Die Rolle der Augenheilkunde in der COVID-19-Pandemie

Rokohl, Alexander C.; Loreck, Niklas; Matos, Philomena A Wawer; Mor, Joel M.; Zwingelberg, Sarah Barbara; Grajewski, Rafael S.; Cursiefen, Claus; Heindl, Ludwig M.

doi:10.1007/s00347-020-01148-9

Cited by 8 publications

(43 citation statements)

References 26 publications

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Section: Introductionmentioning

confidence: 99%

“…The coronavirus disease 19 (COVID-19) pandemic, caused by the severe acute respiratory syndrome-related coronavirus (SARS-CoV-2), is a public health emergency of tremendous international relevance [1][2][3][4][5][6]. SARS-CoV-2 spreads via human-to-human and seems to be transmitted mainly through respiratory droplets and contact with infected persons, less commonly via smear infection [1,2,4,5]. Furthermore, there seems to be a significant risk for ophthalmologists and medical staff to be infected with SARS-CoV-2 during the ophthalmological examination, treatment, or care due to the close proximity to infected (but often still asymptomatic) patients or colleagues [1,2,4,[7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…SARS-CoV-2 spreads via human-to-human and seems to be transmitted mainly through respiratory droplets and contact with infected persons, less commonly via smear infection [1,2,4,5]. Furthermore, there seems to be a significant risk for ophthalmologists and medical staff to be infected with SARS-CoV-2 during the ophthalmological examination, treatment, or care due to the close proximity to infected (but often still asymptomatic) patients or colleagues [1,2,4,[7][8][9]. In addition, this potentially high risk seems to affect the mental health of ophthalmologists and the medical staff resulting in anxiety and depression symptoms [10].…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies reported the presence of the entrance receptor of SARS-CoV-2, the angiotensin-converting enzyme 2 (ACE 2), on the ocular surface and that a significant proportion of SARS-COV-2-positive patients demonstrates unspecific conjunctivitis [1,6,[11][12][13]. Furthermore, SARS-CoV-2 was detected in ocular tissues, in tears, and in conjunctival secretions of COVID-19 patients [3,4,6,11,[14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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No secret hiding place? Absence of SARS-CoV-2 on the ocular surface of 1145 hospitalized patients in a pandemic area

Rokohl

Grajewski

Matos

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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Objectives The aims of this study were to evaluate the isolated prevalence of real-time reverse transcriptase-polymerase chain reaction (RT-PCR)–confirmed SARS-CoV-2 on the ocular surface without systemic infection in hospitalized asymptomatic patients and to determine the risk for ophthalmologists and medical staff to be infected by prescreened asymptomatic patients in a tertiary eye care center. Methods In this prospective, observational study, bilateral swaps of the conjunctiva in the lower fornices as well as nasopharyngeal swaps were collected in 1145 hospitalized asymptomatic patients of a tertiary eye care center. Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) analysis was performed for each swap to evaluate the prevalence of SARS-CoV-2. Demographic data and potential risk factors for an isolated infection of the ocular surface were noted. Results Two thousand two hundred eighty-eight (99.9%) of all 2290 tested eyes had negative results in the RT-PCR analysis of the conjunctival swabs. One patient had bilateral false-positive results in the conjunctival swabs. None of the 1145 patients had any positive RT-PCR-confirmed result in the nasopharyngeal swabs. Conclusions The risk for an isolated conjunctival viral activity in patients with a negative nasopharyngeal swab-based RT-PCR seems to be absent or extremely low, suggesting no need to perform additional conjunctival swabs in patients with negative nasopharyngeal swabs. Furthermore, the risk of a work-related SARS-CoV-2 infection due to direct contact with preselected asymptomatic patients in an eye care center is very low, especially when additional hygiene standards and safe distances are respected carefully. This might reassure medical staff and reduce the fear of SARS-CoV-2 infection.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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No secret hiding place? Absence of SARS-CoV-2 on the ocular surface of 1145 hospitalized patients in a pandemic area

Rokohl

Grajewski

Matos

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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“…This is an important issue as cancer tissue has been shown to have an impact on expression levels of these entry molecules for SARS-CoV-2 ( Kong et al, 2020 ), while conjunctivitis has been reported as an ocular manifestation of coronavirus disease 2019 (COVID-19)( Xia et al, 2020 ). Furthermore, ophthalmologists and eye-care personnel have been described at risk for transmission of COVID-19 due to close contact to patients during examination ( Rokohl et al, 2020 ).…”

mentioning

confidence: 99%

Malignancy going viral: ACE2 and TMPRSS2 expression in conjunctival neoplastic diseases

Grajewski

Rokohl

Becker

et al. 2021

Annals of Anatomy - Anatomischer Anzeiger

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Epidemiologische Auswirkungen der COVID-19-Pandemie auf Enukleationsfälle in Deutschland

2023

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Zusammenfassung Fragestellung Bestimmung der Enukleationsrate sowie der Auswirkungen der COVID-19-Pandemie auf diese in Deutschland. Methodik Für die Bestimmung der Enukleationsraten der Jahre 2019 und 2020 in Deutschland erfolgten der Export der Prozedurenschlüssel 5‑163.0 bis 5‑163.23 und 5‑163.x aus dem Diagnosis Related Group(DRG)-Register und die statistische Auswertung dieser Daten. Ergebnisse Die Zahl der Enukleationen verringerte sich 2020 um 16,6 % im Vergleich zu 2019 von 1295 auf 1080 Fälle (p = 0,17); 54,1 % der Patienten waren männlich. Im Jahr 2019 waren 53 % der Patienten zum Zeitpunkt der Enukleation älter als 65 Jahre, im Jahr 2020 56 % der Fälle. Die häufigste Indikation zur Enukleation war in beiden Jahren Phthisis bulbi (n = 373 bzw. n = 307) mit 29,7 % der Fälle, gefolgt von Malignomen der Aderhaut (24 %). Die Enukleation mit gleichzeitigem Einbringen eines alloplastischen Augenhöhlenimplantats in die Tenonkapsel stellte das häufigste Verfahren dar (38,7 % kombinierter 2‑Jahres-Durchschnitt), gefolgt von einer umhüllten Variante (26,6 %) und einem bulbären Implantat aus nichtresorbierbaren mikroporösen Materialien (16,8 %), ohne signifikante Veränderung zwischen den Jahren. Enukleationen ohne Einbringen eines Implantats stiegen von 7,8 % im Jahr 2019 auf 11,1 % im Jahr 2020 (p = 0,006). Der Anteil der Patienten, die sich einer Reoperation unterziehen mussten, stieg leicht von 5,6 auf 8 % (p = 0,018). Die meisten Eingriffe (65,6 %) wurden in großen öffentlichen Krankenhäusern (≥ 1000 Betten) durchgeführt. Schlussfolgerungen Trotz des Rückgangs der Gesamtzahl der durchgeführten Eingriffe wurde die Enukleationsrate in Deutschland durch die COVID-19-Pandemie nicht signifikant verändert. Die Enukleationsrate ohne Implantate und Reoperationen nahm signifikant zu.

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Die Rolle der Augenheilkunde in der COVID-19-Pandemie

Cited by 8 publications

References 26 publications

No secret hiding place? Absence of SARS-CoV-2 on the ocular surface of 1145 hospitalized patients in a pandemic area

No secret hiding place? Absence of SARS-CoV-2 on the ocular surface of 1145 hospitalized patients in a pandemic area

Malignancy going viral: ACE2 and TMPRSS2 expression in conjunctival neoplastic diseases

Epidemiologische Auswirkungen der COVID-19-Pandemie auf Enukleationsfälle in Deutschland

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