Diet and men's fertility: does diet affect sperm quality?

Nassan, Feiby L.; Chavarro, Jorge E.; Tanrikut, Cigdem

doi:10.1016/j.fertnstert.2018.05.025

Cited by 116 publications

(114 citation statements)

References 134 publications

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“…Our hypothesis that the use of the salmon oil would influence the semen quality parameters was confirmed by the improved motility, increased percentage of live spermatozoa and elevation of the serum testosterone level. These results are in line with those described by other authors (González‐Ravina et al, ; Nassan, Chavarro, & Tanrikut, ; Risso et al, ; Rocha et al, ; Santos, Souza, Quirino, Bastos, & Cunha, ).…”

Section: Discussionsupporting

confidence: 93%

“…increased percentage of live spermatozoa and elevation of the serum testosterone level. These results are in line with those described by other authors(González-Ravina et al, 2018;Nassan, Chavarro, & Tanrikut, 2018;Risso et al, 2015;Rocha et al, 2009;Santos, Souza, Quirino, Bastos, & Cunha, 2016).The improving of sperm quality can be associated with changes in phospholipid profile of the spermatozoa due to ingestion of a substance rich in EPA and DHA (salmon oil) (González-Ravina et al, 2018). Although the transformation of spermatogonia into mature spermatozoa involves a large number of complex steps, the focus on some important changes can facilitate discussion of how nutritional supplementation affects this complex process.…”

supporting

confidence: 88%

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Residual effect after salmon oil supplementation on semen quality and serum levels of testosterone in dogs

Santos

Milani

Zucchini

et al. 2019

Reprod Domestic Animals

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The objective of present study was to evaluate the effects of oral supplementation of salmon oil on seminal parameters and testosterone serum levels in dogs, following also the residual effects for 60 days after treatment. Nine healthy male dogs with proven fertility, weighing between 10 and 36 kg, ageing from 2 to 11 years, of different breeds, fed diets supplemented with salmon oil at the manufacturer's recommended dosage. The parameters measured were sperm volume, motility, vigour, normal morphology and concentration, live/dead ratio, membrane viability by means of HOST test and serum testosterone levels. Evaluations occurred at baseline (D0), after 90 days of supplementation (D90) and at the end of the experiment, 60 days after supplementation cessation (D150). Results (mean ± SD) obtained at time D0, D90 and D150 were as follows: motility of 76.66% ± 13.7, 92.77 ± 4.41 and 93.0 ± 7.90 (p = .001); normal spermatozoa of 69.11% ± 24.90, 90.00% ± 5.15 and 80.66 ± 16.04 (p = .05); live/dead (%) from 64.44 ± 22.86 to 85.33 ± 8.41 (p = .001); and spermatozoa (%) with integral membrane in the membrane integrity (HOST) test ranging from 76.44 ± 20.74 to 91.22 ± 4.68 (p = .05). Serum levels of testosterone (ng/ml) increased from 5.50 ± 1.13 to 8.84 ± 1.13 at D90 (p = .003) and decreased after 2 months (D150) to 5.13 ± 1.13. In conclusion, a 90‐day supplementation with salmon oil had a positive influence on semen quality and serum testosterone levels. The supplementation of omegas 3 and 6 at the ratio of 10:1 for 90 days determined an increase in concentration and motility of the sperm, and these effects were maintained for 60 days, with the only exception of testosterone levels.

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Section: Discussionsupporting

confidence: 93%

supporting

confidence: 88%

Residual effect after salmon oil supplementation on semen quality and serum levels of testosterone in dogs

Santos

Milani

Zucchini

et al. 2019

Reprod Domestic Animals

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“…This is reflected in the questions reported by patients in our study, with a special interest on the impact of diet on infertility and its treatment (ranked third). Although recent published studies about diet and fertility (Chiu, Chavarro et al 2018;Nassan, Chavarro et al 2018) and different diet patterns and IVF outcomes indicate a keen interest in this topic (Karayiannis, Kontogianni et al 2018;Sugawa, Okubo et al 2018), in our survey the relative importance of diet appears unexpectedly high. This could be due to the relatively low difficulty in modifying this factor, for example by introducing food supplements or so called "superfoods", in comparison to other lifestyle changes more difficult to maintain, such as changing unhealthy habits or introducing regular physical activity in one's routine.…”

