Diet and cancer

Wicki, Andreas; Hagmann, Jörg

doi:10.4414/smw.2011.13250

Cited by 9 publications

(6 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The evidences are compelling that healthy diet supplemented with vitamins, antioxidants or other beneficial micronutrients has real influence in reducing cancer incidence and mortalities. It was estimated that one-third of all cancer cases could be prevented by a healthy diet [4,5].…”

Section: Natural Products As Anticancer Agentsmentioning

confidence: 99%

The Role of Natural Dietary Products in Nanomedicine

Rahman¹,

Othman²,

RasedeeAbdullah³

et al. 2019

Nanomedicines

View full text Add to dashboard Cite

It has long been established that a diet rich in fresh fruits, vegetables, seeds, grains and legumes and antioxidants, and other beneficial compounds may help prevent various human diseases. However, diet is not a cure for treatment of severe diseases, but it may help prevent some ailments, and it can help the body overcome the effects of conventional treatments. Natural compounds not only serve as a drug or template for drugs but also, in many instances, had been a source of discovery of novel biology that provided better understanding of target and pathway involved in the disease processes. In addition, drugs derived from natural compounds work better for patients than do drugs manufactured synthetically. Approximately, 40% of drugs in the pipeline and 70% of synthetic therapeutic molecules are plagued with poor solubility, oral bioavailability, and delivery. Drugs with poor solubility encounter limited transport during oral administration because of low concentration gradient between the gut and the blood vessels. To increase body fluid saturation solubility of poorly soluble drug, new delivery methods need to be developed using natural dietary plant metabolites.

show abstract

Section: Natural Products As Anticancer Agentsmentioning

confidence: 99%

The Role of Natural Dietary Products in Nanomedicine

Rahman¹,

Othman²,

RasedeeAbdullah³

et al. 2019

Nanomedicines

View full text Add to dashboard Cite

show abstract

“…A common feature shared by species that exhibit a relatively low rate of cancer incidence is comparatively low mass-specific metabolic rates. Altered cellular metabolism, particularly in response to glucose dysregulation and obesity, has been strongly implicated in multiple human cancers [ 87 ]. Indeed, an altered cancer risk in immigrants taking on a Westernized lifestyle has been appreciated [ 88 ].…”

Section: Extremophiles Aging and Peto's Paradoxmentioning

confidence: 99%

Questioning the preclinical paradigm: natural, extreme biology as an alternative discovery platform

Buffenstein

Nelson

Corbit

2014

Aging

View full text Add to dashboard Cite

The pace at which science continues to advance is astonishing. From cosmology, microprocessors, structural engineering, and DNA sequencing our lives are continually affected by science-based technology. However, progress in treating human ailments, especially age-related conditions such as cancer and Alzheimer's disease, moves at a relative snail's pace. Given that the amount of investment is not disproportionately low, one has to question why our hopes for the development of efficacious drugs for such grievous illnesses have been frustratingly unrealized. Here we discuss one aspect of drug development –rodent models – and propose an alternative approach to discovery research rooted in evolutionary experimentation. Our goal is to accelerate the conversation around how we can move towards more translative preclinical work.

show abstract

“…Several epidemiological studies have consistently shown an inverse association between consumption of vegetables and fruits and the risk of human cancers at many sites. Wickia & Hagmannc (2011) recently reported that many case-control and cohort studies are dealing with the effect of fruits and vegetables on cancer incidence [25]. Early data indicated a beneficial effect [26] and, as recently as 2008, Freedman et al found a reduced occurrence of head and neck cancers with increased fruit and vegetable consumption [27].…”

Section: Nutrition and Colon Cancermentioning

confidence: 99%