Dicamba-induced genotoxicity in Chinese hamster ovary (CHO) cells is prevented by vitamin E

González, Norma Viviana; Soloneski, Sonia; Larramendy, Marcelo L.

doi:10.1016/j.jhazmat.2008.06.097

Cited by 41 publications

(45 citation statements)

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“…Gonzàlez et al (2011) found that dicamba and one of its commercial formulation banvel induced a significant increase in MN and NBUD formation at a concentration range of 50-500 lg/mL in Chinese hamster ovary cells. The damaging activity of dicamba in different mammalian cell targets was also previously observed by the same research group (Gonzàlez et al 2006(Gonzàlez et al , 2007(Gonzàlez et al , 2009). The results of these studies and some others (Amer and Aly 2001;Cenkci et al 2010) are in agreement with the results of our study, although different cell types and/or test system were used.…”

Section: Discussionsupporting

confidence: 73%

“…Unfortunately, to our best knowledge, there is no study available on the genotoxic and/ or cytotoxic effects of NAAm on humans in the literature. However, some synthetic auxins, such as 2,4-dichlorophenoxyacetic acid (2,4-D) (Holland et al 2002;Cenkci et al 2010), dicamba (Gonzàlez et al 2007(Gonzàlez et al , 2009Gonzàlez et al 2011), and synthetic IAA (Salopek-Sondi et al 2010) have been found genotoxic, mutagenic and cytotoxic in various test systems. Thus, taking into account these facts, it has become important to evaluate the possible genotoxic potential of NAAm on humans.…”

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confidence: 99%

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In vitro genotoxicity assessment of the synthetic plant growth regulator, 1-naphthaleneacetamide

Kocaman

Güven

2015

Cytotechnology

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1-Naphthaleneacetamide (NAAm) is a synthetic plant growth regulator in the auxin family that is widely used in agriculture to promote the growth of numerous fruits, for root cuttings and as a fruit thinning agent. The potential genotoxic effects of NAAm were investigated in vitro by the chromosome aberrations (CAs), and cytokinesis-block micronucleus assays in human peripheral blood lymphocytes (PBLs) for the first time. The human PBLs were treated with 20, 40, 80, and 160 lg/mL of NAAm for 24 and 48 h. The results of this study showed that NAAm significantly induced the formation of structural CA and MN for all concentrations (20, 40, 80 and 160 lg/mL) and treatment periods (24 and 48 h) when compared with the negative and the solvent control. In addition, the higher concentrations of NAAm (80 and 160 lg/mL) caused a statistically significant increase in nuclear bud (NBUD) formation for both 24 and 48 h treatment times. With regard to the cell cycle kinetics, at all the tested concentrations, NAAm caused a statistically significant reduction in the mitotic index (MI) only for 48 h treatment period and also in the nuclear division index (NDI) for both 24 and 48 h treatment periods as compared to the control groups. The reductions in the MI and NDI occured in a concentration-dependent manner for both treatment times. In conclusion, the present results indicate that in the tested experimental conditions, NAAm was genotoxic and cytotoxic on human PBLs in vitro.

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Section: Discussionsupporting

confidence: 73%

mentioning

confidence: 99%

In vitro genotoxicity assessment of the synthetic plant growth regulator, 1-naphthaleneacetamide

Kocaman

Güven

2015

Cytotechnology

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“…Similar observations were reported by Sorensen et al (2004Sorensen et al ( , 2005 on Dicamba-treated CHO cells cultured in the presence of reduced-clay smectites but not when the clay system was not included within the culture protocol. Both González et al (2006González et al ( , 2007González et al ( , 2009) and Perocco et al (1990) demonstrated the ability of the herbicide to induce SCEs in CHO cells and human lymphocytes with and without S9 fraction treated in vitro, respectively. The induction of alterations in the cell-cycle progression of different cellular systems including CHO cells and human lymphocytes were reported to occur after in vitro exposure to Dicamba (González et al, 2006(González et al, , 2009).…”

Section: Genotoxicity and Cytotoxicity Of Dicambamentioning

confidence: 99%

“…Both González et al (2006González et al ( , 2007González et al ( , 2009) and Perocco et al (1990) demonstrated the ability of the herbicide to induce SCEs in CHO cells and human lymphocytes with and without S9 fraction treated in vitro, respectively. The induction of alterations in the cell-cycle progression of different cellular systems including CHO cells and human lymphocytes were reported to occur after in vitro exposure to Dicamba (González et al, 2006(González et al, , 2009). Finally, similar results were reported for the cell viability assay in CHO cells (Sorensen et al, 2004;González et al, 2009).…”

Section: Genotoxicity and Cytotoxicity Of Dicambamentioning

confidence: 99%

“…The induction of alterations in the cell-cycle progression of different cellular systems including CHO cells and human lymphocytes were reported to occur after in vitro exposure to Dicamba (González et al, 2006(González et al, , 2009). Finally, similar results were reported for the cell viability assay in CHO cells (Sorensen et al, 2004;González et al, 2009). In genotoxic and cytotoxic studies in vivo, Dicamba was able to induce different types of lesions.…”

Section: Genotoxicity and Cytotoxicity Of Dicambamentioning

confidence: 99%

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Herbicides in Argentina. Comparative Evaluation of the Genotoxic and Cytotoxic Effects on Mammalian Cells Exerted by Auxinic Members

Soloneski¹,

Larramendy²

2011

Herbicides and Environment

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The Need for a Closer Look at Pesticide Toxicity during GMO Assessment

Mesnage

Séralini

2014

Practical Food Safety

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Public policy is regularly shaken by health crises or unexpected discoveries; future directions in toxicology assessment are therefore urgently needed. This chapter focuses on agricultural genetically modified organisms (GMOs) because they are essentially pesticide-plants, designed to tolerate and/or produce new pesticide residues in food and feed. Moreover, the usual concepts of regulatory toxicology become erroneous or insufficient with regards to endocrine or nervous disruption, or epigenetic effects. Most pollutants affect cell-cell communication systems in the same way as unsolicited spam emails, and may promote chronic and environmental pathologies. We also describe how formulated pes ticides are mixtures which have not been investigated for their long-term toxicities. They contain adjuvants that are even more toxic than the sup posedly active principle. Finally, long-term and multigenerational testing in vivo often appears essential. This can be accomplished within two years on rats, independently of the biotechnology industry, with raw data being transparent to the scientific community to allow healthy debate before the next health crisis.

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Dicamba-induced genotoxicity in Chinese hamster ovary (CHO) cells is prevented by vitamin E

Cited by 41 publications

References 46 publications

In vitro genotoxicity assessment of the synthetic plant growth regulator, 1-naphthaleneacetamide

In vitro genotoxicity assessment of the synthetic plant growth regulator, 1-naphthaleneacetamide

Herbicides in Argentina. Comparative Evaluation of the Genotoxic and Cytotoxic Effects on Mammalian Cells Exerted by Auxinic Members

The Need for a Closer Look at Pesticide Toxicity during GMO Assessment

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