Dictyoceratin-A and -B, Novel Antimicrobial Terpenoids from the Okinawan Marine Sponge sp.

Nakamura, Hideshi; Songzhi, Deng; Kobayashi, Jun’ichi; Ohizumi, Yasushi; Hiratå, Yoshimasa

doi:10.1016/s0040-4020(01)87643-2

Cited by 49 publications

(54 citation statements)

References 6 publications

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“…All thorectandrols, including the parent compound of the group palauolide [21] and palauolol [22] have been assayed for antiproliferative activity against human tumor cell lines and found to be active against all but one of the cell lines assayed [23] . Sponges of the genus Hippospongia are a source of various sesterterpenoids, which possess a broad spectrum of bioactivities, including isocitrate lyase (ICL) inhibitory [24] , cytotoxic [25][26][27][28][29][30] , antispasmodic [31] , and antibacterial [32] activities. Recently Chang et al, 2012 [32] isolated two novel sesterterpenoids from Hippospongia sp.…”

Section: Sesterterpenoids (C 25 )mentioning

confidence: 99%

Novel natural product discovery from obligate symbiotic organisms of marine sponges

Monaco

Quinlan

2018

J Nat Agents Mol Ther

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A rich source for the discovery of novel, pharmacologically active natural products have been the terrestrial plants and microbes, accounting for about 85% of the approved natural products in pharmaceutical use, and about 60% of approved pharmaceuticals and new drug applications submission annually. Discovery in the marine environment has lagged due to the difficulty of exploration in this ecological niche. Such exploration began in the 1950's, after technological advances such as scuba diving which allowed collection of marine organisms, primarily to a depth of about 15 m, which was the limit of that technology. Natural products from filter feeding marine invertebrates and in particular, sponges, have proven to be a rich source of structurally unique pharmacologically active compounds, with over 16,000 molecules isolated thus far and a continuing pace of discovery at hundreds of novel bioactive molecules per year. All classes of pharmaceuticals have been represented in this discovery process, including antiprotozoals, pesticides, TGF-beta inhibitors, cationic channel blockers, anticancer, cytotoxic, antiviral, anti-inflammatory and antibacterial compounds. Important biosynthetic pathways found in sponges which give rise to these compounds include the terpenoid, fatty acid, polyketoid, quinone reductase, alkaloid, isoprenoid, and non-ribosomal protein synthase pathways as summarized in this article.

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Section: Sesterterpenoids (C 25 )mentioning

confidence: 99%

Novel natural product discovery from obligate symbiotic organisms of marine sponges

Monaco

Quinlan

2018

J Nat Agents Mol Ther

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“…Sponges of the genus Hippospongia are a source of various sesterterpenoids, which possess a broad spectrum of bioactivities, including isocitrate lyase (ICL) inhibitory [29], cytotoxic [30][31][32][33][34][35], antispasmodic [36], and antibacterial [37] activities. Recently Chang et al, (2012) isolated two novel sesterterpenoids from Hippospongia sp.…”

Section: Sesterterpenoids (C 25 )mentioning

confidence: 99%

Novel Natural Product Discovery from Marine Sponges and their Obligate Symbiotic Organisms

Monaco

Quinlan

2014

Preprint

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Discovery of novel natural products is an accepted method for the elucidation of pharmacologically active molecules and drug leads. Best known sources for such discovery have been terrestrial plants and microbes, accounting for about 85% of the approved natural products in pharmaceutical use (1), and about 60% of approved pharmaceuticals and new drug applications annually (2). Discovery in the marine environment has lagged due to the difficulty of exploration in this ecological niche. Exploration began in earnest in the 1950's, after technological advances such as scuba diving allowed collection of marine organisms, primarily at a depth to about 15m. Natural products from filter feeding marine invertebrates and in particular, sponges, have proven to be a rich source of structurally unique pharmacologically active compounds, with over 16,000 molecules isolated thus far (3, 1) and a continuing pace of discovery at hundreds of novel bioactive molecules per year. All classes of pharmaceuticals have been represented in this discovery process, including antiprotazoals, pesticides, TGF-beta inhibitors, cationic channel blockers, anticancer, cytotoxic, antiviral, anti-inflammatory and antibacterial compounds. Important biosynthetic pathways found in sponges which give rise to these compounds include the terpenoid (4), fatty acid, polyketoid, quinone reductase, alkaloid, isoprenoid (5), and non-ribosomal protein synthase pathways.

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“…Hippospongia metachromia), dictoceratidin A 99, which had previously been isolated from a Hippospongia sp. 74 and five new compounds, dactylospongenones A-D 100-103 and dictoceratidin C 104. 75 No bioactivity was recorded for the new compounds although the crude extract of the sponge was antimicrobial, probably due to the presence of ilimaquinone.…”

Section: Dactylospongia Spmentioning

confidence: 99%

Investigations of the Marine Flora and Fauna of the Islands of Palau

Faulkner¹,

Newman²,

Cragg³

2004

ChemInform

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Dictyoceratin-A and -B, Novel Antimicrobial Terpenoids from the Okinawan Marine Sponge sp.

Cited by 49 publications

References 6 publications

Novel natural product discovery from obligate symbiotic organisms of marine sponges

Novel natural product discovery from obligate symbiotic organisms of marine sponges

Novel Natural Product Discovery from Marine Sponges and their Obligate Symbiotic Organisms

Investigations of the Marine Flora and Fauna of the Islands of Palau

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