Section: Discussionmentioning

confidence: 60%

Identification of Research Priorities in Infertility and Assisted Reproduction: An International, Multicenter Study in Partnership with Patients

García¹,

Lidenberg²,

Hagström-Toft³

et al. 2019

Preprint

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STUDY QUESTION: Which are the main research interests among patients of assisted reproductive technologies (ART)?SUMMARY ANSWER: Patients identified as research priorities that deserve further investigation: success rates and risks of ART, side-effects of treatments, resources to cope with infertility, effectiveness of alternative therapies, lifestyle habits to protect fertility, oocyte quality and ovarian reserve, and causes of genetic or hereditary infertility.WHAT IS KNOWN ALREADY: The involvement of patients and caregivers in setting research agendas in medicine has gathered significant momentum in the last decade. Patients’ involvement in setting research priorities offers several benefits: improved patient knowledge and awareness of their condition; greater understanding of the medical professionals of the impact of the condition on patients’ quality of life; reduced costs associated with redundant research activities. This is may be also applicable to research in infertility and ART, where patients’ interests have never been explored before.STUDY DESIGN, SIZE, DURATION: This is a cross-sectional study that consists of an anonymous online survey, which was sent up to three times to 2112 patients from 11 fertility centers in 5 countries between January-December 2018. The study design was based on the James Lind Alliance priority setting partnership model, which comprises the identification of patients groups, the exploration of the research agenda, the analysis of collected data and identification of priorities.PARTICIPANTS/MATERIALS, SETTING, METHODS: Overall, 2112 patients were contacted, and 945 surveys were answered (RR: 44.7%). Patients were asked to identify research questions relevant to them in the areas of infertility causes and prevention, fertility treatments (medication and ART), and the emotional aspects of infertility. Answers were categorized in topics and ranked by frequency. A long list of the top-30 research topics was extracted from the aggregate results, from which, a short list of the top-10 research topics was created. At the end, 10 research questions related to each of the 10 research topics were constructed, based on the answers given by patients.MAIN RESULTS AND THE ROLE OF CHANCE: Female (845, 89.4%) and male (100, 10.6%) patients were included. The mean age of patients was 37.8 (SD 1.74). Most of the patients did not have children at the time of the survey (523, 59%), while 51 (5.7%) were pregnant. Sixty (6.3%) patients did not start treatment, 579 (61.3%) were performing a treatment with their own gametes and 304 (32.2%) were treated through gamete donation. Patients were mainly interested in the effectiveness of ART -especially per clinical profile-, side effects of drugs, protection of fertility and prevention of infertility –especially through diet and exercise-, and psychological aspects of the infertility journey. The top-10 research questions (and weight) obtained were: 1) What are the side-effects of ART treatments? (41.6%); 2) What are the most effective methods to cope with infertility from the psychological point of view? (37.2%); 3) What effects could diet have on fertility? (25.9%); 4) What are ART success rates per clinical profile? (25.9%); 5) Are there habits and lifestyle factors that could prevent infertility? (20.0%); 6) What are the long-term risks associated to ART? (18.5%); 7) Are alternative therapies such as acupuncture, yoga, and meditation effective to treat/prevent infertility? (18.5%); 8) What is the impact of exercise on fertility? (15.4%); 9) How does oocytes quantity and quality affect fertility? (9.5%); 10) What are the genetic patterns or hereditary conditions causing/related to infertility? (9.5%).LIMITATIONS, REASONS FOR CAUTION: Although all respondents had attended a fertility center, not all of them were diagnosed as infertile (i.e. single women) and had started treatment at the time of response, while a few were pregnant; their priorities for research might have been influenced by their infertility journey. Also, all participants attended private fertility centers: areas of interest may be different in public settings.WIDER IMPLICATIONS FOR THE FINDINGS: Researchers and clinicians should keep in mind that, in addition to improvement of treatments’ success rates and side-effects, patients greatly value research on causes, prevention and emotional aspects of infertility. As their views might differ from those of medical professionals, patients’ voices should be incorporated in setting infertility research priorities.

