Die Cardenolide von <i>Parquetina nigrescens</i> (A<scp>FZEL</scp>.) B<scp>ULLOCK</scp>. Glykoside und Aglykone, 270. Mitteilung [1]

Berthold, R.; Wehrli, W.; Reichstein, T.

doi:10.1002/hlca.19650480725

Cited by 19 publications

(3 citation statements)

References 43 publications

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“…Strophanthidin.-A portion (27 mg) of fraction 12 was recrystallized from CHC13 to afford colorless crystals of strophanthidin, mp 138-l4l°/222-228°[lit. (25) 128-l42°/228-24l°], Ir and 'H-nmr spectra were identical to those of an authentic sample. Tic on silica gel with CHCl3-Me0H-H20 (70:26:4) EtOAc-cyclohexane (1:1), and MeOH-CHCl3 (15:75) and on alumina with MeOH-CHCl3 (15:75) and CHCl3-Me0H-H20 (70:26:4) gave Rf values identical with those of an authentic sample.…”

Section: Methodsmentioning

confidence: 56%

Constituents of Erysimum inconspicuum. Two Sulfur-Containing Lactone Compounds

Piatak¹,

Tang²,

Sørensen³

1985

J. Nat. Prod.

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The alcohol extract of Erysimum inconspicuum fruits, which exhibited cytotoxic activity against the KB cell line and some activity against the P-388 lymphocytic leukemia in vivo, was studied. Strophanthidin, uzarigenin, and two sulfur-containing lactones, erysulfone[6-methylsulfonyl-4-hydroxyhexanoic acid lactone] and erysulfoxide[6-methylsulfinyl-4-hydroxyhexanoic acid lactone], were isolated and characterized by spectral data.

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Section: Methodsmentioning

confidence: 56%

Constituents of Erysimum inconspicuum. Two Sulfur-Containing Lactone Compounds

Piatak¹,

Tang²,

Sørensen³

1985

J. Nat. Prod.

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“…In 1954, the chemical investigation of P. nigrescens resulted in strophanthidin ( 28 ) and strophanthidol ( 29 ), with both containing an oxygenic substituent at C-19 [24]. Later, in 1957 and 1965, eight analogues ( 30 – 37 ) were isolated from the same species [25,26]. Compounds 35 – 37 are reduced by a pair of hydrogen atoms to form a double bond at C-16 and C-17 compared with 28 and 29 .…”

Section: Chemical Constituents From the Genus Periplocamentioning

confidence: 99%

Genus Periploca (Apocynaceae): A Review of Its Classification, Phytochemistry, Biological Activities and Toxicology

et al. 2019

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The genus Periploca belongs to the family Apocynaceae, which is composed of approximately ten species of plants according to incomplete statistics. Most of these plants serve as folk medicines with a long history, especially Periploca sepium and Periploca forrestii. The botanical classifications, chemical constituents, biological activities and toxicities of the genus Periploca were summarized in the literature from 1897 to early 2019. Though the botanical classification of this genus is controversial, these species are well-known to be rich sources of diverse and complex natural products—above all, cardiac steroids and C21 pregnane steroids with special structures and obvious pharmacological activities. The various crude extracts and 314 isolated metabolites from this genus have attracted much attention in intensive biological studies, indicating that they are equipped with cardiotonic, anti-inflammatory, immunosuppressive, antitumor, antimicrobial, antioxidant, insecticidal and other properties. It is noteworthy that some cardiac glycosides showed hepatotoxicity and cardiotoxicity at certain doses. Therefore, in view of the medical and agricultural value of the genus Periploca, in-depth investigations of the pharmacology in vivo, the mechanisms of biological actions, and the pharmacokinetics of the active ingredients should be carried out in the future. Moreover, in order to ensure the safety of clinical medication, the potential toxicities of cardiac glycosides or other compounds should also be paid attention. This systematic review provides an important reference base for applied research on pharmaceuticals and pesticides from this genus.

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“…The leaves of P. nigrescens Afzel, (Periplocaceae) have been extensively used in traditional medicine as an antiinfective agent in East and West Africa (1). Previous work on P. nigrescens has resulted in the isolation of cardiac glycosides of the strophanthidin type from the stem and seeds (2,3), cymarin, monohydroxyolean-12-enecarboxylic acid, and a mixtrue of ci-and 3-amyrin from the roots (4), and calocin, genin, and plocigenin from the dried twigs (5).…”

Section: Acknowledgementsmentioning

confidence: 99%