Dichelobacter nodosus, Fusobacterium necrophorum and the epidemiology of footrot

Bennett, Grant; Hickford, Jonathan G. H.; Sedcole, Richard; Zhou, Huitong

doi:10.1016/j.anaerobe.2009.02.002

Cited by 67 publications

(50 citation statements)

References 18 publications

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“…These regions are key sites for both early and advanced infectious hoof disease lesions as described in many species of domestic and nondomestic ruminants (Wani and Samanta 2005;Belloy et al 2007;Bennett et al 2009;Evans et al 2009). Though soft tissue lesions were not consistently detected, the five study elk had chronic disease, and earlier lesions may have been no longer apparent.…”

Section: Discussionmentioning

confidence: 99%

SEVERE HOOF DISEASE IN FREE-RANGING ROOSEVELT ELK (CERVUS ELAPHUS ROOSEVELTI) IN SOUTHWESTERN WASHINGTON, USA

Han

Mansfield

2014

Journal of Wildlife Diseases

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Section: Discussionmentioning

confidence: 99%

SEVERE HOOF DISEASE IN FREE-RANGING ROOSEVELT ELK (CERVUS ELAPHUS ROOSEVELTI) IN SOUTHWESTERN WASHINGTON, USA

Han

Mansfield

2014

Journal of Wildlife Diseases

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“…Fusobacterium necrophorum is a Gram-negative, non-spore-forming anaerobe. It has been strongly associated with ID and VFR Bennett et al, 2009). In a recent analysis from a longitudinal study (Witcomb et al, submitted), F. necrophorum was monitored in H, ID and VFR sheep and there was no difference in F. necrophorum load between feet with H, ID or VFR (except in some of the sheep with VFR).…”

Section: Comparison Of the Microbial Communities And Taxonomic Classimentioning

confidence: 99%

Ovine pedomics: the first study of the ovine foot 16S rRNA-based microbiome

et al. 2011

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We report the first study of the bacterial microbiome of ovine interdigital skin based on 16S rRNA by pyrosequencing and conventional cloning with Sanger-sequencing. Three flocks were selected, one a flock with no signs of footrot or interdigital dermatitis, a second flock with interdigital dermatitis alone and a third flock with both interdigital dermatitis and footrot. The sheep were classified as having either healthy interdigital skin (H) and interdigital dermatitis (ID) or virulent footrot (VFR). The ovine interdigital skin bacterial community varied significantly by flock and clinical condition. The diversity and richness of operational taxonomic units was greater in tissue from sheep with ID than H or VFR-affected sheep. Actinobacteria, Bacteriodetes, Firmicutes and Proteobacteria were the most abundant phyla comprising 25 genera. Peptostreptococcus, Corynebacterium and Staphylococcus were associated with H, ID and VFR, respectively. Sequences of Dichelobacter nodosus, the causal agent of ovine footrot, were not amplified because of mismatches in the 16S rRNA universal forward primer (27F). A specific real-time PCR assay was used to demonstrate the presence of D. nodosus, which was detected in all samples including the flock with no signs of ID or VFR. Sheep with ID had significantly higher numbers of D. nodosus (10 4 -10 9 cells per g tissue) than those with H or VFR feet.

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“…All lesion and healthy tissue biopsy samples were subjected to a species-specific F. necrophorum PCR assay as described originally (49). The primers used in this assay (Table 1) target the lktA gene which appears to be unique to F. necrophorum as it is not present in other Fusobacterium species (50).…”

Section: Genus-and Phylogroup-specific Treponeme Pcr Assaysmentioning

confidence: 99%

High-Level Association of Bovine Digital Dermatitis Treponema spp. with Contagious Ovine Digital Dermatitis Lesions and Presence of Fusobacterium necrophorum and Dichelobacter nodosus

Sullivan¹,

Clegg²,

Angell

et al. 2015

J Clin Microbiol

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Digital dermatitis (DD) is an infectious lameness commonly found in dairy cattle worldwide, and it is known as bovine digital dermatitis (BDD) or papillomatous digital dermatitis (PDD). The disease was first reported in 1980 in the United States (1) and in the late 1980s in the United Kingdom (2). BDD has also been confirmed in beef cattle (3, 4), and over the last 30 years, the disease has been recognized as an important cause of bovine lameness (5).Lameness in cattle and sheep has serious animal welfare and economic implications (6-9). The effects of lameness in cattle include a decrease in milk yield (9, 10) and fertility (8, 11-13) and an increase in rate of culling (12,14). This has been found to be particularly true for cattle suffering from BDD (8, 15, 16) with a recent study of the cost of lameness in the United States estimating that on average, BDD costs $133 per case (17).BDD is now a worldwide problem, and controlling BDD on dairy operations has proven difficult. Moreover, in the last 20 years, sheep in the United Kingdom have been identified with a form of DD termed contagious ovine digital dermatitis (CODD), which is rapidly emerging as a severe infectious foot disease since it was first reported in the United Kingdom in 1997 (18-20). Now, CODD has spread into the Republic of Ireland (20), and it was recently reported in dairy goats in the United Kingdom (21), indicating further cross-species transmission. The contagious nature of DD is also evident by the reports of a manifestation of the disease in a wildlife host, North American elk (Cervus elaphus) from Washington State (22). The reports of DD in previously unaffected species, including U.S. wildlife, suggests a much greater global threat of the disease than previously considered.BDD in cattle manifests in several forms, but most frequently as an ulcerative lesion of the digital skin located immediately above the coronary band between the heel bulbs which results in severe lameness (23). The clinical features of CODD in sheep are slightly different, mainly because the initial lesion site on the sheep foot is different. CODD lesions commence at the coronary band and then run under the hoof horn capsule dorsally and abaxially (24). CODD frequently presents a particularly severe outcome where the whole horn capsule can be lost (18,(25)(26)(27). As a result of the severity of the lesions, sheep can be extremely lame, impacting the welfare of the affected sheep (28). This is concurrent with the lesion pathology identified in elk, described as erosive lesions on

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Dichelobacter nodosus, Fusobacterium necrophorum and the epidemiology of footrot

Cited by 67 publications

References 18 publications

SEVERE HOOF DISEASE IN FREE-RANGING ROOSEVELT ELK (CERVUS ELAPHUS ROOSEVELTI) IN SOUTHWESTERN WASHINGTON, USA

SEVERE HOOF DISEASE IN FREE-RANGING ROOSEVELT ELK (CERVUS ELAPHUS ROOSEVELTI) IN SOUTHWESTERN WASHINGTON, USA

Ovine pedomics: the first study of the ovine foot 16S rRNA-based microbiome

High-Level Association of Bovine Digital Dermatitis Treponema spp. with Contagious Ovine Digital Dermatitis Lesions and Presence of Fusobacterium necrophorum and Dichelobacter nodosus

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