence: 82%

See 1 more Smart Citation

Health Effects of Calcium: Evidence From Mendelian Randomization Studies

et al. 2021

View full text Add to dashboard Cite

Calcium is widely used in conjunction with vitamin D to prevent osteoporosis. The use of calcium supplementation is also promoted for its potential benefits in lowering the risk for metabolic syndromes and cancers. However, the causal link between calcium and various health outcomes remains unclear. This review focuses on the evidence from twenty-four Mendelian randomization studies that were designed to minimize bias from confounding and reverse causation. These MR studies evaluated the effect of lifelong genetically higher serum calcium levels on various health outcomes. Overall, available MR studies found no conclusive effects of serum calcium levels on bone mineral density and fracture, ischemic stroke and heart failure, cancers, type 2 diabetes, Parkinson's disease, and offspring birth weight. However, a higher serum calcium concentration was reported to have estimated causal effects on increased risks for coronary artery disease (especially myocardial infarction), migraine, renal colic, allergy/adverse This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as

show abstract

Section: Cancermentioning

confidence: 82%

“…( 57 ) As for other types of cancer, weak negative associations between dietary calcium intake and the risk for ovarian cancer and astrocytic glioma were reported. ( 58 , 59 )…”

Section: Introductionmentioning

confidence: 99%

Health Effects of Calcium: Evidence From Mendelian Randomization Studies

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Patients with risk factors such as diabetes mellitus are reportedly at a notably high risk for OC, and interventions such as metformin use dramatically reduce OC incidence (14). A systematic review suggested that OC risk was inversely associated with intake of black tea or calcium, and positively associated with intake of skim/low-fat milk or lactose (15). Such findings imply the necessity of comprehensive and comparable assessments of risk factors attributable to OC, which could then help in the development of prevention and treatment strategies.…”

Section: Introductionmentioning

confidence: 99%

Disease Burden and Attributable Risk Factors of Ovarian Cancer From 1990 to 2017: Findings From the Global Burden of Disease Study 2017

Zhou

Wang

Ren

et al. 2021

Front. Public Health

View full text Add to dashboard Cite

Aim: We aimed to estimate the disease burden and risk factors attributable to ovarian cancer, and epidemiological trends at global, regional, and national levels.Methods: We described ovarian cancer data on incidence, mortality, and disability-adjusted life-years as well as age-standardized rates from 1990 to 2017 from the Global Health Data Exchange database. We also estimated the risk factors attributable to ovarian cancer deaths and disability-adjusted life-years. Measures were stratified by region, country, age, and socio-demographic index. The estimated annual percentage changes and age-standardized rates were calculated to evaluate temporal trends.Results: Globally, ovarian cancer incident, death cases, and disability-adjusted life-years increased by 88.01, 84.20, and 78.00%, respectively. However, all the corresponding age-standardized rates showed downward trends with an estimated annual percentage change of −0.10 (−0.03 to 0.16), −0.33 (−0.38 to −0.27), and −0.38 (−0.32 to 0.25), respectively. South and East Asia and Western Europe carried the heaviest disease burden. The highest incidence, deaths, and disability-adjusted life-years were mainly in people aged 50–69 years from 1990 to 2017. High fasting plasma glucose level was the greatest contributor in age-standardized disability-adjusted life-years rate globally as well as in all socio-demographic index quintiles and most Global Disease Burden regions. Other important factors were high body mass index and occupational exposure to asbestos.Conclusion: Our study provides valuable information on patterns and trends of disease burden and risk factors attributable to ovarian cancer across age, socio-demographic index, region, and country, which may help improve the rational allocation of health resources as well as inform health policies.

show abstract

“…However, dairy products constitute a key part of the daily diet. It is possible that the intake of dairy products may not change before and after diagnosis because recent studies have provided limited or weak evidence of the potential effect of dairy products on OC (22). Third, we failed to examine whether associations with OC prognosis and dairy product type differed by subtype, such as skim/low-fat milk, cheese, and yogurt, due to lower intakes of these dairy products in the present study as well as in China (23).…”

Section: Discussionmentioning

confidence: 61%

Pre-diagnosis Dairy Product Intake and Ovarian Cancer Mortality: Results From the Ovarian Cancer Follow-Up Study (OOPS)

et al. 2021

Self Cite

View full text Add to dashboard Cite

Background: Dairy product consumption is associated with ovarian cancer (OC) incidence. However, limited evidence is available on its influence on OC mortality.Methods: The association between pre-diagnostic dairy product intake and OC mortality was investigated in the OC follow-up study, which included a hospital-based cohort (n = 853) of women diagnosed with epithelial OC between 2015 and 2020. Pre-diagnosis diet information was collected using a validated food frequency questionnaire. Deaths were ascertained up to March 31, 2021 via death registry linkage. Cox proportional hazards model was used to estimate the adjusted hazard ratio (HR) and 95% confidence interval (CI) for the aforementioned association.Results: A total of 130 women died during the median follow-up of 37.2 months (interquartile: 24.7–50.2 months). Comparisons of highest to lowest tertile intake showed that pre-diagnosis dairy product use was associated with total OC mortality (HR = 2.03, 95% CI = 1.21–3.40, p trend = 0.06). In addition, short survival was separately associated with protein (HR = 2.09, 95% CI = 1.25–3.49, p trend < 0.05), fat (HR = 2.16, 95% CI = 1.30–3.61, p trend < 0.05), and calcium (HR = 2.03, 95% CI = 1.21–3.4, p trend = 0.06) from dairy intake. Similar positive magnitudes were observed for menopausal status, residual lesions, histological type, and body mass index, although not all of these factors showed statistical significance.Conclusion: Pre-diagnosis dairy product consumption, including protein, fat, and calcium from dairy intake, was associated with higher mortality among OC survivors.

show abstract

Diet and ovarian cancer risk: An umbrella review of systematic reviews and meta-analyses of cohort studies

Cited by 25 publications

References 60 publications

Health Effects of Calcium: Evidence From Mendelian Randomization Studies

Health Effects of Calcium: Evidence From Mendelian Randomization Studies

Disease Burden and Attributable Risk Factors of Ovarian Cancer From 1990 to 2017: Findings From the Global Burden of Disease Study 2017

Pre-diagnosis Dairy Product Intake and Ovarian Cancer Mortality: Results From the Ovarian Cancer Follow-Up Study (OOPS)

Contact Info

Product

Resources

About