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“…Abbreviations: iAT, idiopathic astenoteratozoospermia; iOAT, idiopathic oligo-astheno-tretozoospermia; OAT, oligo-astheno-tretozoospermia. (Collins & Rossi, 2015;Nassan, Chavarro, & Tanrikut, 2018). Although few clinical trial studies have been conducted in these areas, the results of the present study indicate that diet status has a correlation with sperm motility in the semen sample (Salas-Huetos, James, Aston, Jenkins, & Carrell, 2019).…”

Section: Sperm Motility Molecular Pathways and Lifestylementioning

confidence: 55%

“…(Collins & Rossi, 2015;Nassan, Chavarro, & Tanrikut, 2018 (Collins & Rossi, 2015;Nassan, Chavarro, & Tanrikut, 2018 …”

Section: Sperm Motility Molecular Pathways and Lifestylementioning

confidence: 99%

Asthenozoospermia: Cellular and molecular contributing factors and treatment strategies

et al. 2019

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| INTRODUC TI ONIn recent years, many researchers have focused on possible factors leading to male infertility and revealed the existence of many cellular and molecular defects during sperm production and maturation. These defects finally affect the count and structure of spermatozoa and reduce the ability of spermatozoa to reach and fertilise the egg. A decrease in sperm motility, called "asthenozoospermia," is one of these important deficiencies, which is influenced by various cellular and molecular factors. After a brief explanation of the main cellular and molecular factors involved in reducing sperm motility, this review article presents some important treatment strategies to overcome sperm motility reduction. | DEFINITI ON AND PRE VALEN CEAccording to the reports released by the World Health Organization (WHO), about 20% of couples are infertile and infertility can be, at least partly, attributed to the male partner (Petok, 2015). Low sperm count, abnormal morphology and poor sperm motility are the common causes related to male factors. Based on the WHO guideline (2010), asthenozoospermia was defined as total motility <40% and progressive motility <32% in a semen sample (WHO, 2010).Severe asthenozoospermia was also characterised by total sperm immobility or very low motile spermatozoa in the semen sample. It seems that total sperm immobility is related to genetic disorders (Blouin et al., 2000). This will be explained in more detail below.Understating the cellular and molecular processes leading to sperm motility is required to help the researchers to address the subject of reduced sperm motility and produce an accurate diagnosis (Turner, 2003).To diagnose asthenozoospermia in individuals in an andrology laboratory, some important points must be taken into consideration to prevent false asthenozoospermia diagnosis. For instance, semen should not be collected in long abstinence days since the number of immotile spermatozoa is high in abstinence days. Also, semen AbstractSemen sample with poor sperm motility, which called asthenozoospermia, is considered as one of the main factors contributing to male infertility. Recognition of the cellular and molecular pathways contributing to sperm motility reduction may lead to applying novel treatment strategies for overcoming low sperm motility in asthenozoospermia individuals. In this review, we intend to discuss the main causes of sperm motility reduction in asthenozoospermia and some treatment strategies used to overcome low sperm motility. K E Y W O R D Sapoptosis, reactive oxygen species, spermiogenesis

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Diet and men's fertility: does diet affect sperm quality?

Cited by 116 publications

References 134 publications

Residual effect after salmon oil supplementation on semen quality and serum levels of testosterone in dogs

Residual effect after salmon oil supplementation on semen quality and serum levels of testosterone in dogs

Identification of Research Priorities in Infertility and Assisted Reproduction: An International, Multicenter Study in Partnership with Patients

Asthenozoospermia: Cellular and molecular contributing factors and treatment strategies

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